Tags

Type your tag names separated by a space and hit enter

Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD.
J Trace Elem Med Biol 2014; 28(4):482-5JT

Abstract

Alzheimer's disease (AD) is the most common form of dementia. A myriad of complex factors contribute to AD, promoting the deposition in plaques of amyloid-beta (Aβ), which is the main constituent of this pathognomonic sign of AD at autopsy brain inspection. Aβ toxicity is related to oxidative stress, which results in synaptic loss in specific brain areas, eventually leading to cognitive decline. Metal, and especially copper, dyshomeostasis is a key factor in these processes. Recent studies have demonstrated that the serum fraction of copper that is not bound to ceruloplasmin (Non-Cp copper, also known as 'free' or labile copper) increases in a percentage of AD patients and mild cognitive impairment (MCI) subjects; this is considered a precursor of AD. Non-Cp copper is the exchangeable fraction of low molecular weight copper in serum. It is distinguished from the copper structurally bound to the ceruloplasmin protein, a master protein of iron metabolism. Non-Cp copper levels are higher than normal reference values (range 0-1.6μmol/L) in about 50% of amnestic MCI subjects and 60% of AD patients, typifying them in a subset of AD. Meta-analyses, genetic studies and a prognostic study evaluating the predictive value of Non-Cp copper in MCI conversion to full AD demonstrate the existence of this copper phenotype of AD.

Authors+Show Affiliations

Fatebenefratelli Foundation for Health Research and Education, AFaR Division, "San Giovanni Calibita" Fatebenefratelli Hospital, Rome, Italy; Laboratorio di Neurodegenerazione, IRCCS San Raffaele Pisana, Italy. Electronic address: rosanna.squitti@afar.it.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25066791

Citation

Squitti, Rosanna. "Copper Subtype of Alzheimer's Disease (AD): Meta-analyses, Genetic Studies and Predictive Value of Non-ceruloplasmim Copper in Mild Cognitive Impairment Conversion to Full AD." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 28, no. 4, 2014, pp. 482-5.
Squitti R. Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD. J Trace Elem Med Biol. 2014;28(4):482-5.
Squitti, R. (2014). Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 28(4), pp. 482-5. doi:10.1016/j.jtemb.2014.06.018.
Squitti R. Copper Subtype of Alzheimer's Disease (AD): Meta-analyses, Genetic Studies and Predictive Value of Non-ceruloplasmim Copper in Mild Cognitive Impairment Conversion to Full AD. J Trace Elem Med Biol. 2014;28(4):482-5. PubMed PMID: 25066791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD. A1 - Squitti,Rosanna, Y1 - 2014/07/10/ PY - 2014/7/29/entrez PY - 2014/7/30/pubmed PY - 2015/8/20/medline KW - ATP7B KW - Alzheimer's disease KW - Ceruloplasmin KW - Copper KW - Non-Cp copper SP - 482 EP - 5 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 28 IS - 4 N2 - Alzheimer's disease (AD) is the most common form of dementia. A myriad of complex factors contribute to AD, promoting the deposition in plaques of amyloid-beta (Aβ), which is the main constituent of this pathognomonic sign of AD at autopsy brain inspection. Aβ toxicity is related to oxidative stress, which results in synaptic loss in specific brain areas, eventually leading to cognitive decline. Metal, and especially copper, dyshomeostasis is a key factor in these processes. Recent studies have demonstrated that the serum fraction of copper that is not bound to ceruloplasmin (Non-Cp copper, also known as 'free' or labile copper) increases in a percentage of AD patients and mild cognitive impairment (MCI) subjects; this is considered a precursor of AD. Non-Cp copper is the exchangeable fraction of low molecular weight copper in serum. It is distinguished from the copper structurally bound to the ceruloplasmin protein, a master protein of iron metabolism. Non-Cp copper levels are higher than normal reference values (range 0-1.6μmol/L) in about 50% of amnestic MCI subjects and 60% of AD patients, typifying them in a subset of AD. Meta-analyses, genetic studies and a prognostic study evaluating the predictive value of Non-Cp copper in MCI conversion to full AD demonstrate the existence of this copper phenotype of AD. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/25066791/Copper_subtype_of_Alzheimer's_disease__AD_:_meta_analyses_genetic_studies_and_predictive_value_of_non_ceruloplasmim_copper_in_mild_cognitive_impairment_conversion_to_full_AD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(14)00123-0 DB - PRIME DP - Unbound Medicine ER -