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Microchimerism in the transfused obstetric population.
Vox Sang. 2014 Nov; 107(4):428-30.VS

Abstract

Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population.

Authors+Show Affiliations

Blood Systems Research Institute, San Francisco, CA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25040346

Citation

Bloch, E M., et al. "Microchimerism in the Transfused Obstetric Population." Vox Sanguinis, vol. 107, no. 4, 2014, pp. 428-30.
Bloch EM, Busch MP, Lee TH, et al. Microchimerism in the transfused obstetric population. Vox Sang. 2014;107(4):428-30.
Bloch, E. M., Busch, M. P., Lee, T. H., Montalvo, L., Matthews, Y., Bird, A., Bruhn, R., & Stefan, V. (2014). Microchimerism in the transfused obstetric population. Vox Sanguinis, 107(4), 428-30. https://doi.org/10.1111/vox.12177
Bloch EM, et al. Microchimerism in the Transfused Obstetric Population. Vox Sang. 2014;107(4):428-30. PubMed PMID: 25040346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microchimerism in the transfused obstetric population. AU - Bloch,E M, AU - Busch,M P, AU - Lee,T-H, AU - Montalvo,L, AU - Matthews,Y, AU - Bird,A, AU - Bruhn,R, AU - Stefan,V, Y1 - 2014/07/16/ PY - 2014/03/10/received PY - 2014/06/04/revised PY - 2014/06/11/accepted PY - 2014/7/22/entrez PY - 2014/7/22/pubmed PY - 2015/6/26/medline KW - blood transfusion KW - chimerism KW - peripartum SP - 428 EP - 30 JF - Vox sanguinis JO - Vox Sang VL - 107 IS - 4 N2 - Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population. SN - 1423-0410 UR - https://www.unboundmedicine.com/medline/citation/25040346/Microchimerism_in_the_transfused_obstetric_population_ L2 - https://doi.org/10.1111/vox.12177 DB - PRIME DP - Unbound Medicine ER -