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Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10.
J Huntingtons Dis. 2012; 1(1):65-9.JH

Abstract

We analyzed plasma 8OHdG concentrations in 20 individuals enrolled in the Pre-2CARE study before and after treatment with CoQ. Treatment resulted in a mean reduction in 8OHdG of 2.9 ± 2.9 pg/ml for the cohort (p = 0.0003) and 3.0 ± 2.6 pg/ml, for the HD group (p = 0.002). Baseline 8OHdG levels were not different between individuals with HD and controls (19.3 ± 3.2 pg/ml vs. 19.5 ± 4.7 pg/ml, p = 0.87) though baseline CoQ levels were elevated in HD compared with controls (p < 0.001). CoQ treatment reduces plasma 8OHdG and this reduction may serve as a marker of pharmacologic activity of CoQ in HD.

Authors+Show Affiliations

Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA. Kevin_biglan@urmc.rochester.eduDepartment of Neurology, University of Rochester Medical Center, Rochester, NY, USA Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.Departments of Psychiatry, Neurology, Neuroscience and Pharmacology, Johns Hopkins University, Baltimore, MD, USA.Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA Department of Neurology, Georgetown University, Washington, D.C., USA.Boston University School of Medicine, Boston, MA, USA.Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25063191

Citation

Biglan, K M., et al. "Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated With Coenzyme Q10." Journal of Huntington's Disease, vol. 1, no. 1, 2012, pp. 65-9.
Biglan KM, Dorsey ER, Evans RV, et al. Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10. J Huntingtons Dis. 2012;1(1):65-9.
Biglan, K. M., Dorsey, E. R., Evans, R. V., Ross, C. A., Hersch, S., Shoulson, I., Matson, W., & Kieburtz, K. (2012). Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10. Journal of Huntington's Disease, 1(1), 65-9. https://doi.org/10.3233/JHD-2012-120007
Biglan KM, et al. Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated With Coenzyme Q10. J Huntingtons Dis. 2012;1(1):65-9. PubMed PMID: 25063191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma 8-hydroxy-2'-deoxyguanosine Levels in Huntington Disease and Healthy Controls Treated with Coenzyme Q10. AU - Biglan,K M, AU - Dorsey,E R, AU - Evans,R V V, AU - Ross,C A, AU - Hersch,S, AU - Shoulson,I, AU - Matson,W, AU - Kieburtz,K, AU - ,, PY - 2014/7/27/entrez PY - 2012/1/1/pubmed PY - 2016/5/14/medline KW - 8OHdG KW - Huntington disease KW - coenzyme Q10 KW - oxidative injury SP - 65 EP - 9 JF - Journal of Huntington's disease JO - J Huntingtons Dis VL - 1 IS - 1 N2 - We analyzed plasma 8OHdG concentrations in 20 individuals enrolled in the Pre-2CARE study before and after treatment with CoQ. Treatment resulted in a mean reduction in 8OHdG of 2.9 ± 2.9 pg/ml for the cohort (p = 0.0003) and 3.0 ± 2.6 pg/ml, for the HD group (p = 0.002). Baseline 8OHdG levels were not different between individuals with HD and controls (19.3 ± 3.2 pg/ml vs. 19.5 ± 4.7 pg/ml, p = 0.87) though baseline CoQ levels were elevated in HD compared with controls (p < 0.001). CoQ treatment reduces plasma 8OHdG and this reduction may serve as a marker of pharmacologic activity of CoQ in HD. SN - 1879-6400 UR - https://www.unboundmedicine.com/medline/citation/25063191/Plasma_8_hydroxy_2'_deoxyguanosine_Levels_in_Huntington_Disease_and_Healthy_Controls_Treated_with_Coenzyme_Q10_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JHD-2012-120007 DB - PRIME DP - Unbound Medicine ER -