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Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)".
Int J Clin Exp Pathol. 2014; 7(6):3112-22.IJ

Abstract

Cholangiocarcinoma (CC) of the biliary tract occasionally presents a predominant intraductal papillary growth in the bile ducts, called as biliary tract carcinoma (BTC) of papillary growth (PG) and intrahepatic CC (ICC) of intraductal growth (IG) type. Recently, intraductal papillary neoplasm of bile duct (IPNB) has been proposed as a pre-invasive biliary neoplasm. This study was performed to characterize pathologically BTC of PG type and ICC of IG type with respect to IPNB. It was found that 126 of such 154 CCs (81.8%) fulfilled the criteria of IPNB, while the remaining 28 cases showed different histologies, such as tubular adenocarcinoma and carcinosarcoma. These IPNBs occurred in old aged patients with a male predominance, and the left lobe was rather frequently affected in the liver. A majority of these cases were high grade IPNB (43 cases) and invasive IPNB (77 cases), while low grade IPNB was rare (6 cases). Pancreatobiliary type was predominant (48 cases) followed by gastric (30 cases), intestinal (29 cases) and oncocytic (19 cases) types. Mucus hypersecretion was found in 45 cases, and this was frequent in IPNB at the intrahepatic large bile duct and hilar bile ducts but rare at the extrahepatic bile ducts. Interestingly, 36 cases of high grade and invasive IPNBs contained foci of moderately differentiated adenocacinoma within the intraductal papillary tumor. In conclusion, a majority of ICC of IG type and BTC of PG type could be regarded as a IPNB lineage, and clinically detectable IPNBs were already a malignant papillary lesion.

Authors+Show Affiliations

Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa ; Department of Pathology, Shizuoka Cancer Center Shizuoka.Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa.Department of Pathology, National Cancer Center Tokyo.Department of Pathology, National Cancer Center Tokyo.Department of Pathology, Kyushu University Graduate School of Medicine Fukuoka.Department of Gastrointestinal Surgery, Tokyo Women's College of Medicine Tokyo.Department of Gastrointestinal Surgery, Tokyo Women's College of Medicine Tokyo.Department of Pathology, Tokyo Women's College of Medicine Tokyo.Department of Hepatobiliary Pancreatic Surgery, Tohoku University Graduate School of Medicine Sendai.Department of Hepatobiliary Pancreatic Surgery, Tohoku University Graduate School of Medicine Sendai.Department of Hepatobiliary Pancreatic Surgery, Kanazawa University Graduate of Medicine Kagoshima, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25031730

Citation

Nakanuma, Yasuni, et al. "Clinicopathological Characterization of So-called "cholangiocarcinoma With Intraductal Papillary Growth" With Respect to "intraductal Papillary Neoplasm of Bile Duct (IPNB)"." International Journal of Clinical and Experimental Pathology, vol. 7, no. 6, 2014, pp. 3112-22.
Nakanuma Y, Sato Y, Ojima H, et al. Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)". Int J Clin Exp Pathol. 2014;7(6):3112-22.
Nakanuma, Y., Sato, Y., Ojima, H., Kanai, Y., Aishima, S., Yamamoto, M., Ariizumi, S., Furukawa, T., Hayashi, H., Unno, M., & Ohta, T. (2014). Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)". International Journal of Clinical and Experimental Pathology, 7(6), 3112-22.
Nakanuma Y, et al. Clinicopathological Characterization of So-called "cholangiocarcinoma With Intraductal Papillary Growth" With Respect to "intraductal Papillary Neoplasm of Bile Duct (IPNB)". Int J Clin Exp Pathol. 2014;7(6):3112-22. PubMed PMID: 25031730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)". AU - Nakanuma,Yasuni, AU - Sato,Yasunori, AU - Ojima,Hidenori, AU - Kanai,Yae, AU - Aishima,Shinichi, AU - Yamamoto,Masakazu, AU - Ariizumi,Shun-ichi, AU - Furukawa,Toru, AU - Hayashi,Hiroki, AU - Unno,Michiaki, AU - Ohta,Tetsuo, AU - ,, Y1 - 2014/05/15/ PY - 2014/04/11/received PY - 2014/05/26/accepted PY - 2014/7/18/entrez PY - 2014/7/18/pubmed PY - 2015/5/27/medline KW - Biliary tree KW - intraductal cholangiocarcinoma KW - intraductal papillary neoplasm KW - papillary cholangiocarcinoma KW - phenotype SP - 3112 EP - 22 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 7 IS - 6 N2 - Cholangiocarcinoma (CC) of the biliary tract occasionally presents a predominant intraductal papillary growth in the bile ducts, called as biliary tract carcinoma (BTC) of papillary growth (PG) and intrahepatic CC (ICC) of intraductal growth (IG) type. Recently, intraductal papillary neoplasm of bile duct (IPNB) has been proposed as a pre-invasive biliary neoplasm. This study was performed to characterize pathologically BTC of PG type and ICC of IG type with respect to IPNB. It was found that 126 of such 154 CCs (81.8%) fulfilled the criteria of IPNB, while the remaining 28 cases showed different histologies, such as tubular adenocarcinoma and carcinosarcoma. These IPNBs occurred in old aged patients with a male predominance, and the left lobe was rather frequently affected in the liver. A majority of these cases were high grade IPNB (43 cases) and invasive IPNB (77 cases), while low grade IPNB was rare (6 cases). Pancreatobiliary type was predominant (48 cases) followed by gastric (30 cases), intestinal (29 cases) and oncocytic (19 cases) types. Mucus hypersecretion was found in 45 cases, and this was frequent in IPNB at the intrahepatic large bile duct and hilar bile ducts but rare at the extrahepatic bile ducts. Interestingly, 36 cases of high grade and invasive IPNBs contained foci of moderately differentiated adenocacinoma within the intraductal papillary tumor. In conclusion, a majority of ICC of IG type and BTC of PG type could be regarded as a IPNB lineage, and clinically detectable IPNBs were already a malignant papillary lesion. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/25031730/Clinicopathological_characterization_of_so_called_"cholangiocarcinoma_with_intraductal_papillary_growth"_with_respect_to_"intraductal_papillary_neoplasm_of_bile_duct__IPNB_"_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25031730/ DB - PRIME DP - Unbound Medicine ER -