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The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case-control study, comorbidities, and meta-analysis of 16,786 subjects.
Bipolar Disord 2015; 17(1):27-38BD

Abstract

OBJECTIVES

The aim of this study was to evaluate the association of Val66Met brain-derived neurotrophic factor (BDNF) polymorphism with bipolar disorder in (i) a meta-analysis and (ii) a case-control study in a Mexican population. We also investigated the possible association of this polymorphism with clinical features.

METHODS

We performed a keyword search of the PubMed and Web of Science databases. A total of 22 studies that have investigated the association of Val66Met (rs6265) with bipolar disorder were selected for inclusion and combined with random effects meta-analysis, using allelic, additive, dominant, and recessive models. Finally, the single nucleotide polymorphism (rs6265) Val66Met in the BDNF gene was genotyped and compared between 139 patients with bipolar disorder and 141 healthy volunteers in a Mexican population.

RESULTS

The pooled results from the meta-analysis (9,349 cases and 7,437 controls) did not show a significant association in any of the models. The same results were obtained in our case-control study when analyzing the distribution of the genotypic frequencies of the Val66Met polymorphism in patients with bipolar disorder. However, when we analyzed the association between rs6265 and lifetime history of suicidal behavior, we found an association between genotype Val-Val and suicide attempt (p = 0.02).

CONCLUSIONS

Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder. However, in our case-control study in a Mexican population, the Val66Met polymorphism was associated with suicidal behavior in patients with bipolar disorder. Nevertheless, it is important to consider potential interactions of the BDNF gene, the environment, and different inheritance patterns, when carrying out future genetic studies with larger samples.

Authors+Show Affiliations

División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25041243

Citation

González-Castro, Thelma Beatriz, et al. "The Role of Brain-derived Neurotrophic Factor (BDNF) Val66Met Genetic Polymorphism in Bipolar Disorder: a Case-control Study, Comorbidities, and Meta-analysis of 16,786 Subjects." Bipolar Disorders, vol. 17, no. 1, 2015, pp. 27-38.
González-Castro TB, Nicolini H, Lanzagorta N, et al. The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case-control study, comorbidities, and meta-analysis of 16,786 subjects. Bipolar Disord. 2015;17(1):27-38.
González-Castro, T. B., Nicolini, H., Lanzagorta, N., López-Narváez, L., Genis, A., Pool García, S., & Tovilla-Zárate, C. A. (2015). The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case-control study, comorbidities, and meta-analysis of 16,786 subjects. Bipolar Disorders, 17(1), pp. 27-38. doi:10.1111/bdi.12227.
González-Castro TB, et al. The Role of Brain-derived Neurotrophic Factor (BDNF) Val66Met Genetic Polymorphism in Bipolar Disorder: a Case-control Study, Comorbidities, and Meta-analysis of 16,786 Subjects. Bipolar Disord. 2015;17(1):27-38. PubMed PMID: 25041243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of brain-derived neurotrophic factor (BDNF) Val66Met genetic polymorphism in bipolar disorder: a case-control study, comorbidities, and meta-analysis of 16,786 subjects. AU - González-Castro,Thelma Beatriz, AU - Nicolini,Humberto, AU - Lanzagorta,Nuria, AU - López-Narváez,Lilia, AU - Genis,Alma, AU - Pool García,Sherezada, AU - Tovilla-Zárate,Carlos Alfonso, Y1 - 2014/07/08/ PY - 2013/06/05/received PY - 2013/12/20/accepted PY - 2014/7/22/entrez PY - 2014/7/22/pubmed PY - 2016/4/19/medline KW - Mexican population KW - bipolar disorder KW - brain-derived neurotrophic factor (BDNF) gene KW - meta-analysis SP - 27 EP - 38 JF - Bipolar disorders JO - Bipolar Disord VL - 17 IS - 1 N2 - OBJECTIVES: The aim of this study was to evaluate the association of Val66Met brain-derived neurotrophic factor (BDNF) polymorphism with bipolar disorder in (i) a meta-analysis and (ii) a case-control study in a Mexican population. We also investigated the possible association of this polymorphism with clinical features. METHODS: We performed a keyword search of the PubMed and Web of Science databases. A total of 22 studies that have investigated the association of Val66Met (rs6265) with bipolar disorder were selected for inclusion and combined with random effects meta-analysis, using allelic, additive, dominant, and recessive models. Finally, the single nucleotide polymorphism (rs6265) Val66Met in the BDNF gene was genotyped and compared between 139 patients with bipolar disorder and 141 healthy volunteers in a Mexican population. RESULTS: The pooled results from the meta-analysis (9,349 cases and 7,437 controls) did not show a significant association in any of the models. The same results were obtained in our case-control study when analyzing the distribution of the genotypic frequencies of the Val66Met polymorphism in patients with bipolar disorder. However, when we analyzed the association between rs6265 and lifetime history of suicidal behavior, we found an association between genotype Val-Val and suicide attempt (p = 0.02). CONCLUSIONS: Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder. However, in our case-control study in a Mexican population, the Val66Met polymorphism was associated with suicidal behavior in patients with bipolar disorder. Nevertheless, it is important to consider potential interactions of the BDNF gene, the environment, and different inheritance patterns, when carrying out future genetic studies with larger samples. SN - 1399-5618 UR - https://www.unboundmedicine.com/medline/citation/25041243/The_role_of_brain_derived_neurotrophic_factor__BDNF__Val66Met_genetic_polymorphism_in_bipolar_disorder:_a_case_control_study_comorbidities_and_meta_analysis_of_16786_subjects_ L2 - https://doi.org/10.1111/bdi.12227 DB - PRIME DP - Unbound Medicine ER -