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Nut consumption and the risk of coronary artery disease: a dose-response meta-analysis of 13 prospective studies.

Abstract

INTRODUCTION

Epidemiological studies evaluating the association of nut with risk of coronary artery disease (CAD) have produced inconsistent results. We conducted a meta-analysis to summarize the evidence from prospective cohort studies regarding the association between nut consumption and risk of CAD.

MATERIALS AND METHODS

Pertinent studies were identified by searching Web of Knowledge, Pubmed and Wan Fang Med Online up to January 2014. Random-effect model was used to combine the results. Dose-response relationship was assessed by restricted cubic spline. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test.

RESULTS

Nine articles with 13 prospective studies involving 6,127 CAD cases and 347,477 participants were included in this meta-analysis. Pooled results suggested that highest nut consumption amount versus lowest amount was significantly associated with the risk of CAD [summary relative risk (RR)=0.660, 95%CI=0.581-0.748, I(2)=39.6%]. Linear dose-response relationship was found between nut consumption and CAD risk, and the risk of CAD decreased by 5% for every 1 serving/week increase intake of nut. A protective effect for CAD was found when consumed more than 2 servings/week of nut. The RR of CAD was 0.96 (0.89-1.02), 0.91 (0.82-0.99), 0.85 (0.77-0.95), 0.80 (0.72-0.89), 0.75 (0.65- 0.85) and 0.70 (0.58-0.83) for 1, 2, 3, 4, 5 and 6 servings/week of nut consumption, respectively.

CONCLUSIONS

Our analysis indicated that nut consumption has a protective effect on CAD.

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  • Authors+Show Affiliations

    ,

    Department of Cardiology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730050, China.

    ,

    Department of Cardiology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730050, China.

    ,

    Department of Cardiology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730050, China.

    ,

    Department of Cardiology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730050, China.

    ,

    Department of Cardiology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730050, China.

    Department of Cardiology, Lanzhou General Hospital of Lanzhou Military Region, Lanzhou, Gansu 730050, China. Electronic address: zhangzwz@medmail.com.cn.

    Source

    Thrombosis research 134:4 2014 Oct pg 790-4

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Coronary Artery Disease
    Feeding Behavior
    Female
    Humans
    Male
    Middle Aged
    Nuts
    Prospective Studies
    Risk Factors
    Young Adult

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    25047173

    Citation

    Ma, Ling, et al. "Nut Consumption and the Risk of Coronary Artery Disease: a Dose-response Meta-analysis of 13 Prospective Studies." Thrombosis Research, vol. 134, no. 4, 2014, pp. 790-4.
    Ma L, Wang F, Guo W, et al. Nut consumption and the risk of coronary artery disease: a dose-response meta-analysis of 13 prospective studies. Thromb Res. 2014;134(4):790-4.
    Ma, L., Wang, F., Guo, W., Yang, H., Liu, Y., & Zhang, W. (2014). Nut consumption and the risk of coronary artery disease: a dose-response meta-analysis of 13 prospective studies. Thrombosis Research, 134(4), pp. 790-4. doi:10.1016/j.thromres.2014.06.017.
    Ma L, et al. Nut Consumption and the Risk of Coronary Artery Disease: a Dose-response Meta-analysis of 13 Prospective Studies. Thromb Res. 2014;134(4):790-4. PubMed PMID: 25047173.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nut consumption and the risk of coronary artery disease: a dose-response meta-analysis of 13 prospective studies. AU - Ma,Ling, AU - Wang,Fei, AU - Guo,Wenyun, AU - Yang,Hongning, AU - Liu,Yan, AU - Zhang,Weize, Y1 - 2014/07/05/ PY - 2014/03/20/received PY - 2014/06/07/revised PY - 2014/06/30/accepted PY - 2014/7/23/entrez PY - 2014/7/23/pubmed PY - 2015/5/28/medline KW - Coronary artery disease KW - Dose–response meta-analysis KW - Nut consumption SP - 790 EP - 4 JF - Thrombosis research JO - Thromb. Res. VL - 134 IS - 4 N2 - INTRODUCTION: Epidemiological studies evaluating the association of nut with risk of coronary artery disease (CAD) have produced inconsistent results. We conducted a meta-analysis to summarize the evidence from prospective cohort studies regarding the association between nut consumption and risk of CAD. MATERIALS AND METHODS: Pertinent studies were identified by searching Web of Knowledge, Pubmed and Wan Fang Med Online up to January 2014. Random-effect model was used to combine the results. Dose-response relationship was assessed by restricted cubic spline. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test. RESULTS: Nine articles with 13 prospective studies involving 6,127 CAD cases and 347,477 participants were included in this meta-analysis. Pooled results suggested that highest nut consumption amount versus lowest amount was significantly associated with the risk of CAD [summary relative risk (RR)=0.660, 95%CI=0.581-0.748, I(2)=39.6%]. Linear dose-response relationship was found between nut consumption and CAD risk, and the risk of CAD decreased by 5% for every 1 serving/week increase intake of nut. A protective effect for CAD was found when consumed more than 2 servings/week of nut. The RR of CAD was 0.96 (0.89-1.02), 0.91 (0.82-0.99), 0.85 (0.77-0.95), 0.80 (0.72-0.89), 0.75 (0.65- 0.85) and 0.70 (0.58-0.83) for 1, 2, 3, 4, 5 and 6 servings/week of nut consumption, respectively. CONCLUSIONS: Our analysis indicated that nut consumption has a protective effect on CAD. SN - 1879-2472 UR - https://www.unboundmedicine.com/medline/citation/25047173/Nut_consumption_and_the_risk_of_coronary_artery_disease:_a_dose_response_meta_analysis_of_13_prospective_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(14)00343-0 DB - PRIME DP - Unbound Medicine ER -