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Analysis of ecstasy tablets using capillary electrophoresis with capacitively coupled contactless conductivity detection.
J Forensic Sci. 2014 Nov; 59(6):1622-6.JF

Abstract

A method for the identification of 3,4-methylenedioxymethamphetamine (MDMA) and meta-chlorophenylpiperazine (mCPP) was developed employing capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C(4) D). Sample extraction, separation, and detection of "Ecstasy" tablets were performed in <10 min without sample derivatization. The separation electrolyte was 20 mm TAPS/Lithium, pH 8.7. Average minimal detectable amounts for MDMA and mCPP were 0.04 mg/tablet, several orders of magnitude lower than the minimum amount encountered in a tablet. Seven different Ecstasy tablets seized in Rio de Janeiro, Brazil, were analyzed by CE-C(4) D and compared against routine gas chromatography-mass spectrometry (GC-MS). The CE method demonstrated sufficient selectivity to discriminate the two target drugs, MDMA and mCPP, from the other drugs present in seizures, namely amphepramone, fenproporex, caffeine, lidocaine, and cocaine. Separation was performed in <90 sec. The advantages of using C(4) D instead of traditional CE-UV methods for in-field analysis are also discussed.

Authors+Show Affiliations

Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, CEP 05508-000, São Paulo, SP, Brazil; Serviço de Perícias de Química, Instituto de Criminalística Carlos Éboli, R. Pedro I, 28, Rio de Janeiro, RJ, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25039689

Citation

Porto, Suely K S S., et al. "Analysis of Ecstasy Tablets Using Capillary Electrophoresis With Capacitively Coupled Contactless Conductivity Detection." Journal of Forensic Sciences, vol. 59, no. 6, 2014, pp. 1622-6.
Porto SK, Nogueira T, Blanes L, et al. Analysis of ecstasy tablets using capillary electrophoresis with capacitively coupled contactless conductivity detection. J Forensic Sci. 2014;59(6):1622-6.
Porto, S. K., Nogueira, T., Blanes, L., Doble, P., Sabino, B. D., do Lago, C. L., & Angnes, L. (2014). Analysis of ecstasy tablets using capillary electrophoresis with capacitively coupled contactless conductivity detection. Journal of Forensic Sciences, 59(6), 1622-6. https://doi.org/10.1111/1556-4029.12573
Porto SK, et al. Analysis of Ecstasy Tablets Using Capillary Electrophoresis With Capacitively Coupled Contactless Conductivity Detection. J Forensic Sci. 2014;59(6):1622-6. PubMed PMID: 25039689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of ecstasy tablets using capillary electrophoresis with capacitively coupled contactless conductivity detection. AU - Porto,Suely K S S, AU - Nogueira,Thiago, AU - Blanes,Lucas, AU - Doble,Philip, AU - Sabino,Bruno D, AU - do Lago,Claudimir L, AU - Angnes,Lúcio, Y1 - 2014/07/21/ PY - 2013/03/20/received PY - 2013/11/15/revised PY - 2013/12/01/accepted PY - 2014/7/22/entrez PY - 2014/7/22/pubmed PY - 2016/1/16/medline KW - 3,4-methylenedioxymethamphetamine KW - C4D KW - MDMA KW - capillary electrophoresis KW - contactless conductivity detection KW - forensic science KW - mCPP KW - meta-chlorophenylpiperazine SP - 1622 EP - 6 JF - Journal of forensic sciences JO - J. Forensic Sci. VL - 59 IS - 6 N2 - A method for the identification of 3,4-methylenedioxymethamphetamine (MDMA) and meta-chlorophenylpiperazine (mCPP) was developed employing capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C(4) D). Sample extraction, separation, and detection of "Ecstasy" tablets were performed in <10 min without sample derivatization. The separation electrolyte was 20 mm TAPS/Lithium, pH 8.7. Average minimal detectable amounts for MDMA and mCPP were 0.04 mg/tablet, several orders of magnitude lower than the minimum amount encountered in a tablet. Seven different Ecstasy tablets seized in Rio de Janeiro, Brazil, were analyzed by CE-C(4) D and compared against routine gas chromatography-mass spectrometry (GC-MS). The CE method demonstrated sufficient selectivity to discriminate the two target drugs, MDMA and mCPP, from the other drugs present in seizures, namely amphepramone, fenproporex, caffeine, lidocaine, and cocaine. Separation was performed in <90 sec. The advantages of using C(4) D instead of traditional CE-UV methods for in-field analysis are also discussed. SN - 1556-4029 UR - https://www.unboundmedicine.com/medline/citation/25039689/Analysis_of_ecstasy_tablets_using_capillary_electrophoresis_with_capacitively_coupled_contactless_conductivity_detection_ L2 - https://doi.org/10.1111/1556-4029.12573 DB - PRIME DP - Unbound Medicine ER -