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Genome of brown tide virus (AaV), the little giant of the Megaviridae, elucidates NCLDV genome expansion and host-virus coevolution.
Virology. 2014 Oct; 466-467:60-70.V

Abstract

Aureococcus anophagefferens causes economically and ecologically destructive "brown tides" in the United States, China and South Africa. Here we report the 370,920bp genomic sequence of AaV, a virus capable of infecting and lysing A. anophagefferens. AaV is a member of the nucleocytoplasmic large DNA virus (NCLDV) group, harboring 377 putative coding sequences and 8 tRNAs. Despite being an algal virus, AaV shows no phylogenetic affinity to the Phycodnaviridae family, to which most algae-infecting viruses belong. Core gene phylogenies, shared gene content and genome-wide similarities suggest AaV is the smallest member of the emerging clade "Megaviridae". The genomic architecture of AaV demonstrates that the ancestral virus had an even smaller genome, which expanded through gene duplication and assimilation of genes from diverse sources including the host itself - some of which probably modulate important host processes. AaV also harbors a number of genes exclusive to phycodnaviruses - reinforcing the hypothesis that Phycodna- and Mimiviridae share a common ancestor.

Authors+Show Affiliations

Department of Microbiology, The University of Tennessee, TN 37996, United States.Department of Microbiology, The University of Tennessee, TN 37996, United States.Institute of Marine and Coastal Sciences, Rutgers, NJ 08901, United States.School of Marine and Atmospheric Sciences, Stony Brook, NY 11794, United States.Institute of Marine and Coastal Sciences, Rutgers, NJ 08901, United States.Bigelow Lab for Ocean Sciences, Boothbay, ME 04544, United States.Department of Microbiology, The University of Tennessee, TN 37996, United States. Electronic address: wilhelm@utk.edu.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25035289

Citation

Moniruzzaman, Mohammad, et al. "Genome of Brown Tide Virus (AaV), the Little Giant of the Megaviridae, Elucidates NCLDV Genome Expansion and Host-virus Coevolution." Virology, vol. 466-467, 2014, pp. 60-70.
Moniruzzaman M, LeCleir GR, Brown CM, et al. Genome of brown tide virus (AaV), the little giant of the Megaviridae, elucidates NCLDV genome expansion and host-virus coevolution. Virology. 2014;466-467:60-70.
Moniruzzaman, M., LeCleir, G. R., Brown, C. M., Gobler, C. J., Bidle, K. D., Wilson, W. H., & Wilhelm, S. W. (2014). Genome of brown tide virus (AaV), the little giant of the Megaviridae, elucidates NCLDV genome expansion and host-virus coevolution. Virology, 466-467, 60-70. https://doi.org/10.1016/j.virol.2014.06.031
Moniruzzaman M, et al. Genome of Brown Tide Virus (AaV), the Little Giant of the Megaviridae, Elucidates NCLDV Genome Expansion and Host-virus Coevolution. Virology. 2014;466-467:60-70. PubMed PMID: 25035289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genome of brown tide virus (AaV), the little giant of the Megaviridae, elucidates NCLDV genome expansion and host-virus coevolution. AU - Moniruzzaman,Mohammad, AU - LeCleir,Gary R, AU - Brown,Christopher M, AU - Gobler,Christopher J, AU - Bidle,Kay D, AU - Wilson,William H, AU - Wilhelm,Steven W, Y1 - 2014/07/14/ PY - 2014/05/09/received PY - 2014/06/19/revised PY - 2014/06/21/accepted PY - 2014/7/19/entrez PY - 2014/7/19/pubmed PY - 2015/3/11/medline KW - AaV KW - Algal virus KW - Brown tides KW - Giant virus KW - Megaviridae KW - NCLDVs KW - Viral evolution SP - 60 EP - 70 JF - Virology JO - Virology VL - 466-467 N2 - Aureococcus anophagefferens causes economically and ecologically destructive "brown tides" in the United States, China and South Africa. Here we report the 370,920bp genomic sequence of AaV, a virus capable of infecting and lysing A. anophagefferens. AaV is a member of the nucleocytoplasmic large DNA virus (NCLDV) group, harboring 377 putative coding sequences and 8 tRNAs. Despite being an algal virus, AaV shows no phylogenetic affinity to the Phycodnaviridae family, to which most algae-infecting viruses belong. Core gene phylogenies, shared gene content and genome-wide similarities suggest AaV is the smallest member of the emerging clade "Megaviridae". The genomic architecture of AaV demonstrates that the ancestral virus had an even smaller genome, which expanded through gene duplication and assimilation of genes from diverse sources including the host itself - some of which probably modulate important host processes. AaV also harbors a number of genes exclusive to phycodnaviruses - reinforcing the hypothesis that Phycodna- and Mimiviridae share a common ancestor. SN - 1096-0341 UR - https://www.unboundmedicine.com/medline/citation/25035289/Genome_of_brown_tide_virus__AaV__the_little_giant_of_the_Megaviridae_elucidates_NCLDV_genome_expansion_and_host_virus_coevolution_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(14)00299-2 DB - PRIME DP - Unbound Medicine ER -