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Large Virchow-Robin spaces: MR-clinical correlation.
AJNR Am J Neuroradiol. 1989 Sep-Oct; 10(5):929-36.AA

Abstract

High-field MR scans frequently show Virchow-Robin spaces, which conform to the path of the penetrating arteries as they enter either the basal ganglia or the cortical gray matter over the high convexities. A retrospective review of 816 MR scans was undertaken to determine the clinical significance and associations (if any) of this finding. The Virchow-Robin spaces were graded, as were the nonspecific white-matter lesions. The presence of atrophy, infarction, hydrocephalus, and miscellaneous disease was noted. Large Virchow-Robin spaces were identified in 314 cases. A study sample was created consisting of a positive group containing all the larger grade 2 and 3 Virchow-Robin spaces (67 patients) and a negative or control group of 109 randomly selected patients from the original 502 who did not have large Virchow-Robin spaces. The charts of this study sample were reviewed and the following patient variables were noted: age, gender, incidental white-matter lesions, infarction, dementia, hypertension, and atrophy. For each variable, the proportion of patients who were positive for that variable was calculated for each of the two groups and compared across groups by using a Fisher exact test. Multiple logistic regression analysis was used to determine whether any of these variables were jointly associated with being "positive" or "negative" for large Virchow-Robin spaces. Some variables were strongly associated with being positive for large Virchow-Robin spaces: age, hypertension, dementia, and incidental white-matter lesions. Logistic regression analysis revealed that when all of these variables are considered jointly, only age remains significant.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Radiology, New York Hospital/Cornell Medical Center, NY 10021.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2505536

Citation

Heier, L A., et al. "Large Virchow-Robin Spaces: MR-clinical Correlation." AJNR. American Journal of Neuroradiology, vol. 10, no. 5, 1989, pp. 929-36.
Heier LA, Bauer CJ, Schwartz L, et al. Large Virchow-Robin spaces: MR-clinical correlation. AJNR Am J Neuroradiol. 1989;10(5):929-36.
Heier, L. A., Bauer, C. J., Schwartz, L., Zimmerman, R. D., Morgello, S., & Deck, M. D. (1989). Large Virchow-Robin spaces: MR-clinical correlation. AJNR. American Journal of Neuroradiology, 10(5), 929-36.
Heier LA, et al. Large Virchow-Robin Spaces: MR-clinical Correlation. AJNR Am J Neuroradiol. 1989 Sep-Oct;10(5):929-36. PubMed PMID: 2505536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large Virchow-Robin spaces: MR-clinical correlation. AU - Heier,L A, AU - Bauer,C J, AU - Schwartz,L, AU - Zimmerman,R D, AU - Morgello,S, AU - Deck,M D, PY - 1989/9/1/pubmed PY - 1989/9/1/medline PY - 1989/9/1/entrez SP - 929 EP - 36 JF - AJNR. American journal of neuroradiology JO - AJNR Am J Neuroradiol VL - 10 IS - 5 N2 - High-field MR scans frequently show Virchow-Robin spaces, which conform to the path of the penetrating arteries as they enter either the basal ganglia or the cortical gray matter over the high convexities. A retrospective review of 816 MR scans was undertaken to determine the clinical significance and associations (if any) of this finding. The Virchow-Robin spaces were graded, as were the nonspecific white-matter lesions. The presence of atrophy, infarction, hydrocephalus, and miscellaneous disease was noted. Large Virchow-Robin spaces were identified in 314 cases. A study sample was created consisting of a positive group containing all the larger grade 2 and 3 Virchow-Robin spaces (67 patients) and a negative or control group of 109 randomly selected patients from the original 502 who did not have large Virchow-Robin spaces. The charts of this study sample were reviewed and the following patient variables were noted: age, gender, incidental white-matter lesions, infarction, dementia, hypertension, and atrophy. For each variable, the proportion of patients who were positive for that variable was calculated for each of the two groups and compared across groups by using a Fisher exact test. Multiple logistic regression analysis was used to determine whether any of these variables were jointly associated with being "positive" or "negative" for large Virchow-Robin spaces. Some variables were strongly associated with being positive for large Virchow-Robin spaces: age, hypertension, dementia, and incidental white-matter lesions. Logistic regression analysis revealed that when all of these variables are considered jointly, only age remains significant.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0195-6108 UR - https://www.unboundmedicine.com/medline/citation/2505536/Large_Virchow_Robin_spaces:_MR_clinical_correlation_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -