Tags

Type your tag names separated by a space and hit enter

Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans.
Neurotoxicology. 2014 Sep; 44:263-9.N

Abstract

BACKGROUND

More than 100,000 US troops were potentially exposed to chemical warfare agents sarin (GB) and cyclosarin (GF) when an ammunition dump at Khamisiyah, Iraq was destroyed during the 1991 Gulf War (GW). We previously reported reduced hippocampal volume in GW veterans with suspected GB/GF exposure relative to matched, unexposed GW veterans estimated from 1.5T magnetic resonance images (MRI). Here we investigate, in a different cohort of GW veterans, whether low-level GB/GF exposure is associated with structural alterations in specific hippocampal subfields, estimated from 4T MRI.

METHODS

The Automatic Segmentation of Hippocampal Subfields (ASHS) technique was used to quantify CA1, CA2, CA3 and dentate gyrus (DG), and subiculum (SUB) subfields volumes from high-resolution T2-weighted images acquired on a 4T MR scanner in 56 GW veterans with suspected GB/GF exposure and 56 "matched" unexposed GW veterans (mean age 49±7 years).

RESULTS

GB/GF exposed veterans had smaller CA2 (p=0.003) and CA3/DG (p=0.01) subfield volumes compared to matched, unexposed GW veterans. There were no group difference in total hippocampal volume, quantified with FreeSurfer, and no dose-response relationship between estimated levels of GB/GF exposure and total hippocampal or subfield volume.

CONCLUSIONS

These findings extend our previous report of structural alterations in the hippocampi of GW veterans with suspected GB/GF exposure to volume changes in the CA2, CA3, and DG hippocampal subfields in a different cohort of GW veterans with suspected GB/GF exposure.

Authors+Show Affiliations

Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, United States; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; Department of Psychiatry, University of California San Francisco, San Francisco, CA, United States. Electronic address: linda.chao@ucsf.edu.Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, United States.Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, United States.Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, United States.Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, United States; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25058901

Citation

Chao, Linda L., et al. "Effects of Low-level Sarin and Cyclosarin Exposure On Hippocampal Subfields in Gulf War Veterans." Neurotoxicology, vol. 44, 2014, pp. 263-9.
Chao LL, Kriger S, Buckley S, et al. Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans. Neurotoxicology. 2014;44:263-9.
Chao, L. L., Kriger, S., Buckley, S., Ng, P., & Mueller, S. G. (2014). Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans. Neurotoxicology, 44, 263-9. https://doi.org/10.1016/j.neuro.2014.07.003
Chao LL, et al. Effects of Low-level Sarin and Cyclosarin Exposure On Hippocampal Subfields in Gulf War Veterans. Neurotoxicology. 2014;44:263-9. PubMed PMID: 25058901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans. AU - Chao,Linda L, AU - Kriger,Stephen, AU - Buckley,Shannon, AU - Ng,Peter, AU - Mueller,Susanne G, Y1 - 2014/07/21/ PY - 2014/04/03/received PY - 2014/07/10/revised PY - 2014/07/11/accepted PY - 2014/7/25/entrez PY - 2014/7/25/pubmed PY - 2015/5/28/medline KW - Cyclosarin KW - Gulf War veterans KW - Hippocampus KW - Magnetic resonance imaging KW - Sarin SP - 263 EP - 9 JF - Neurotoxicology JO - Neurotoxicology VL - 44 N2 - BACKGROUND: More than 100,000 US troops were potentially exposed to chemical warfare agents sarin (GB) and cyclosarin (GF) when an ammunition dump at Khamisiyah, Iraq was destroyed during the 1991 Gulf War (GW). We previously reported reduced hippocampal volume in GW veterans with suspected GB/GF exposure relative to matched, unexposed GW veterans estimated from 1.5T magnetic resonance images (MRI). Here we investigate, in a different cohort of GW veterans, whether low-level GB/GF exposure is associated with structural alterations in specific hippocampal subfields, estimated from 4T MRI. METHODS: The Automatic Segmentation of Hippocampal Subfields (ASHS) technique was used to quantify CA1, CA2, CA3 and dentate gyrus (DG), and subiculum (SUB) subfields volumes from high-resolution T2-weighted images acquired on a 4T MR scanner in 56 GW veterans with suspected GB/GF exposure and 56 "matched" unexposed GW veterans (mean age 49±7 years). RESULTS: GB/GF exposed veterans had smaller CA2 (p=0.003) and CA3/DG (p=0.01) subfield volumes compared to matched, unexposed GW veterans. There were no group difference in total hippocampal volume, quantified with FreeSurfer, and no dose-response relationship between estimated levels of GB/GF exposure and total hippocampal or subfield volume. CONCLUSIONS: These findings extend our previous report of structural alterations in the hippocampi of GW veterans with suspected GB/GF exposure to volume changes in the CA2, CA3, and DG hippocampal subfields in a different cohort of GW veterans with suspected GB/GF exposure. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/25058901/Effects_of_low_level_sarin_and_cyclosarin_exposure_on_hippocampal_subfields_in_Gulf_War_Veterans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(14)00132-6 DB - PRIME DP - Unbound Medicine ER -