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Meta-analysis of the risk of cataract in type 2 diabetes.

Abstract

BACKGROUND

This meta-analysis aimed to investigate the association between type 2 diabetes (T2D) and the risk of cataract.

METHODS

Databases of Pubmed, Embase, and SpringerLink were retrieved for observational studies published before November 2013. The odds ratio (OR) and 95% confidence interval (CI) were used for estimating the association. All statistical analyses were performed by Stata 10.0 software.

RESULTS

A total of 8 studies involving 20837 subjects were included in the meta-analysis. The risk of any cataract (AC) in T2D patients was higher than that in non-diabetic subjects (OR = 1.97, 95% CI: 1.45-2.67, P < 0.001). The risks of cortical cataract posterior (CC) (OR = 1.68, 95% CI: 1.47-1.91, P < 0.001) and posterior subcapsular (PSC) (OR = 1.55, 95% CI: 1.27-1.90, P < 0.001) were significantly elevated in T2D patients, while no significant association was found in nuclear sclerosis (NS) (OR = 1.36, 95% CI: 0.97-1.90, P = 0.070).

CONCLUSION

T2D patients had a higher risk of cataracts, excepting NS. Special attention should be paid on the ophthalmic extermination, especially for cataract in T2D patients.

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  • Authors+Show Affiliations

    ,

    Department of Ophthalmology, The Affiliated Beijing Children's Hospital of Capital Medical University; National Key Discipline of Pediatrics, Ministry of Education, Beijing 100045, China. lliilili2@hotmail.com.

    ,

    Source

    BMC ophthalmology 14: 2014 Jul 24 pg 94

    MeSH

    Aging
    Cataract
    Diabetes Mellitus, Type 2
    Global Health
    Humans
    Incidence
    Odds Ratio
    Prevalence
    Risk Assessment
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review

    Language

    eng

    PubMed ID

    25060855

    Citation

    Li, Li, et al. "Meta-analysis of the Risk of Cataract in Type 2 Diabetes." BMC Ophthalmology, vol. 14, 2014, p. 94.
    Li L, Wan XH, Zhao GH. Meta-analysis of the risk of cataract in type 2 diabetes. BMC Ophthalmol. 2014;14:94.
    Li, L., Wan, X. H., & Zhao, G. H. (2014). Meta-analysis of the risk of cataract in type 2 diabetes. BMC Ophthalmology, 14, p. 94. doi:10.1186/1471-2415-14-94.
    Li L, Wan XH, Zhao GH. Meta-analysis of the Risk of Cataract in Type 2 Diabetes. BMC Ophthalmol. 2014 Jul 24;14:94. PubMed PMID: 25060855.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Meta-analysis of the risk of cataract in type 2 diabetes. AU - Li,Li, AU - Wan,Xiu-hua, AU - Zhao,Guo-hong, Y1 - 2014/07/24/ PY - 2014/05/15/received PY - 2014/07/15/accepted PY - 2014/7/26/entrez PY - 2014/7/26/pubmed PY - 2015/1/30/medline SP - 94 EP - 94 JF - BMC ophthalmology JO - BMC Ophthalmol VL - 14 N2 - BACKGROUND: This meta-analysis aimed to investigate the association between type 2 diabetes (T2D) and the risk of cataract. METHODS: Databases of Pubmed, Embase, and SpringerLink were retrieved for observational studies published before November 2013. The odds ratio (OR) and 95% confidence interval (CI) were used for estimating the association. All statistical analyses were performed by Stata 10.0 software. RESULTS: A total of 8 studies involving 20837 subjects were included in the meta-analysis. The risk of any cataract (AC) in T2D patients was higher than that in non-diabetic subjects (OR = 1.97, 95% CI: 1.45-2.67, P < 0.001). The risks of cortical cataract posterior (CC) (OR = 1.68, 95% CI: 1.47-1.91, P < 0.001) and posterior subcapsular (PSC) (OR = 1.55, 95% CI: 1.27-1.90, P < 0.001) were significantly elevated in T2D patients, while no significant association was found in nuclear sclerosis (NS) (OR = 1.36, 95% CI: 0.97-1.90, P = 0.070). CONCLUSION: T2D patients had a higher risk of cataracts, excepting NS. Special attention should be paid on the ophthalmic extermination, especially for cataract in T2D patients. SN - 1471-2415 UR - https://www.unboundmedicine.com/medline/citation/25060855/full_citation L2 - https://bmcophthalmol.biomedcentral.com/articles/10.1186/1471-2415-14-94 DB - PRIME DP - Unbound Medicine ER -