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Comparisons of serum vitamin D levels, status, and determinants in populations with and without chronic kidney disease not requiring renal dialysis: a 24-hour urine collection population-based study.
J Ren Nutr. 2014 Sep; 24(5):303-12.JR

Abstract

OBJECTIVE

Vitamin D deficiency is frequent in the general population and might be even more prevalent among populations with kidney failure. We compared serum vitamin D levels, vitamin D insufficiency/deficiency status, and vitamin D level determinants in populations without chronic kidney disease (CKD) and with CKD not requiring renal dialysis.

DESIGN AND METHODS

This was a cross-sectional, multicenter, population-based study conducted from 2010 to 2011. Participants were from 10 centers that represent the geographical and cultural diversity of the Swiss adult population (≥15 years old).

INTERVENTION

CKD was defined using estimated glomerular filtration rate and 24-hour albuminuria. Serum vitamin D was measured by liquid chromatography-tandem mass spectrometry. Statistical procedures adapted for survey data were used.

MAIN OUTCOME MEASURE

We compared 25-hydroxy-vitamin D (25(OH)D) levels and the prevalence of vitamin D insufficiency/deficiency (serum 25(OH)D < 30 ng/mL) in participants with and without CKD. We tested the interaction of CKD status with 6 a priori defined attributes (age, sex, body mass index, walking activity, serum albumin-corrected calcium, and altitude) on serum vitamin D level or insufficiency/deficiency status taking into account potential confounders.

RESULTS

Overall, 11.8% (135 of 1,145) participants had CKD. The 25(OH)D adjusted means (95% confidence interval [CI]) were 23.1 (22.6-23.7) and 23.5 (21.7-25.3) ng/mL in participants without and with CKD, respectively (P = .70). Vitamin D insufficiency or deficiency was frequent among participants without and with CKD (75.3% [95% CI 69.3-81.5] and 69.1 [95% CI 53.9-86.1], P = .054). CKD status did not interact with major determinants of vitamin D, including age, sex, BMI, walking minutes, serum albumin-corrected calcium, or altitude for its effect on vitamin D status or levels.

CONCLUSION

Vitamin D concentration and insufficiency/deficiency status are similar in people with or without CKD not requiring renal dialysis.

Authors+Show Affiliations

Unit of Population Epidemiology, Division of Primary Care, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland; Community Prevention Unit, University Institute of Social and Preventive Medicine, Lausanne, Switzerland; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia. Electronic address: idris.guessous@hcuge.ch.Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.Food Safety and Veterinary Office, Bern, Switzerland.Unit of Population Epidemiology, Division of Primary Care, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.Community Prevention Unit, University Institute of Social and Preventive Medicine, Lausanne, Switzerland.Service of Nephrology and Hypertension, Lausanne University Hospitals, Lausanne, Switzerland.Community Prevention Unit, University Institute of Social and Preventive Medicine, Lausanne, Switzerland.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25030223

Citation

Guessous, Idris, et al. "Comparisons of Serum Vitamin D Levels, Status, and Determinants in Populations With and Without Chronic Kidney Disease Not Requiring Renal Dialysis: a 24-hour Urine Collection Population-based Study." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 24, no. 5, 2014, pp. 303-12.
Guessous I, McClellan W, Kleinbaum D, et al. Comparisons of serum vitamin D levels, status, and determinants in populations with and without chronic kidney disease not requiring renal dialysis: a 24-hour urine collection population-based study. J Ren Nutr. 2014;24(5):303-12.
Guessous, I., McClellan, W., Kleinbaum, D., Vaccarino, V., Zoller, O., Theler, J. M., Paccaud, F., Burnier, M., & Bochud, M. (2014). Comparisons of serum vitamin D levels, status, and determinants in populations with and without chronic kidney disease not requiring renal dialysis: a 24-hour urine collection population-based study. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 24(5), 303-12. https://doi.org/10.1053/j.jrn.2014.04.005
Guessous I, et al. Comparisons of Serum Vitamin D Levels, Status, and Determinants in Populations With and Without Chronic Kidney Disease Not Requiring Renal Dialysis: a 24-hour Urine Collection Population-based Study. J Ren Nutr. 2014;24(5):303-12. PubMed PMID: 25030223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparisons of serum vitamin D levels, status, and determinants in populations with and without chronic kidney disease not requiring renal dialysis: a 24-hour urine collection population-based study. AU - Guessous,Idris, AU - McClellan,William, AU - Kleinbaum,David, AU - Vaccarino,Viola, AU - Zoller,Otmar, AU - Theler,Jean-Marc, AU - Paccaud,Fred, AU - Burnier,Michel, AU - Bochud,Murielle, AU - ,, Y1 - 2014/07/13/ PY - 2014/02/04/received PY - 2014/03/27/revised PY - 2014/04/08/accepted PY - 2014/7/18/entrez PY - 2014/7/18/pubmed PY - 2015/5/15/medline SP - 303 EP - 12 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 24 IS - 5 N2 - OBJECTIVE: Vitamin D deficiency is frequent in the general population and might be even more prevalent among populations with kidney failure. We compared serum vitamin D levels, vitamin D insufficiency/deficiency status, and vitamin D level determinants in populations without chronic kidney disease (CKD) and with CKD not requiring renal dialysis. DESIGN AND METHODS: This was a cross-sectional, multicenter, population-based study conducted from 2010 to 2011. Participants were from 10 centers that represent the geographical and cultural diversity of the Swiss adult population (≥15 years old). INTERVENTION: CKD was defined using estimated glomerular filtration rate and 24-hour albuminuria. Serum vitamin D was measured by liquid chromatography-tandem mass spectrometry. Statistical procedures adapted for survey data were used. MAIN OUTCOME MEASURE: We compared 25-hydroxy-vitamin D (25(OH)D) levels and the prevalence of vitamin D insufficiency/deficiency (serum 25(OH)D < 30 ng/mL) in participants with and without CKD. We tested the interaction of CKD status with 6 a priori defined attributes (age, sex, body mass index, walking activity, serum albumin-corrected calcium, and altitude) on serum vitamin D level or insufficiency/deficiency status taking into account potential confounders. RESULTS: Overall, 11.8% (135 of 1,145) participants had CKD. The 25(OH)D adjusted means (95% confidence interval [CI]) were 23.1 (22.6-23.7) and 23.5 (21.7-25.3) ng/mL in participants without and with CKD, respectively (P = .70). Vitamin D insufficiency or deficiency was frequent among participants without and with CKD (75.3% [95% CI 69.3-81.5] and 69.1 [95% CI 53.9-86.1], P = .054). CKD status did not interact with major determinants of vitamin D, including age, sex, BMI, walking minutes, serum albumin-corrected calcium, or altitude for its effect on vitamin D status or levels. CONCLUSION: Vitamin D concentration and insufficiency/deficiency status are similar in people with or without CKD not requiring renal dialysis. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/25030223/Comparisons_of_serum_vitamin_D_levels_status_and_determinants_in_populations_with_and_without_chronic_kidney_disease_not_requiring_renal_dialysis:_a_24_hour_urine_collection_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(14)00078-8 DB - PRIME DP - Unbound Medicine ER -