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Vitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trial.
Pediatr Exerc Sci 2015; 27(1):113-9PE

Abstract

Observational studies identified associations between vitamin D insufficiency (serum 25(OH)D < 30ng·ml-1) and risk of upper respiratory infection (URI). Swimmers are highly prone to URIs, which might hinder their performance. The aim of this study was to examine if vitamin D3 supplementation reduces URI burden in vitamin D-insufficient swimmers. Fifty-five competitive adolescent swimmers with vitamin D insufficiency were randomized to receive vitamin D3 (2,000IU·d-1) or placebo for 12 winter weeks. A URI symptom questionnaire was completed weekly. Serum 25(OH)D concentrations were measured by radio-immunoassay before and after supplementation. We used linear regression to examine the relation between the change in 25(OH)D concentrations during the trial, and the duration and severity of URIs. There were no between-group differences in the frequency, severity, or duration of URIs. Exploratory analyses revealed that in the placebo group only, the change in 25(OH)D concentrations during the trial was highly associated with the duration of URIs (r = -0.90,p < .001), and moderately associated with the severity of URIs (r = -0.65,p = .043). The between-group differences for duration were highly significant. Vitamin D3 supplementation in adolescent swimmers with vitamin D insufficiency did not reduce URI burden. However, larger decreases in serum 25(OH)D concentrations were associated with significantly longer and more severe URI episodes.

Authors+Show Affiliations

Exercise, Lifestyle and Nutrition Clinic, Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25050610

Citation

Dubnov-Raz, Gal, et al. "Vitamin D Supplementation and Upper Respiratory Tract Infections in Adolescent Swimmers: a Randomized Controlled Trial." Pediatric Exercise Science, vol. 27, no. 1, 2015, pp. 113-9.
Dubnov-Raz G, Rinat B, Hemilä H, et al. Vitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trial. Pediatr Exerc Sci. 2015;27(1):113-9.
Dubnov-Raz, G., Rinat, B., Hemilä, H., Choleva, L., Cohen, A. H., & Constantini, N. W. (2015). Vitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trial. Pediatric Exercise Science, 27(1), pp. 113-9. doi:10.1123/pes.2014-0030.
Dubnov-Raz G, et al. Vitamin D Supplementation and Upper Respiratory Tract Infections in Adolescent Swimmers: a Randomized Controlled Trial. Pediatr Exerc Sci. 2015;27(1):113-9. PubMed PMID: 25050610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trial. AU - Dubnov-Raz,Gal, AU - Rinat,Barak, AU - Hemilä,Harri, AU - Choleva,Lauryn, AU - Cohen,Avner H, AU - Constantini,Naama W, Y1 - 2014/07/15/ PY - 2014/7/23/entrez PY - 2014/7/23/pubmed PY - 2016/3/25/medline SP - 113 EP - 9 JF - Pediatric exercise science JO - Pediatr Exerc Sci VL - 27 IS - 1 N2 - Observational studies identified associations between vitamin D insufficiency (serum 25(OH)D < 30ng·ml-1) and risk of upper respiratory infection (URI). Swimmers are highly prone to URIs, which might hinder their performance. The aim of this study was to examine if vitamin D3 supplementation reduces URI burden in vitamin D-insufficient swimmers. Fifty-five competitive adolescent swimmers with vitamin D insufficiency were randomized to receive vitamin D3 (2,000IU·d-1) or placebo for 12 winter weeks. A URI symptom questionnaire was completed weekly. Serum 25(OH)D concentrations were measured by radio-immunoassay before and after supplementation. We used linear regression to examine the relation between the change in 25(OH)D concentrations during the trial, and the duration and severity of URIs. There were no between-group differences in the frequency, severity, or duration of URIs. Exploratory analyses revealed that in the placebo group only, the change in 25(OH)D concentrations during the trial was highly associated with the duration of URIs (r = -0.90,p < .001), and moderately associated with the severity of URIs (r = -0.65,p = .043). The between-group differences for duration were highly significant. Vitamin D3 supplementation in adolescent swimmers with vitamin D insufficiency did not reduce URI burden. However, larger decreases in serum 25(OH)D concentrations were associated with significantly longer and more severe URI episodes. SN - 1543-2920 UR - https://www.unboundmedicine.com/medline/citation/25050610/Vitamin_D_supplementation_and_upper_respiratory_tract_infections_in_adolescent_swimmers:_a_randomized_controlled_trial_ L2 - https://journals.humankinetics.com/doi/10.1123/pes.2014-0030 DB - PRIME DP - Unbound Medicine ER -