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Case report. Johanson-Blizzard syndrome: a report of gender-discordant twins with a novel UBR1 mutation.
Genet Mol Res. 2014 Jun 09; 13(2):4159-64.GM

Abstract

Johanson-Blizzard syndrome (JBS) is a rare autosomal recessive disorder resulting from loss-of-function mutations in the UBR1 gene. JBS can be easily recognized by its unique clinical presentation (including exocrine pancreatic insufficiency, hypoplasia/aplasia of the alae nasi, congenital scalp defects, sensorineural hearing loss, growth retardation, psychomotor retardation, and anal and genitourinary anomalies). The objective of this study is to report on the first familial case of gender-discordant twins presenting JBS and a novel mutation in the UBR1 gene. We also review literature describing molecularly confirmed cases of JBS. The female twin developed refractory severe diarrhea after the second month of life and died at the age of 3 months. The male twin also developed diarrhea and failure to thrive after the 3 month of life but improved when nutrition support and pancreatic enzyme replacement was started, and he has survived into adolescence. Both patients presented typical clinical features of JBS. A homozygous nonsense mutation (c.3682C>T; p.Q1228X) in UBR1 was confirmed. Severe presentation of JBS usually involves deleterious (nonsense, frameshift, or splice-site) mutations in the UBR1 gene that are thought to completely abolish the expression of a functional protein product, as in this familial case; however, milder presentation of JBS has occasionally been observed with missense mutations in at least 1 of the 2 copies of UBR1, in which there may be residual activity of the product of this gene. Early diagnosis and adequate treatment are crucial for a favorable outcome.

Authors+Show Affiliations

Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.Nursing School of North Sichuan Medical College, Nanchong, Sichuan, China.Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.No affiliation info availableNo affiliation info availableAffiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China chong.kim@icr.usp.br.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25036160

Citation

Quaio, C R., et al. "Case Report. Johanson-Blizzard Syndrome: a Report of Gender-discordant Twins With a Novel UBR1 Mutation." Genetics and Molecular Research : GMR, vol. 13, no. 2, 2014, pp. 4159-64.
Quaio CR, Koda YK, Bertola DR, et al. Case report. Johanson-Blizzard syndrome: a report of gender-discordant twins with a novel UBR1 mutation. Genet Mol Res. 2014;13(2):4159-64.
Quaio, C. R., Koda, Y. K., Bertola, D. R., Sukalo, M., Zenker, M., & Kim, C. A. (2014). Case report. Johanson-Blizzard syndrome: a report of gender-discordant twins with a novel UBR1 mutation. Genetics and Molecular Research : GMR, 13(2), 4159-64. https://doi.org/10.4238/2014.June.9.2
Quaio CR, et al. Case Report. Johanson-Blizzard Syndrome: a Report of Gender-discordant Twins With a Novel UBR1 Mutation. Genet Mol Res. 2014 Jun 9;13(2):4159-64. PubMed PMID: 25036160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case report. Johanson-Blizzard syndrome: a report of gender-discordant twins with a novel UBR1 mutation. AU - Quaio,C R, AU - Koda,Y K, AU - Bertola,D R, AU - Sukalo,M, AU - Zenker,M, AU - Kim,C A, Y1 - 2014/06/09/ PY - 2014/7/19/entrez PY - 2014/7/19/pubmed PY - 2015/3/7/medline SP - 4159 EP - 64 JF - Genetics and molecular research : GMR JO - Genet Mol Res VL - 13 IS - 2 N2 - Johanson-Blizzard syndrome (JBS) is a rare autosomal recessive disorder resulting from loss-of-function mutations in the UBR1 gene. JBS can be easily recognized by its unique clinical presentation (including exocrine pancreatic insufficiency, hypoplasia/aplasia of the alae nasi, congenital scalp defects, sensorineural hearing loss, growth retardation, psychomotor retardation, and anal and genitourinary anomalies). The objective of this study is to report on the first familial case of gender-discordant twins presenting JBS and a novel mutation in the UBR1 gene. We also review literature describing molecularly confirmed cases of JBS. The female twin developed refractory severe diarrhea after the second month of life and died at the age of 3 months. The male twin also developed diarrhea and failure to thrive after the 3 month of life but improved when nutrition support and pancreatic enzyme replacement was started, and he has survived into adolescence. Both patients presented typical clinical features of JBS. A homozygous nonsense mutation (c.3682C>T; p.Q1228X) in UBR1 was confirmed. Severe presentation of JBS usually involves deleterious (nonsense, frameshift, or splice-site) mutations in the UBR1 gene that are thought to completely abolish the expression of a functional protein product, as in this familial case; however, milder presentation of JBS has occasionally been observed with missense mutations in at least 1 of the 2 copies of UBR1, in which there may be residual activity of the product of this gene. Early diagnosis and adequate treatment are crucial for a favorable outcome. SN - 1676-5680 UR - https://www.unboundmedicine.com/medline/citation/25036160/Case_report__Johanson_Blizzard_syndrome:_a_report_of_gender_discordant_twins_with_a_novel_UBR1_mutation_ DB - PRIME DP - Unbound Medicine ER -