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The influence of vascular risk factors on cognitive decline in patients with Alzheimer's disease.
Maturitas 2014; 79(1):96-9M

Abstract

INTRODUCTION

The influence of vascular risk factors (VRFs) on the rate of cognitive decline in patients with established dementia is unclear. This study aims to examine the association between VRFs and the rate of cognitive decline in patients with Alzheimer's disease (AD).

METHODS

Data were obtained from patients visiting a memory clinic between 2004 and 2012. VRFs were determined at baseline and included hypertension, hypercholesterolemia, diabetes mellitus, overweight and smoking. Continuous values of blood pressure, total cholesterol, glucose level and body mass index were also obtained. Mini-Mental State Exam (MMSE) scores were obtained at baseline and during follow-up visits. The association between VRFs and the annual change in MMSE scores was analysed with a multivariable linear mixed model adjusted for age, sex and the aforementioned VRFs.

RESULTS

From 174 patients (mean age 78.3 years), with a follow-up time up to 5.8 years (mean 1.1 year), in total 447 MMSE scores were obtained. The multivariable analyses showed an association between age as well as systolic blood pressure and a decline in annual rates of change in MMSE scores of -0.05 (95% confidence interval (CI): -0.09 to 0.00) and -0.01 (CI: -0.03 to 0.00), respectively. For all other VRFs, including sex, patients did not show a significant difference.

CONCLUSION

This study did not find an association between preventable vascular risk factors and cognitive decline in patients with AD, except for systolic blood pressure. As the association between systolic blood pressure and decline in MMSE was small, clinical relevance may be limited.

Authors+Show Affiliations

Department of Geriatrics, University Medical Center Utrecht, PO Box 85500, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.Department of Geriatrics, University Medical Center Utrecht, PO Box 85500, Utrecht, The Netherlands. Electronic address: h.l.koek@umcutrecht.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25059438

Citation

Blom, Kim, et al. "The Influence of Vascular Risk Factors On Cognitive Decline in Patients With Alzheimer's Disease." Maturitas, vol. 79, no. 1, 2014, pp. 96-9.
Blom K, Vaartjes I, Peters SA, et al. The influence of vascular risk factors on cognitive decline in patients with Alzheimer's disease. Maturitas. 2014;79(1):96-9.
Blom, K., Vaartjes, I., Peters, S. A., & Koek, H. L. (2014). The influence of vascular risk factors on cognitive decline in patients with Alzheimer's disease. Maturitas, 79(1), pp. 96-9. doi:10.1016/j.maturitas.2014.06.017.
Blom K, et al. The Influence of Vascular Risk Factors On Cognitive Decline in Patients With Alzheimer's Disease. Maturitas. 2014;79(1):96-9. PubMed PMID: 25059438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of vascular risk factors on cognitive decline in patients with Alzheimer's disease. AU - Blom,Kim, AU - Vaartjes,Ilonca, AU - Peters,Sanne A E, AU - Koek,Huiberdina L, Y1 - 2014/06/30/ PY - 2014/02/12/received PY - 2014/06/01/revised PY - 2014/06/23/accepted PY - 2014/7/26/entrez PY - 2014/7/26/pubmed PY - 2016/8/17/medline KW - Alzheimer's Disease KW - Diabetes mellitus KW - Hypercholesterolemia KW - Hypertension KW - Overweight KW - Smoking. SP - 96 EP - 9 JF - Maturitas JO - Maturitas VL - 79 IS - 1 N2 - INTRODUCTION: The influence of vascular risk factors (VRFs) on the rate of cognitive decline in patients with established dementia is unclear. This study aims to examine the association between VRFs and the rate of cognitive decline in patients with Alzheimer's disease (AD). METHODS: Data were obtained from patients visiting a memory clinic between 2004 and 2012. VRFs were determined at baseline and included hypertension, hypercholesterolemia, diabetes mellitus, overweight and smoking. Continuous values of blood pressure, total cholesterol, glucose level and body mass index were also obtained. Mini-Mental State Exam (MMSE) scores were obtained at baseline and during follow-up visits. The association between VRFs and the annual change in MMSE scores was analysed with a multivariable linear mixed model adjusted for age, sex and the aforementioned VRFs. RESULTS: From 174 patients (mean age 78.3 years), with a follow-up time up to 5.8 years (mean 1.1 year), in total 447 MMSE scores were obtained. The multivariable analyses showed an association between age as well as systolic blood pressure and a decline in annual rates of change in MMSE scores of -0.05 (95% confidence interval (CI): -0.09 to 0.00) and -0.01 (CI: -0.03 to 0.00), respectively. For all other VRFs, including sex, patients did not show a significant difference. CONCLUSION: This study did not find an association between preventable vascular risk factors and cognitive decline in patients with AD, except for systolic blood pressure. As the association between systolic blood pressure and decline in MMSE was small, clinical relevance may be limited. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/25059438/The_influence_of_vascular_risk_factors_on_cognitive_decline_in_patients_with_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(14)00213-8 DB - PRIME DP - Unbound Medicine ER -