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Prenatal exposure to phenols and growth in boys.
Epidemiology. 2014 Sep; 25(5):625-35.E

Abstract

BACKGROUND

Phenols interact with nuclear receptors implicated in growth and adipogenesis regulation. Only a few studies have explored their effects on growth in humans.

OBJECTIVES

We studied the associations of maternal exposure to phenols during pregnancy with prenatal and postnatal growth of male newborns.

METHODS

Within a cohort of women recruited during pregnancy, we selected 520 mother-son pairs and quantified 9 phenols in spot urine samples collected during pregnancy. We used ultrasonography during pregnancy, together with birth measurements, to assess fetal growth. We modeled individual postnatal growth trajectories from repeated measures of weight and height in the first 3 years of life.

RESULTS

Triclosan concentration was negatively associated with growth parameters measured at the third ultrasound examination but not earlier in pregnancy. At birth, this phenol tended to be negatively associated with head circumference (-1.2 mm for an interquartile range [IQR] increase in ln-transformed triclosan concentration [95% confidence interval = -2.6 to 0.3]) but not with weight or height. Parabens were positively associated with weight at birth. This positive association remained for 3 years for methylparaben (β = 193 g [-4 to 389]) for an IQR increase in ln-transformed concentrations.

CONCLUSION

We relied on only 1 spot urine sample to assess exposure; because of the high variability in phenol urinary concentrations reported during pregnancy, using only 1 sample may result in exposure misclassification, in particular for bisphenol A. Our study suggested associations between prenatal exposure to parabens and triclosan and prenatal or early postnatal growth.

Authors+Show Affiliations

From the aInserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; bUniversity of Grenoble Alpes, IAB, Grenoble, France; cInserm, Center for research in Epidemiology and Population Health, U1018, Team Epidemiology of Diabetes, Obesity and Renal Disease: Lifelong Approach, Villejuif, France; dUniversité Paris-Sud, Faculty of Pharmacy, Châtenay-Malabry, France; and eCenters for Disease Control and Prevention, Atlanta, GA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25061923

Citation

Philippat, Claire, et al. "Prenatal Exposure to Phenols and Growth in Boys." Epidemiology (Cambridge, Mass.), vol. 25, no. 5, 2014, pp. 625-35.
Philippat C, Botton J, Calafat AM, et al. Prenatal exposure to phenols and growth in boys. Epidemiology. 2014;25(5):625-35.
Philippat, C., Botton, J., Calafat, A. M., Ye, X., Charles, M. A., & Slama, R. (2014). Prenatal exposure to phenols and growth in boys. Epidemiology (Cambridge, Mass.), 25(5), 625-35. https://doi.org/10.1097/EDE.0000000000000132
Philippat C, et al. Prenatal Exposure to Phenols and Growth in Boys. Epidemiology. 2014;25(5):625-35. PubMed PMID: 25061923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to phenols and growth in boys. AU - Philippat,Claire, AU - Botton,Jérémie, AU - Calafat,Antonia M, AU - Ye,Xiaoyun, AU - Charles,Marie-Aline, AU - Slama,Rémy, AU - ,, PY - 2014/7/26/entrez PY - 2014/7/26/pubmed PY - 2015/4/24/medline SP - 625 EP - 35 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 25 IS - 5 N2 - BACKGROUND: Phenols interact with nuclear receptors implicated in growth and adipogenesis regulation. Only a few studies have explored their effects on growth in humans. OBJECTIVES: We studied the associations of maternal exposure to phenols during pregnancy with prenatal and postnatal growth of male newborns. METHODS: Within a cohort of women recruited during pregnancy, we selected 520 mother-son pairs and quantified 9 phenols in spot urine samples collected during pregnancy. We used ultrasonography during pregnancy, together with birth measurements, to assess fetal growth. We modeled individual postnatal growth trajectories from repeated measures of weight and height in the first 3 years of life. RESULTS: Triclosan concentration was negatively associated with growth parameters measured at the third ultrasound examination but not earlier in pregnancy. At birth, this phenol tended to be negatively associated with head circumference (-1.2 mm for an interquartile range [IQR] increase in ln-transformed triclosan concentration [95% confidence interval = -2.6 to 0.3]) but not with weight or height. Parabens were positively associated with weight at birth. This positive association remained for 3 years for methylparaben (β = 193 g [-4 to 389]) for an IQR increase in ln-transformed concentrations. CONCLUSION: We relied on only 1 spot urine sample to assess exposure; because of the high variability in phenol urinary concentrations reported during pregnancy, using only 1 sample may result in exposure misclassification, in particular for bisphenol A. Our study suggested associations between prenatal exposure to parabens and triclosan and prenatal or early postnatal growth. SN - 1531-5487 UR - https://www.unboundmedicine.com/medline/citation/25061923/Prenatal_exposure_to_phenols_and_growth_in_boys_ L2 - https://doi.org/10.1097/EDE.0000000000000132 DB - PRIME DP - Unbound Medicine ER -