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Rh(III)-catalyzed intramolecular redox-neutral or oxidative cyclization of alkynes: short, efficient synthesis of 3,4-fused indole skeletons.
Org Lett. 2014 Aug 01; 16(15):3900-3.OL

Abstract

A Rh(III)-catalyzed intramolecular redox-neutral or oxidative annulation of a tethered alkyne has been developed to efficiently construct 3,4-fused indoles via a C-H activation pathway. The advantages of this process are (1) ready availability of annulation precursors; (2) broad substrate scope; (3) complete regioselectivity; (4) simple and mild reaction conditions; and (5) no need for an external oxidant or to employ molecular oxygen as the stoichiometric terminal oxidant.

Authors+Show Affiliations

Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Shanghai 201203, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25054410

Citation

Zhou, Bing, et al. "Rh(III)-catalyzed Intramolecular Redox-neutral or Oxidative Cyclization of Alkynes: Short, Efficient Synthesis of 3,4-fused Indole Skeletons." Organic Letters, vol. 16, no. 15, 2014, pp. 3900-3.
Zhou B, Yang Y, Tang H, et al. Rh(III)-catalyzed intramolecular redox-neutral or oxidative cyclization of alkynes: short, efficient synthesis of 3,4-fused indole skeletons. Org Lett. 2014;16(15):3900-3.
Zhou, B., Yang, Y., Tang, H., Du, J., Feng, H., & Li, Y. (2014). Rh(III)-catalyzed intramolecular redox-neutral or oxidative cyclization of alkynes: short, efficient synthesis of 3,4-fused indole skeletons. Organic Letters, 16(15), 3900-3. https://doi.org/10.1021/ol501599j
Zhou B, et al. Rh(III)-catalyzed Intramolecular Redox-neutral or Oxidative Cyclization of Alkynes: Short, Efficient Synthesis of 3,4-fused Indole Skeletons. Org Lett. 2014 Aug 1;16(15):3900-3. PubMed PMID: 25054410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rh(III)-catalyzed intramolecular redox-neutral or oxidative cyclization of alkynes: short, efficient synthesis of 3,4-fused indole skeletons. AU - Zhou,Bing, AU - Yang,Yaxi, AU - Tang,Huanyu, AU - Du,Juanjuan, AU - Feng,Huijin, AU - Li,Yuanchao, Y1 - 2014/07/23/ PY - 2014/7/24/entrez PY - 2014/7/24/pubmed PY - 2014/10/11/medline SP - 3900 EP - 3 JF - Organic letters JO - Org Lett VL - 16 IS - 15 N2 - A Rh(III)-catalyzed intramolecular redox-neutral or oxidative annulation of a tethered alkyne has been developed to efficiently construct 3,4-fused indoles via a C-H activation pathway. The advantages of this process are (1) ready availability of annulation precursors; (2) broad substrate scope; (3) complete regioselectivity; (4) simple and mild reaction conditions; and (5) no need for an external oxidant or to employ molecular oxygen as the stoichiometric terminal oxidant. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/25054410/Rh_III__catalyzed_intramolecular_redox_neutral_or_oxidative_cyclization_of_alkynes:_short_efficient_synthesis_of_34_fused_indole_skeletons_ L2 - https://doi.org/10.1021/ol501599j DB - PRIME DP - Unbound Medicine ER -