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[Light-chain deposition disease. Presentation of a case].
Pathologica. 1989 Mar-Apr; 81(1072):203-11.P

Abstract

A case of 66-years-old woman with mild renal failure due to deposition of K light chains on glomerular nodules, is reported. Monoclonal K light chains were found by immunofixation in serum and concentrated urine. Bone marrow examination showed a moderate increase of plasma cells, all stained for K light chains. Amyloid was not identified. No chemotherapy was started. Despite this, in the 15-months follow-up, renal function was preserved; no signs of myeloma, nor of extrarenal involvement were found. Careful follow-up is emphasized. The reason why light chains form amyloidoses or nodular deposits, like diabetic glomerulosclerosis of Kimmelstiel-Wilson, is briefly discussed, together with the differential diagnosis from other nephropathies.

Authors

Bertoli G
No affiliation info available
Ghiringhelli P
No affiliation info available
Bersiga A
No affiliation info available
Pecchini F
No affiliation info available
Betri E
No affiliation info available

MeSH

AgedAmyloidosisBone MarrowDiagnosis, DifferentialFemaleGlomerulonephritisHumansHypergammaglobulinemiaImmunoglobulin kappa-ChainsKidney GlomerulusMultiple Myeloma

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ita

PubMed ID

2505215

Citation

Bertoli, G, et al. "[Light-chain Deposition Disease. Presentation of a Case]." Pathologica, vol. 81, no. 1072, 1989, pp. 203-11.
Bertoli G, Ghiringhelli P, Bersiga A, et al. [Light-chain deposition disease. Presentation of a case]. Pathologica. 1989;81(1072):203-11.
Bertoli, G., Ghiringhelli, P., Bersiga, A., Pecchini, F., & Betri, E. (1989). [Light-chain deposition disease. Presentation of a case]. Pathologica, 81(1072), 203-11.
Bertoli G, et al. [Light-chain Deposition Disease. Presentation of a Case]. Pathologica. 1989 Mar-Apr;81(1072):203-11. PubMed PMID: 2505215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Light-chain deposition disease. Presentation of a case]. AU - Bertoli,G, AU - Ghiringhelli,P, AU - Bersiga,A, AU - Pecchini,F, AU - Betri,E, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 203 EP - 11 JF - Pathologica JO - Pathologica VL - 81 IS - 1072 N2 - A case of 66-years-old woman with mild renal failure due to deposition of K light chains on glomerular nodules, is reported. Monoclonal K light chains were found by immunofixation in serum and concentrated urine. Bone marrow examination showed a moderate increase of plasma cells, all stained for K light chains. Amyloid was not identified. No chemotherapy was started. Despite this, in the 15-months follow-up, renal function was preserved; no signs of myeloma, nor of extrarenal involvement were found. Careful follow-up is emphasized. The reason why light chains form amyloidoses or nodular deposits, like diabetic glomerulosclerosis of Kimmelstiel-Wilson, is briefly discussed, together with the differential diagnosis from other nephropathies. SN - 0031-2983 UR - https://www.unboundmedicine.com/medline/citation/2505215/[Light_chain_deposition_disease__Presentation_of_a_case]_ L2 - http://www.diseaseinfosearch.org/result/4223 DB - PRIME DP - Unbound Medicine ER -