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Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone.
Schizophr Res Treatment 2014; 2014:602390SR

Abstract

Background.

Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries of Aronia melanocarpa (Aronox) on the plasma lipid peroxidation induced by ziprasidone in vitro. Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml).

Results.

We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation: P = 7.0 × 10(-4), P = 1.6 × 10(-3), and P = 2.7 × 10(-3), resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased: P = 6.5 × 10(-8), P = 7.0 × 10(-6), and P = 3.0 × 10(-5), respectively.

Conclusion.

Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone.

Authors+Show Affiliations

Department of Biological Psychiatry, The Chair of Experimental and Clinical Physiology, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215 Lodz, Poland.Department of Biological Psychiatry, The Chair of Experimental and Clinical Physiology, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215 Lodz, Poland.Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25061527

Citation

Dietrich-Muszalska, Anna, et al. "Polyphenols From Berries of Aronia Melanocarpa Reduce the Plasma Lipid Peroxidation Induced By Ziprasidone." Schizophrenia Research and Treatment, vol. 2014, 2014, p. 602390.
Dietrich-Muszalska A, Kopka J, Kontek B. Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone. Schizophr Res Treatment. 2014;2014:602390.
Dietrich-Muszalska, A., Kopka, J., & Kontek, B. (2014). Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone. Schizophrenia Research and Treatment, 2014, p. 602390. doi:10.1155/2014/602390.
Dietrich-Muszalska A, Kopka J, Kontek B. Polyphenols From Berries of Aronia Melanocarpa Reduce the Plasma Lipid Peroxidation Induced By Ziprasidone. Schizophr Res Treatment. 2014;2014:602390. PubMed PMID: 25061527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone. AU - Dietrich-Muszalska,Anna, AU - Kopka,Justyna, AU - Kontek,Bogdan, Y1 - 2014/06/25/ PY - 2014/03/23/received PY - 2014/05/21/revised PY - 2014/05/26/accepted PY - 2014/7/26/entrez PY - 2014/7/26/pubmed PY - 2014/7/26/medline SP - 602390 EP - 602390 JF - Schizophrenia research and treatment JO - Schizophr Res Treatment VL - 2014 N2 - Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries of Aronia melanocarpa (Aronox) on the plasma lipid peroxidation induced by ziprasidone in vitro. Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml). Results. We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation: P = 7.0 × 10(-4), P = 1.6 × 10(-3), and P = 2.7 × 10(-3), resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased: P = 6.5 × 10(-8), P = 7.0 × 10(-6), and P = 3.0 × 10(-5), respectively. Conclusion. Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone. SN - 2090-2085 UR - https://www.unboundmedicine.com/medline/citation/25061527/full_citation L2 - https://dx.doi.org/10.1155/2014/602390 DB - PRIME DP - Unbound Medicine ER -