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Vitamin D and chronic kidney disease.
Korean J Intern Med. 2014 Jul; 29(4):416-27.KJ

Abstract

Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse correlation with kidney function. Growing evidence has indicated that vitamin D deficiency may contribute to deteriorating renal function, as well as increased morbidity and mortality in patients with CKD. Recent studies have suggested that treatment with active vitamin D or its analogues can ameliorate renal injury by reducing fibrosis, apoptosis, and inflammation in animal models; this treatment also decreases proteinuria and mortality in patients with CKD. These renoprotective effects of vitamin D treatment are far beyond its classical role in the maintenance of bone and mineral metabolism, in addition to its pleiotropic effects on extra-mineral metabolism. In this review, we discuss the altered metabolism of vitamin D in kidney disease, and the potential renoprotective mechanisms of vitamin D in experimental and clinical studies. In addition, issues regarding the effects of vitamin D treatment on clinical outcomes are discussed.

Authors+Show Affiliations

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25045287

Citation

Kim, Chang Seong, and Soo Wan Kim. "Vitamin D and Chronic Kidney Disease." The Korean Journal of Internal Medicine, vol. 29, no. 4, 2014, pp. 416-27.
Kim CS, Kim SW. Vitamin D and chronic kidney disease. Korean J Intern Med. 2014;29(4):416-27.
Kim, C. S., & Kim, S. W. (2014). Vitamin D and chronic kidney disease. The Korean Journal of Internal Medicine, 29(4), 416-27. https://doi.org/10.3904/kjim.2014.29.4.416
Kim CS, Kim SW. Vitamin D and Chronic Kidney Disease. Korean J Intern Med. 2014;29(4):416-27. PubMed PMID: 25045287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and chronic kidney disease. AU - Kim,Chang Seong, AU - Kim,Soo Wan, Y1 - 2014/06/27/ PY - 2014/05/10/received PY - 2014/05/23/accepted PY - 2014/7/22/entrez PY - 2014/7/22/pubmed PY - 2015/8/19/medline KW - Cardiovascular diseases KW - Mortality KW - Renal insufficiency, chronic KW - Vitamin D SP - 416 EP - 27 JF - The Korean journal of internal medicine JO - Korean J Intern Med VL - 29 IS - 4 N2 - Chronic kidney disease (CKD) has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Vitamin D deficiency or insufficiency is common in patients with CKD, and serum levels of vitamin D appear to have an inverse correlation with kidney function. Growing evidence has indicated that vitamin D deficiency may contribute to deteriorating renal function, as well as increased morbidity and mortality in patients with CKD. Recent studies have suggested that treatment with active vitamin D or its analogues can ameliorate renal injury by reducing fibrosis, apoptosis, and inflammation in animal models; this treatment also decreases proteinuria and mortality in patients with CKD. These renoprotective effects of vitamin D treatment are far beyond its classical role in the maintenance of bone and mineral metabolism, in addition to its pleiotropic effects on extra-mineral metabolism. In this review, we discuss the altered metabolism of vitamin D in kidney disease, and the potential renoprotective mechanisms of vitamin D in experimental and clinical studies. In addition, issues regarding the effects of vitamin D treatment on clinical outcomes are discussed. SN - 2005-6648 UR - https://www.unboundmedicine.com/medline/citation/25045287/Vitamin_D_and_chronic_kidney_disease_ L2 - https://dx.doi.org/10.3904/kjim.2014.29.4.416 DB - PRIME DP - Unbound Medicine ER -