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Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.

Abstract

Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μg/L and 4.3 mg/L in cases and 85.6 μg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non-significant lower CRC risk (IRR = 0.92, 95% CI: 0.82-1.03 per 25 μg/L increase). However, sub-group analyses by sex showed a statistically significant association for women (p(trend) = 0.032; per 25 μg/L Se increase, IRR = 0.83, 95% CI: 0.70-0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (p(trend) = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95% CI: 0.82-0.98) with the association more apparent in women (p(trend) = 0.004; IRR = 0.82, 95% CI: 0.72-0.94 per 0.806 mg/L increase) than men (p(trend) = 0.485; IRR = 0.98, 95% CI: 0.86-1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.

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  • Authors+Show Affiliations

    ,

    Department of Physiology & Medical Physics & Centre for Systems Medicine, Royal College of Surgeons in Ireland, 31A York Street, Dublin 2, Ireland.

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    Source

    International journal of cancer 136:5 2015 Mar 01 pg 1149-61

    MeSH

    Adult
    Aged
    Biomarkers, Tumor
    Case-Control Studies
    Colorectal Neoplasms
    Europe
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Nutritional Status
    Prognosis
    Prospective Studies
    ROC Curve
    Risk Factors
    Selenium
    Selenoprotein P
    Spectrometry, X-Ray Emission

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25042282

    Citation

    Hughes, David J., et al. "Selenium Status Is Associated With Colorectal Cancer Risk in the European Prospective Investigation of Cancer and Nutrition Cohort." International Journal of Cancer, vol. 136, no. 5, 2015, pp. 1149-61.
    Hughes DJ, Fedirko V, Jenab M, et al. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Int J Cancer. 2015;136(5):1149-61.
    Hughes, D. J., Fedirko, V., Jenab, M., Schomburg, L., Méplan, C., Freisling, H., ... Hesketh, J. E. (2015). Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. International Journal of Cancer, 136(5), pp. 1149-61. doi:10.1002/ijc.29071.
    Hughes DJ, et al. Selenium Status Is Associated With Colorectal Cancer Risk in the European Prospective Investigation of Cancer and Nutrition Cohort. Int J Cancer. 2015 Mar 1;136(5):1149-61. PubMed PMID: 25042282.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. AU - Hughes,David J, AU - Fedirko,Veronika, AU - Jenab,Mazda, AU - Schomburg,Lutz, AU - Méplan,Catherine, AU - Freisling,Heinz, AU - Bueno-de-Mesquita,H B as, AU - Hybsier,Sandra, AU - Becker,Niels-Peter, AU - Czuban,Magdalena, AU - Tjønneland,Anne, AU - Outzen,Malene, AU - Boutron-Ruault,Marie-Christine, AU - Racine,Antoine, AU - Bastide,Nadia, AU - Kühn,Tilman, AU - Kaaks,Rudolf, AU - Trichopoulos,Dimitrios, AU - Trichopoulou,Antonia, AU - Lagiou,Pagona, AU - Panico,Salvatore, AU - Peeters,Petra H, AU - Weiderpass,Elisabete, AU - Skeie,Guri, AU - Dagrun,Engeset, AU - Chirlaque,Maria-Dolores, AU - Sánchez,Maria-Jose, AU - Ardanaz,Eva, AU - Ljuslinder,Ingrid, AU - Wennberg,Maria, AU - Bradbury,Kathryn E, AU - Vineis,Paolo, AU - Naccarati,Alessio, AU - Palli,Domenico, AU - Boeing,Heiner, AU - Overvad,Kim, AU - Dorronsoro,Miren, AU - Jakszyn,Paula, AU - Cross,Amanda J, AU - Quirós,Jose Ramón, AU - Stepien,Magdalena, AU - Kong,So Yeon, AU - Duarte-Salles,Talita, AU - Riboli,Elio, AU - Hesketh,John E, Y1 - 2014/07/21/ PY - 2014/04/24/received PY - 2014/06/13/accepted PY - 2014/7/22/entrez PY - 2014/7/22/pubmed PY - 2015/2/27/medline KW - colorectal neoplasms KW - prospective cohort KW - selenium KW - selenium status KW - selenoprotein P SP - 1149 EP - 61 JF - International journal of cancer JO - Int. J. Cancer VL - 136 IS - 5 N2 - Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μg/L and 4.3 mg/L in cases and 85.6 μg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non-significant lower CRC risk (IRR = 0.92, 95% CI: 0.82-1.03 per 25 μg/L increase). However, sub-group analyses by sex showed a statistically significant association for women (p(trend) = 0.032; per 25 μg/L Se increase, IRR = 0.83, 95% CI: 0.70-0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (p(trend) = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95% CI: 0.82-0.98) with the association more apparent in women (p(trend) = 0.004; IRR = 0.82, 95% CI: 0.72-0.94 per 0.806 mg/L increase) than men (p(trend) = 0.485; IRR = 0.98, 95% CI: 0.86-1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/25042282/Selenium_status_is_associated_with_colorectal_cancer_risk_in_the_European_prospective_investigation_of_cancer_and_nutrition_cohort_ L2 - https://doi.org/10.1002/ijc.29071 DB - PRIME DP - Unbound Medicine ER -