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Risk of dementia among patients with asthma: a nationwide longitudinal study.
J Am Med Dir Assoc. 2014 Oct; 15(10):763-7.JA

Abstract

BACKGROUND

Previous studies have suggested an association between asthma and dementia, but the results are still inconsistent.

METHODS

Using the Taiwan National Health Insurance Database, we enrolled 11,030 participants aged more than 45 years with asthma and 44,120 (1:4) age-/sex-matched controls between 1998 and 2008, and followed them to the end of 2011. Cases of any dementia or Alzheimer's disease that developed during the follow-up period were identified.

RESULTS

Asthma was associated with an increased risk of developing any dementia [hazard ratio (HR): 2.17, 95% confidence interval (CI): 1.87-2.52] and Alzheimer's disease (HR: 2.62, 95% CI: 1.71-4.02). Stratified by age, both asthma in midlife (>45 years and <65 years) and in late life (≥65 years) was associated with a greater likelihood of any dementia (HR: 2.48, 95% CI: 1.80-3.41; HR: 2.06, 95% CI: 1.74-2.44).

DISCUSSION

Asthma in midlife and in late life increased the risk of developing any dementia and Alzheimer's disease. The underlying mechanisms between asthma and dementia require further investigation.

Authors+Show Affiliations

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan.Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan.Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan.Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan.Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan.School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: tomsu0402@gmail.com.Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: ymbi@mail2000.com.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25037169

Citation

Chen, Mu-Hong, et al. "Risk of Dementia Among Patients With Asthma: a Nationwide Longitudinal Study." Journal of the American Medical Directors Association, vol. 15, no. 10, 2014, pp. 763-7.
Chen MH, Li CT, Tsai CF, et al. Risk of dementia among patients with asthma: a nationwide longitudinal study. J Am Med Dir Assoc. 2014;15(10):763-7.
Chen, M. H., Li, C. T., Tsai, C. F., Lin, W. C., Chang, W. H., Chen, T. J., Pan, T. L., Su, T. P., & Bai, Y. M. (2014). Risk of dementia among patients with asthma: a nationwide longitudinal study. Journal of the American Medical Directors Association, 15(10), 763-7. https://doi.org/10.1016/j.jamda.2014.06.003
Chen MH, et al. Risk of Dementia Among Patients With Asthma: a Nationwide Longitudinal Study. J Am Med Dir Assoc. 2014;15(10):763-7. PubMed PMID: 25037169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of dementia among patients with asthma: a nationwide longitudinal study. AU - Chen,Mu-Hong, AU - Li,Cheng-Ta, AU - Tsai,Chia-Fen, AU - Lin,Wei-Chen, AU - Chang,Wen-Han, AU - Chen,Tzeng-Ji, AU - Pan,Tai-Long, AU - Su,Tung-Ping, AU - Bai,Ya-Mei, Y1 - 2014/07/15/ PY - 2014/03/17/received PY - 2014/05/24/revised PY - 2014/06/03/accepted PY - 2014/7/20/entrez PY - 2014/7/20/pubmed PY - 2015/6/9/medline KW - Alzheimer's disease KW - Asthma KW - comorbidities KW - dementia SP - 763 EP - 7 JF - Journal of the American Medical Directors Association JO - J Am Med Dir Assoc VL - 15 IS - 10 N2 - BACKGROUND: Previous studies have suggested an association between asthma and dementia, but the results are still inconsistent. METHODS: Using the Taiwan National Health Insurance Database, we enrolled 11,030 participants aged more than 45 years with asthma and 44,120 (1:4) age-/sex-matched controls between 1998 and 2008, and followed them to the end of 2011. Cases of any dementia or Alzheimer's disease that developed during the follow-up period were identified. RESULTS: Asthma was associated with an increased risk of developing any dementia [hazard ratio (HR): 2.17, 95% confidence interval (CI): 1.87-2.52] and Alzheimer's disease (HR: 2.62, 95% CI: 1.71-4.02). Stratified by age, both asthma in midlife (>45 years and <65 years) and in late life (≥65 years) was associated with a greater likelihood of any dementia (HR: 2.48, 95% CI: 1.80-3.41; HR: 2.06, 95% CI: 1.74-2.44). DISCUSSION: Asthma in midlife and in late life increased the risk of developing any dementia and Alzheimer's disease. The underlying mechanisms between asthma and dementia require further investigation. SN - 1538-9375 UR - https://www.unboundmedicine.com/medline/citation/25037169/Risk_of_dementia_among_patients_with_asthma:_a_nationwide_longitudinal_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-8610(14)00344-2 DB - PRIME DP - Unbound Medicine ER -