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In vitro reactivities of blood lymphocytes from symptomatic and asymptomatic pigeon breeders to antigen and mitogens.
Int Arch Allergy Appl Immunol. 1989; 89(2-3):222-8.IA

Abstract

The proliferation of blood lymphocytes in response to pigeon gammaglobulin in the presence or absence of IL2 was measured in 9 symptomatic and 12 asymptomatic pigeon breeders and 24 controls. The symptomatic breeders exhibited spontaneous lymphocyte proliferation (p less than 0.001) when compared with controls whilst lymphocytes from asymptomatic breeders required the simultaneous addition of IL2 in order to proliferate (p less than 0.001). IL2 alone did not induce cellular proliferation. Both patient groups had abnormal T-cell functions and response to lectins and, in the symptomatic group, there existed an inverse correlation (r = -0.70, p less than 0.001) between specific antibody titres to pigeon gammaglobulin and the Con A response. We conclude that both patient groups have circulating, presensitized antigen-specific lymphocytes but these require different stimulatory signals at the cellular level.

Authors+Show Affiliations

Department of Medical Microbiology, Faculty of Medicine, University of Stellenbosch, Republic of South Africa.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2503454

Citation

Bouic, P J., et al. "In Vitro Reactivities of Blood Lymphocytes From Symptomatic and Asymptomatic Pigeon Breeders to Antigen and Mitogens." International Archives of Allergy and Applied Immunology, vol. 89, no. 2-3, 1989, pp. 222-8.
Bouic PJ, Nel NC, de Beer PM, et al. In vitro reactivities of blood lymphocytes from symptomatic and asymptomatic pigeon breeders to antigen and mitogens. Int Arch Allergy Appl Immunol. 1989;89(2-3):222-8.
Bouic, P. J., Nel, N. C., de Beer, P. M., & Joubert, J. R. (1989). In vitro reactivities of blood lymphocytes from symptomatic and asymptomatic pigeon breeders to antigen and mitogens. International Archives of Allergy and Applied Immunology, 89(2-3), 222-8.
Bouic PJ, et al. In Vitro Reactivities of Blood Lymphocytes From Symptomatic and Asymptomatic Pigeon Breeders to Antigen and Mitogens. Int Arch Allergy Appl Immunol. 1989;89(2-3):222-8. PubMed PMID: 2503454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro reactivities of blood lymphocytes from symptomatic and asymptomatic pigeon breeders to antigen and mitogens. AU - Bouic,P J, AU - Nel,N C, AU - de Beer,P M, AU - Joubert,J R, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 222 EP - 8 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 89 IS - 2-3 N2 - The proliferation of blood lymphocytes in response to pigeon gammaglobulin in the presence or absence of IL2 was measured in 9 symptomatic and 12 asymptomatic pigeon breeders and 24 controls. The symptomatic breeders exhibited spontaneous lymphocyte proliferation (p less than 0.001) when compared with controls whilst lymphocytes from asymptomatic breeders required the simultaneous addition of IL2 in order to proliferate (p less than 0.001). IL2 alone did not induce cellular proliferation. Both patient groups had abnormal T-cell functions and response to lectins and, in the symptomatic group, there existed an inverse correlation (r = -0.70, p less than 0.001) between specific antibody titres to pigeon gammaglobulin and the Con A response. We conclude that both patient groups have circulating, presensitized antigen-specific lymphocytes but these require different stimulatory signals at the cellular level. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/2503454/In_vitro_reactivities_of_blood_lymphocytes_from_symptomatic_and_asymptomatic_pigeon_breeders_to_antigen_and_mitogens_ DB - PRIME DP - Unbound Medicine ER -