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Microchimerism in the transfused obstetric population.
Vox Sang. 2014 Nov; 107(4):428-30.VS

Abstract

Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population.

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Authors+Show Affiliations

Bloch EM
Blood Systems Research Institute, San Francisco, CA, USA.
Busch MP
No affiliation info available
Lee TH
No affiliation info available
Montalvo L
No affiliation info available
Matthews Y
No affiliation info available
Bird A
No affiliation info available
Bruhn R
No affiliation info available
Stefan V
No affiliation info available

MeSH

AdultChimerismCohort StudiesFemaleHumansPeripartum PeriodPregnancyProspective StudiesTransfusion ReactionTransplantation ChimeraWounds and Injuries

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25040346

Citation

Bloch, E M., et al. "Microchimerism in the Transfused Obstetric Population." Vox Sanguinis, vol. 107, no. 4, 2014, pp. 428-30.
Bloch EM, Busch MP, Lee TH, et al. Microchimerism in the transfused obstetric population. Vox Sang. 2014;107(4):428-30.
Bloch, E. M., Busch, M. P., Lee, T. H., Montalvo, L., Matthews, Y., Bird, A., Bruhn, R., & Stefan, V. (2014). Microchimerism in the transfused obstetric population. Vox Sanguinis, 107(4), 428-30. https://doi.org/10.1111/vox.12177
Bloch EM, et al. Microchimerism in the Transfused Obstetric Population. Vox Sang. 2014;107(4):428-30. PubMed PMID: 25040346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microchimerism in the transfused obstetric population. AU - Bloch,E M, AU - Busch,M P, AU - Lee,T-H, AU - Montalvo,L, AU - Matthews,Y, AU - Bird,A, AU - Bruhn,R, AU - Stefan,V, Y1 - 2014/07/16/ PY - 2014/03/10/received PY - 2014/06/04/revised PY - 2014/06/11/accepted PY - 2014/7/22/entrez PY - 2014/7/22/pubmed PY - 2015/6/26/medline KW - blood transfusion KW - chimerism KW - peripartum SP - 428 EP - 30 JF - Vox sanguinis JO - Vox Sang VL - 107 IS - 4 N2 - Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population. SN - 1423-0410 UR - https://www.unboundmedicine.com/medline/citation/25040346/Microchimerism_in_the_transfused_obstetric_population_ L2 - https://doi.org/10.1111/vox.12177 DB - PRIME DP - Unbound Medicine ER -