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Associations of non-high density lipoprotein cholesterol and traditional blood lipid profiles with hyperuricemia among middle-aged and elderly Chinese people: a community-based cross-sectional study.
Lipids Health Dis. 2014 Jul 23; 13:117.LH

Abstract

BACKGROUND

Increased serum uric acid (SUA) is associated with dyslipidemia. However, there are conflicting data about the role of single lipid species including non-high density lipoprotein cholesterol (non-HDL-C) in promoting SUA accumulation. Here, we aimed to compare non-HDL-C with other traditional blood lipid profiles in relation to hyperuricemia in a middle-aged and elderly Chinese population.

METHODS

Data was collected from 9580 participants undergoing routine physical examinations in Xiangcheng district of Suzhou. SUA, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were examined for all participants. Non-HDL-C was calculated by subtracting HDL-C from TC. The associations of blood lipid profiles with hyperuricemia were examined in men and women, respectively. The areas under Receiver Operating Characteristic (ROC) curves (AUCs) were compared to assess the discriminatory value of blood lipid parameters for predicting hyperuricemia.

RESULTS

All blood lipid parameters significantly correlated with SUA (all P values <0.001). The correlation coefficient between SUA and TG was the highest in both genders. The correlation coefficient of non-HDL-C was higher than HDL-C in males and was higher than TC and LDL-C but followed HDL-C in females. In male group, AUC of TG (0.659) was greater than that of non-HDL-C (0.595) (P values <0.001). The AUC values of HDL-C, TC and LDL-C were lower; respectively 0.581, 0.559 and 0.552. In female group, AUC was highest for TG (0.678) followed by HDL-C (0.616), non-HDL-C (0.610), LDL-C (0.559) and TC (0.557) (all P values<0.001).

CONCLUSIONS

In both genders, serum TG has the strongest association with hyperuricemia among blood lipid parameters. Non-HDL-C is also significantly associated with hyperuricemia.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDepartment of Epidemiology, School of Public Health, Medical College of Soochow, 199 Ren-ai Road, Industrial Park District, Suzhou 215123, China. yhzhang@suda.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25052552

Citation

Xu, Juan, et al. "Associations of Non-high Density Lipoprotein Cholesterol and Traditional Blood Lipid Profiles With Hyperuricemia Among Middle-aged and Elderly Chinese People: a Community-based Cross-sectional Study." Lipids in Health and Disease, vol. 13, 2014, p. 117.
Xu J, Peng H, Ma Q, et al. Associations of non-high density lipoprotein cholesterol and traditional blood lipid profiles with hyperuricemia among middle-aged and elderly Chinese people: a community-based cross-sectional study. Lipids Health Dis. 2014;13:117.
Xu, J., Peng, H., Ma, Q., Zhou, X., Xu, W., Huang, L., Hu, J., & Zhang, Y. (2014). Associations of non-high density lipoprotein cholesterol and traditional blood lipid profiles with hyperuricemia among middle-aged and elderly Chinese people: a community-based cross-sectional study. Lipids in Health and Disease, 13, 117. https://doi.org/10.1186/1476-511X-13-117
Xu J, et al. Associations of Non-high Density Lipoprotein Cholesterol and Traditional Blood Lipid Profiles With Hyperuricemia Among Middle-aged and Elderly Chinese People: a Community-based Cross-sectional Study. Lipids Health Dis. 2014 Jul 23;13:117. PubMed PMID: 25052552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of non-high density lipoprotein cholesterol and traditional blood lipid profiles with hyperuricemia among middle-aged and elderly Chinese people: a community-based cross-sectional study. AU - Xu,Juan, AU - Peng,Hao, AU - Ma,Qinghua, AU - Zhou,Xiaohua, AU - Xu,Wenxin, AU - Huang,Liang, AU - Hu,Jiarong, AU - Zhang,Yonghong, Y1 - 2014/07/23/ PY - 2014/04/11/received PY - 2014/07/17/accepted PY - 2014/7/24/entrez PY - 2014/7/24/pubmed PY - 2015/3/31/medline SP - 117 EP - 117 JF - Lipids in health and disease JO - Lipids Health Dis VL - 13 N2 - BACKGROUND: Increased serum uric acid (SUA) is associated with dyslipidemia. However, there are conflicting data about the role of single lipid species including non-high density lipoprotein cholesterol (non-HDL-C) in promoting SUA accumulation. Here, we aimed to compare non-HDL-C with other traditional blood lipid profiles in relation to hyperuricemia in a middle-aged and elderly Chinese population. METHODS: Data was collected from 9580 participants undergoing routine physical examinations in Xiangcheng district of Suzhou. SUA, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were examined for all participants. Non-HDL-C was calculated by subtracting HDL-C from TC. The associations of blood lipid profiles with hyperuricemia were examined in men and women, respectively. The areas under Receiver Operating Characteristic (ROC) curves (AUCs) were compared to assess the discriminatory value of blood lipid parameters for predicting hyperuricemia. RESULTS: All blood lipid parameters significantly correlated with SUA (all P values <0.001). The correlation coefficient between SUA and TG was the highest in both genders. The correlation coefficient of non-HDL-C was higher than HDL-C in males and was higher than TC and LDL-C but followed HDL-C in females. In male group, AUC of TG (0.659) was greater than that of non-HDL-C (0.595) (P values <0.001). The AUC values of HDL-C, TC and LDL-C were lower; respectively 0.581, 0.559 and 0.552. In female group, AUC was highest for TG (0.678) followed by HDL-C (0.616), non-HDL-C (0.610), LDL-C (0.559) and TC (0.557) (all P values<0.001). CONCLUSIONS: In both genders, serum TG has the strongest association with hyperuricemia among blood lipid parameters. Non-HDL-C is also significantly associated with hyperuricemia. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/25052552/Associations_of_non_high_density_lipoprotein_cholesterol_and_traditional_blood_lipid_profiles_with_hyperuricemia_among_middle_aged_and_elderly_Chinese_people:_a_community_based_cross_sectional_study_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-117 DB - PRIME DP - Unbound Medicine ER -