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Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.
PLoS One. 2014; 9(7):e101589.Plos

Abstract

The retrieval-extinction paradigm, which disrupts the reconsolidation of fear memories in humans, is a non-invasive technique that can be used to prevent the return of fear in humans. In the present study, unconditioned stimulus revaluation was applied in the retrieval-extinction paradigm to investigate its promotion of conditioned fear extinction in the memory reconsolidation window after participants acquired conditioned fear. This experiment comprised three stages (acquisition, unconditioned stimulus revaluation, retrieval-extinction) and three methods for indexing fear (unconditioned stimulus expectancy, skin conductance response, conditioned stimulus pleasure rating). After the acquisition phase, we decreased the intensity of the unconditioned stimulus in one group (devaluation) and maintained constant for the other group (control). The results indicated that both groups exhibited similar levels of unconditioned stimulus expectancy, but the devaluation group had significantly smaller skin conductance responses and exhibited a growth in conditioned stimulus + pleasure. Thus, our findings indicate unconditioned stimulus revaluation effectively promoted the extinction of conditioned fear within the memory reconsolidation window.

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Authors+Show Affiliations

Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Health Service Centers in Communities, South China Normal University, Guangzhou, China.

Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Health Service Centers in Communities, South China Normal University, Guangzhou, China.

Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Health Service Centers in Communities, South China Normal University, Guangzhou, China.

Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Health Service Centers in Communities, South China Normal University, Guangzhou, China.

Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Health Service Centers in Communities, South China Normal University, Guangzhou, China.

Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Health Service Centers in Communities, South China Normal University, Guangzhou, China.

MeSH

AdultConditioning, ClassicalEmotionsExtinction, PsychologicalFearFemaleGalvanic Skin ResponseHumansMaleMemory ConsolidationYoung Adult

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25033450

Citation

Zeng, Xiang-Xing, et al. "Unconditioned Stimulus Revaluation to Promote Conditioned Fear Extinction in the Memory Reconsolidation Window." PloS One, vol. 9, no. 7, 2014, pp. e101589.

Zeng XX, Du J, Zhuang CQ, et al. Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window. PLoS One. 2014;9(7):e101589.

Zeng, X. X., Du, J., Zhuang, C. Q., Zhang, J. H., Jia, Y. L., & Zheng, X. F. (2014). Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window. PloS One, 9(7), e101589. https://doi.org/10.1371/journal.pone.0101589

Zeng XX, et al. Unconditioned Stimulus Revaluation to Promote Conditioned Fear Extinction in the Memory Reconsolidation Window. PLoS One. 2014;9(7):e101589. PubMed PMID: 25033450.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window. AU - Zeng,Xiang-Xing, AU - Du,Juan, AU - Zhuang,Chu-Qun, AU - Zhang,Jun-Hua, AU - Jia,Yan-Lei, AU - Zheng,Xi-Fu, Y1 - 2014/07/17/ PY - 2014/04/03/received PY - 2014/05/23/accepted PY - 2014/7/18/entrez PY - 2014/7/18/pubmed PY - 2015/12/19/medline SP - e101589 EP - e101589 JF - PloS one JO - PLoS One VL - 9 IS - 7 N2 - The retrieval-extinction paradigm, which disrupts the reconsolidation of fear memories in humans, is a non-invasive technique that can be used to prevent the return of fear in humans. In the present study, unconditioned stimulus revaluation was applied in the retrieval-extinction paradigm to investigate its promotion of conditioned fear extinction in the memory reconsolidation window after participants acquired conditioned fear. This experiment comprised three stages (acquisition, unconditioned stimulus revaluation, retrieval-extinction) and three methods for indexing fear (unconditioned stimulus expectancy, skin conductance response, conditioned stimulus pleasure rating). After the acquisition phase, we decreased the intensity of the unconditioned stimulus in one group (devaluation) and maintained constant for the other group (control). The results indicated that both groups exhibited similar levels of unconditioned stimulus expectancy, but the devaluation group had significantly smaller skin conductance responses and exhibited a growth in conditioned stimulus + pleasure. Thus, our findings indicate unconditioned stimulus revaluation effectively promoted the extinction of conditioned fear within the memory reconsolidation window. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25033450/Unconditioned_stimulus_revaluation_to_promote_conditioned_fear_extinction_in_the_memory_reconsolidation_window_ DB - PRIME DP - Unbound Medicine ER -