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[A study of the antiherpetic activity of the chaga mushroom (Inonotus obliquus) extracts in the Vero cells infected with the herpes simplex virus].
Vopr Virusol. 2014 Mar-Apr; 59(2):45-8.VV

Abstract

The chaga mushroom (Inonotus obliquus) contains a wide range of excellent bioactive compounds. However, limited information exists on the antiviral activity of the compounds extracted from chaga. A number of subfractions of chaga were obtained using different solvents and different procedures. The subfractions of chaga extracted with water, alcohol, alkali were tested for their toxicity for the Vero cell culture and antiviral effect in the Vero cells infected with the Herpes simplex virus (HSV), Type 1. It was shown that most of the subfractions were not toxic for the Vero cells and had protective effect on the Vero cells infected with HSV. The subfraction IV in the concentration 5 microg/ml protected the Vero cells from cytodestructive action of HSV and no viral DNA was detected in infected cells treated with chaga extracts. Best protective effect was observed when compound was added before or within one hour after the Vero cells were infected with HSV.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

rus

PubMed ID

25069286

Citation

Polkovnikova, M V., et al. "[A Study of the Antiherpetic Activity of the Chaga Mushroom (Inonotus Obliquus) Extracts in the Vero Cells Infected With the Herpes Simplex Virus]." Voprosy Virusologii, vol. 59, no. 2, 2014, pp. 45-8.
Polkovnikova MV, Nosik NN, Garaev TM, et al. [A study of the antiherpetic activity of the chaga mushroom (Inonotus obliquus) extracts in the Vero cells infected with the herpes simplex virus]. Vopr Virusol. 2014;59(2):45-8.
Polkovnikova, M. V., Nosik, N. N., Garaev, T. M., Kondrashina, N. G., Finogenova, M. P., & Shibnev, V. A. (2014). [A study of the antiherpetic activity of the chaga mushroom (Inonotus obliquus) extracts in the Vero cells infected with the herpes simplex virus]. Voprosy Virusologii, 59(2), 45-8.
Polkovnikova MV, et al. [A Study of the Antiherpetic Activity of the Chaga Mushroom (Inonotus Obliquus) Extracts in the Vero Cells Infected With the Herpes Simplex Virus]. Vopr Virusol. 2014 Mar-Apr;59(2):45-8. PubMed PMID: 25069286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A study of the antiherpetic activity of the chaga mushroom (Inonotus obliquus) extracts in the Vero cells infected with the herpes simplex virus]. AU - Polkovnikova,M V, AU - Nosik,N N, AU - Garaev,T M, AU - Kondrashina,N G, AU - Finogenova,M P, AU - Shibnev,V A, PY - 2014/7/30/entrez PY - 2014/7/30/pubmed PY - 2014/9/5/medline SP - 45 EP - 8 JF - Voprosy virusologii JO - Vopr Virusol VL - 59 IS - 2 N2 - The chaga mushroom (Inonotus obliquus) contains a wide range of excellent bioactive compounds. However, limited information exists on the antiviral activity of the compounds extracted from chaga. A number of subfractions of chaga were obtained using different solvents and different procedures. The subfractions of chaga extracted with water, alcohol, alkali were tested for their toxicity for the Vero cell culture and antiviral effect in the Vero cells infected with the Herpes simplex virus (HSV), Type 1. It was shown that most of the subfractions were not toxic for the Vero cells and had protective effect on the Vero cells infected with HSV. The subfraction IV in the concentration 5 microg/ml protected the Vero cells from cytodestructive action of HSV and no viral DNA was detected in infected cells treated with chaga extracts. Best protective effect was observed when compound was added before or within one hour after the Vero cells were infected with HSV. SN - 0507-4088 UR - https://www.unboundmedicine.com/medline/citation/25069286/[A_study_of_the_antiherpetic_activity_of_the_chaga_mushroom_(Inonotus_obliquus)_extracts_in_the_Vero_cells_infected_with_the_herpes_simplex_virus]. DB - PRIME DP - Unbound Medicine ER -