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Hydrogen sulfide as a potent cardiovascular protective agent.
Clin Chim Acta. 2014 Nov 01; 437:78-87.CC

Abstract

Hydrogen sulfide (H2S) is a well-known toxic gas with the characteristic smell of rotten eggs. It is synthesized endogenously in mammals from the sulfur-containing amino acid l-cysteine by the action of several distinct enzymes: cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) along with cysteine aminotransferase (CAT). In particular, CSE is considered to be the major H2S-producing enzyme in the cardiovascular system. As the third gasotransmitter next to nitric oxide (NO) and carbon monoxide (CO), H2S plays an important role in the regulation of vasodilation, angiogenesis, inflammation, oxidative stress and apoptosis. Growing evidence has demonstrated that this gas exerts a significant protective effect against the progression of cardiovascular diseases by a number of mechanisms such as vasorelaxation, inhibition of cardiovascular remodeling and resistance to form foam cells. The aim of this review is to provide an overview of the physiological functions of H2S and its protection against several major cardiovascular diseases, and to explore its potential health and therapeutic benefits. A better understanding will help develop novel H2S-based therapeutic interventions for these diseases.

Authors+Show Affiliations

Life Science Research Center, University of South China, Hengyang, Hunan 421001, China.Department of Pharmacy, Central Hospital of Hengyang City, Hengyang, Hunan 421000, China.Department of Ophthalmology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada.Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.Department of Orthopedics, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China. Electronic address: 2682446780@qq.com.Life Science Research Center, University of South China, Hengyang, Hunan 421001, China. Electronic address: tangchaoke@qq.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25058799

Citation

Yu, Xiao-Hua, et al. "Hydrogen Sulfide as a Potent Cardiovascular Protective Agent." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 437, 2014, pp. 78-87.
Yu XH, Cui LB, Wu K, et al. Hydrogen sulfide as a potent cardiovascular protective agent. Clin Chim Acta. 2014;437:78-87.
Yu, X. H., Cui, L. B., Wu, K., Zheng, X. L., Cayabyab, F. S., Chen, Z. W., & Tang, C. K. (2014). Hydrogen sulfide as a potent cardiovascular protective agent. Clinica Chimica Acta; International Journal of Clinical Chemistry, 437, 78-87. https://doi.org/10.1016/j.cca.2014.07.012
Yu XH, et al. Hydrogen Sulfide as a Potent Cardiovascular Protective Agent. Clin Chim Acta. 2014 Nov 1;437:78-87. PubMed PMID: 25058799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide as a potent cardiovascular protective agent. AU - Yu,Xiao-Hua, AU - Cui,Li-Bao, AU - Wu,Kai, AU - Zheng,Xi-Long, AU - Cayabyab,Francisco S, AU - Chen,Zhi-Wei, AU - Tang,Chao-Ke, Y1 - 2014/07/21/ PY - 2014/05/03/received PY - 2014/07/07/revised PY - 2014/07/10/accepted PY - 2014/7/25/entrez PY - 2014/7/25/pubmed PY - 2015/5/13/medline KW - Atherosclerosis KW - CHD KW - CSE KW - H(2)S KW - Heart failure SP - 78 EP - 87 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 437 N2 - Hydrogen sulfide (H2S) is a well-known toxic gas with the characteristic smell of rotten eggs. It is synthesized endogenously in mammals from the sulfur-containing amino acid l-cysteine by the action of several distinct enzymes: cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3-MST) along with cysteine aminotransferase (CAT). In particular, CSE is considered to be the major H2S-producing enzyme in the cardiovascular system. As the third gasotransmitter next to nitric oxide (NO) and carbon monoxide (CO), H2S plays an important role in the regulation of vasodilation, angiogenesis, inflammation, oxidative stress and apoptosis. Growing evidence has demonstrated that this gas exerts a significant protective effect against the progression of cardiovascular diseases by a number of mechanisms such as vasorelaxation, inhibition of cardiovascular remodeling and resistance to form foam cells. The aim of this review is to provide an overview of the physiological functions of H2S and its protection against several major cardiovascular diseases, and to explore its potential health and therapeutic benefits. A better understanding will help develop novel H2S-based therapeutic interventions for these diseases. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/25058799/Hydrogen_sulfide_as_a_potent_cardiovascular_protective_agent_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(14)00299-X DB - PRIME DP - Unbound Medicine ER -