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Patterns of abstinence or continued drug use among methadone maintenance patients and their relation to treatment retention.
J Psychoactive Drugs. 2014 Apr-Jun; 46(2):114-22.JP

Abstract

The efficacy and effectiveness of methadone maintenance treatment (MMT) in the medical management of opioid addiction has been well-established, but treatment outcomes are compromised by the continued use of licit and illicit drugs during MMT. The present study examined the relationship between in-treatment illicit drug use and retention and dropout of 604 MMT patients in Washington, D.C. Sixty-eight percent of patients did not test positive for an unprescribed drug during the study period. Of patients who tested positive for an illicit drug during the baseline period, 55% tested positive for cocaine, 44% for opiates, 23% for THC, 20% for benzodiazepines, 7% for PCP, and 4% for amphetamines. Those testing positive were three times more likely to leave treatment than those who did not test positive. Testing positive for one drug doubled the rate of attrition; testing positive for multiple drugs quadrupled the risk of attrition. Non-prescribed opioid or benzodiazepine use was a predictor of MMT dropout, but prescribed opioid or benzodiazepine use was not. Continued illicit drug use poses significant risk for subsequent premature termination of MMT. Assertive clinical management of continued illicit drug use could provide mechanisms to enhance MMT retention and long-term recovery outcomes.

Authors+Show Affiliations

a Emeritus Senior Research Consultant, Chestnut Health Systems , Punta Gorda , FL.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25052787

Citation

White, William L., et al. "Patterns of Abstinence or Continued Drug Use Among Methadone Maintenance Patients and Their Relation to Treatment Retention." Journal of Psychoactive Drugs, vol. 46, no. 2, 2014, pp. 114-22.
White WL, Campbell MD, Spencer RD, et al. Patterns of abstinence or continued drug use among methadone maintenance patients and their relation to treatment retention. J Psychoactive Drugs. 2014;46(2):114-22.
White, W. L., Campbell, M. D., Spencer, R. D., Hoffman, H. A., Crissman, B., & DuPont, R. L. (2014). Patterns of abstinence or continued drug use among methadone maintenance patients and their relation to treatment retention. Journal of Psychoactive Drugs, 46(2), 114-22. https://doi.org/10.1080/02791072.2014.901587
White WL, et al. Patterns of Abstinence or Continued Drug Use Among Methadone Maintenance Patients and Their Relation to Treatment Retention. J Psychoactive Drugs. 2014 Apr-Jun;46(2):114-22. PubMed PMID: 25052787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of abstinence or continued drug use among methadone maintenance patients and their relation to treatment retention. AU - White,William L, AU - Campbell,Michael D, AU - Spencer,Robert D, AU - Hoffman,Howard A, AU - Crissman,Brian, AU - DuPont,Robert L, PY - 2014/7/24/entrez PY - 2014/7/24/pubmed PY - 2014/8/22/medline KW - benzodiazepines KW - medication-assisted treatment KW - methadone maintenance KW - treatment retention SP - 114 EP - 22 JF - Journal of psychoactive drugs JO - J Psychoactive Drugs VL - 46 IS - 2 N2 - The efficacy and effectiveness of methadone maintenance treatment (MMT) in the medical management of opioid addiction has been well-established, but treatment outcomes are compromised by the continued use of licit and illicit drugs during MMT. The present study examined the relationship between in-treatment illicit drug use and retention and dropout of 604 MMT patients in Washington, D.C. Sixty-eight percent of patients did not test positive for an unprescribed drug during the study period. Of patients who tested positive for an illicit drug during the baseline period, 55% tested positive for cocaine, 44% for opiates, 23% for THC, 20% for benzodiazepines, 7% for PCP, and 4% for amphetamines. Those testing positive were three times more likely to leave treatment than those who did not test positive. Testing positive for one drug doubled the rate of attrition; testing positive for multiple drugs quadrupled the risk of attrition. Non-prescribed opioid or benzodiazepine use was a predictor of MMT dropout, but prescribed opioid or benzodiazepine use was not. Continued illicit drug use poses significant risk for subsequent premature termination of MMT. Assertive clinical management of continued illicit drug use could provide mechanisms to enhance MMT retention and long-term recovery outcomes. SN - 0279-1072 UR - https://www.unboundmedicine.com/medline/citation/25052787/Patterns_of_abstinence_or_continued_drug_use_among_methadone_maintenance_patients_and_their_relation_to_treatment_retention_ L2 - https://www.tandfonline.com/doi/full/10.1080/02791072.2014.901587 DB - PRIME DP - Unbound Medicine ER -