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Vitamin A intake and risk of melanoma: a meta-analysis.
PLoS One 2014; 9(7):e102527Plos

Abstract

BACKGROUND

Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the association by performing a meta-analysis.

METHODS

Eligible studies were identified by searching PubMed and EMBASE databases, as well as by reviewing the references of retrieved publications. Summary odds ratios (OR) with corresponding 95% confidence interval (CI) were computed with a random-effects model. Study-specific ORs and 95% CIs for the highest vs. lowest categories of vitamin A intake were pooled.

RESULTS

A total of 8 case-control studies and 2 prospective studies comprising 3,328 melanoma cases and 233,295 non-case subjects were included. The summary OR for the highest compared with the lowest intake of total vitamin A, retinol and beta-carotene was 0.86 (95% CI = 0.59-1.25), 0.80 (95% CI = 0.69-0.92) and 0.87 (95%CI = 0.62-1.20), respectively. Significant heterogeneity was observed among studies on vitamin A and beta-carotene intake, but not among studies on retinol intake. Subgroup and sensitivity analyses confirmed these findings. There was no indication of publication bias.

CONCLUSION

Findings from this meta-analysis suggest that intake of retinol, rather than of total vitamin A or beta-carotene, is significantly associated with reduced risk of melanoma.

Authors+Show Affiliations

Department of Dermatology, Liaocheng People's Hospital, Liaocheng, China.Department of Clinical Laboratory, Liaocheng People's Hospital, Liaocheng, China.Department of Gynaecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25048246

Citation

Zhang, Yun-Ping, et al. "Vitamin a Intake and Risk of Melanoma: a Meta-analysis." PloS One, vol. 9, no. 7, 2014, pp. e102527.
Zhang YP, Chu RX, Liu H. Vitamin A intake and risk of melanoma: a meta-analysis. PLoS ONE. 2014;9(7):e102527.
Zhang, Y. P., Chu, R. X., & Liu, H. (2014). Vitamin A intake and risk of melanoma: a meta-analysis. PloS One, 9(7), pp. e102527. doi:10.1371/journal.pone.0102527.
Zhang YP, Chu RX, Liu H. Vitamin a Intake and Risk of Melanoma: a Meta-analysis. PLoS ONE. 2014;9(7):e102527. PubMed PMID: 25048246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin A intake and risk of melanoma: a meta-analysis. AU - Zhang,Yun-Ping, AU - Chu,Rui-Xue, AU - Liu,Hui, Y1 - 2014/07/21/ PY - 2014/03/04/received PY - 2014/06/18/accepted PY - 2014/7/23/entrez PY - 2014/7/23/pubmed PY - 2015/4/8/medline SP - e102527 EP - e102527 JF - PloS one JO - PLoS ONE VL - 9 IS - 7 N2 - BACKGROUND: Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the association by performing a meta-analysis. METHODS: Eligible studies were identified by searching PubMed and EMBASE databases, as well as by reviewing the references of retrieved publications. Summary odds ratios (OR) with corresponding 95% confidence interval (CI) were computed with a random-effects model. Study-specific ORs and 95% CIs for the highest vs. lowest categories of vitamin A intake were pooled. RESULTS: A total of 8 case-control studies and 2 prospective studies comprising 3,328 melanoma cases and 233,295 non-case subjects were included. The summary OR for the highest compared with the lowest intake of total vitamin A, retinol and beta-carotene was 0.86 (95% CI = 0.59-1.25), 0.80 (95% CI = 0.69-0.92) and 0.87 (95%CI = 0.62-1.20), respectively. Significant heterogeneity was observed among studies on vitamin A and beta-carotene intake, but not among studies on retinol intake. Subgroup and sensitivity analyses confirmed these findings. There was no indication of publication bias. CONCLUSION: Findings from this meta-analysis suggest that intake of retinol, rather than of total vitamin A or beta-carotene, is significantly associated with reduced risk of melanoma. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25048246/Vitamin_A_intake_and_risk_of_melanoma:_a_meta_analysis_ L2 - http://dx.plos.org/10.1371/journal.pone.0102527 DB - PRIME DP - Unbound Medicine ER -