Tags

Type your tag names separated by a space and hit enter

Recreational physical activity and risk of ovarian cancer: a meta-analysis.
Asian Pac J Cancer Prev 2014; 15(13):5161-6AP

Abstract

Our aim was to access the association between recreational physical activity (RPA) and risk of ovarian cancer (OC). The studies were retrieved from the PubMed and Embase databases up to February 20th, 2014. Risk ratios (OR) and 95% confidence intervals (CI) were used to estimate effect sizes. Random-effects or fixed-effects models were used to pool the data. The trim and fill method was applied for sensitivity analysis. Begg's rank correlation test and Egger's regression asymmetry test were employed to assess the publication bias. A total of 6 studies (435398 participants including 2983 OC patients) were included in this meta-analysis. The overall estimate indicated that there was weakly inverse association between RPA and OC risk (RR=0.90, 95%CI: 0.72-1.12, p=0.335). Meanwhile, for prospective cohort studies, a result consistent with the overall estimate was obtained (RR=1.12, 95% CI: 0.88-1.42, p=0.356). However, for case control studies, the pooled estimate of RR was 0.76 (95%CI: 0.64-0.90, p=0.002), indicating a clear significant association between RPA and OC risk. In addition, the sensitivity analysis indicated a significant link between RPA and risk of OC after removing Lahmann's study (RR=0.80, 95% CI: 0.68-0.93, p=0.004). No significant publication bias was found (Begg's test: p=1.00; Egger's test: p=0.817). In conclusion, our meta-analysis indicated a weakly inverse relationship between RPA and the occurrence of OC.

Authors+Show Affiliations

Competitive Sports School Affiliated to Harbin Institute of Physical Education, Heilongjiang, China E-mail : liminzhoulz@163.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25040968

Citation

Zhou, Li-Min. "Recreational Physical Activity and Risk of Ovarian Cancer: a Meta-analysis." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 15, no. 13, 2014, pp. 5161-6.
Zhou LM. Recreational physical activity and risk of ovarian cancer: a meta-analysis. Asian Pac J Cancer Prev. 2014;15(13):5161-6.
Zhou, L. M. (2014). Recreational physical activity and risk of ovarian cancer: a meta-analysis. Asian Pacific Journal of Cancer Prevention : APJCP, 15(13), pp. 5161-6.
Zhou LM. Recreational Physical Activity and Risk of Ovarian Cancer: a Meta-analysis. Asian Pac J Cancer Prev. 2014;15(13):5161-6. PubMed PMID: 25040968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recreational physical activity and risk of ovarian cancer: a meta-analysis. A1 - Zhou,Li-Min, PY - 2014/7/22/entrez PY - 2014/7/22/pubmed PY - 2015/4/8/medline SP - 5161 EP - 6 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 15 IS - 13 N2 - Our aim was to access the association between recreational physical activity (RPA) and risk of ovarian cancer (OC). The studies were retrieved from the PubMed and Embase databases up to February 20th, 2014. Risk ratios (OR) and 95% confidence intervals (CI) were used to estimate effect sizes. Random-effects or fixed-effects models were used to pool the data. The trim and fill method was applied for sensitivity analysis. Begg's rank correlation test and Egger's regression asymmetry test were employed to assess the publication bias. A total of 6 studies (435398 participants including 2983 OC patients) were included in this meta-analysis. The overall estimate indicated that there was weakly inverse association between RPA and OC risk (RR=0.90, 95%CI: 0.72-1.12, p=0.335). Meanwhile, for prospective cohort studies, a result consistent with the overall estimate was obtained (RR=1.12, 95% CI: 0.88-1.42, p=0.356). However, for case control studies, the pooled estimate of RR was 0.76 (95%CI: 0.64-0.90, p=0.002), indicating a clear significant association between RPA and OC risk. In addition, the sensitivity analysis indicated a significant link between RPA and risk of OC after removing Lahmann's study (RR=0.80, 95% CI: 0.68-0.93, p=0.004). No significant publication bias was found (Begg's test: p=1.00; Egger's test: p=0.817). In conclusion, our meta-analysis indicated a weakly inverse relationship between RPA and the occurrence of OC. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/25040968/Recreational_physical_activity_and_risk_of_ovarian_cancer:_a_meta_analysis_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:25040968&key=2014.15.13.5161 DB - PRIME DP - Unbound Medicine ER -