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Lethal Encephalitozoon cuniculi genotype III infection in Steppe lemmings (Lagurus lagurus).
Vet Parasitol. 2014 Sep 15; 205(1-2):357-60.VP

Abstract

Microsporidia are ubiquitous, spore-forming, intracellular parasites infecting invertebrates and vertebrates. Some of them are important opportunistic pathogens in humans, including three species of genus Encephalitozoon. Intraspecies genetic variation with a different range of hosts is known in Encephalitozoon cuniculi distinguishing four genotypes. Recently, E. cuniculi is often observed in pet animals, mainly E. cuniculi genotype I in pet rabbits. This study described a fatal encephalitozoonosis in a group of pet rodents Steppe lemmings (Lagurus lagurus). The animals were presented with progressive weight loss, aggression, cannibalism, purulent conjunctivitis and hind limb paresis. Death occurred within 48 h after the onset of clinical signs. The group comprised of 15 animals was affected and died within a period of three months. Post-mortal examination did not show any macroscopic changes. Microsporidial vacuoles with typical spores were found in brain and kidney tissues and E. cuniculi DNA in all tested organs. The internal transcribed spacer region (ITS) of rRNA gene showed 100% homology with E. cuniculi genotype III previously identified in dogs, tamarin colonies from zoos, swine, birds and humans. Pet lemmings could represent a new potential source of the infection for their breeders.

Authors+Show Affiliations

Department of Pathological Morphology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, 612 42 Brno, Czech Republic; Central European Institute of Technology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, 612 42 Brno, Czech Republic.Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, v.v.i., Branišovská 31, 370 05 České Budějovice, Czech Republic.Avian & Exotic Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, 612 42 Brno, Czech Republic.Avian & Exotic Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, 612 42 Brno, Czech Republic.Department of Pathological Morphology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, 612 42 Brno, Czech Republic.Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, v.v.i., Branišovská 31, 370 05 České Budějovice, Czech Republic; Faculty of Agriculture, University of South Bohemia in České Budějovice, Branišovská 31, 370 05 České Budějovice, Czech Republic. Electronic address: kvac@paru.cas.cz.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25073415

Citation

Hofmannová, Lada, et al. "Lethal Encephalitozoon Cuniculi Genotype III Infection in Steppe Lemmings (Lagurus Lagurus)." Veterinary Parasitology, vol. 205, no. 1-2, 2014, pp. 357-60.
Hofmannová L, Sak B, Jekl V, et al. Lethal Encephalitozoon cuniculi genotype III infection in Steppe lemmings (Lagurus lagurus). Vet Parasitol. 2014;205(1-2):357-60.
Hofmannová, L., Sak, B., Jekl, V., Mináriková, A., Skorič, M., & Kváč, M. (2014). Lethal Encephalitozoon cuniculi genotype III infection in Steppe lemmings (Lagurus lagurus). Veterinary Parasitology, 205(1-2), 357-60. https://doi.org/10.1016/j.vetpar.2014.07.008
Hofmannová L, et al. Lethal Encephalitozoon Cuniculi Genotype III Infection in Steppe Lemmings (Lagurus Lagurus). Vet Parasitol. 2014 Sep 15;205(1-2):357-60. PubMed PMID: 25073415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lethal Encephalitozoon cuniculi genotype III infection in Steppe lemmings (Lagurus lagurus). AU - Hofmannová,Lada, AU - Sak,Bohumil, AU - Jekl,Vladimír, AU - Mináriková,Andrea, AU - Skorič,Miša, AU - Kváč,Martin, Y1 - 2014/07/15/ PY - 2014/04/23/received PY - 2014/07/03/revised PY - 2014/07/06/accepted PY - 2014/7/31/entrez PY - 2014/7/31/pubmed PY - 2017/4/14/medline KW - Encephalitozoon cuniculi genotype III KW - Histology KW - Lethal infection KW - PCR KW - Steppe lemmings SP - 357 EP - 60 JF - Veterinary parasitology JO - Vet. Parasitol. VL - 205 IS - 1-2 N2 - Microsporidia are ubiquitous, spore-forming, intracellular parasites infecting invertebrates and vertebrates. Some of them are important opportunistic pathogens in humans, including three species of genus Encephalitozoon. Intraspecies genetic variation with a different range of hosts is known in Encephalitozoon cuniculi distinguishing four genotypes. Recently, E. cuniculi is often observed in pet animals, mainly E. cuniculi genotype I in pet rabbits. This study described a fatal encephalitozoonosis in a group of pet rodents Steppe lemmings (Lagurus lagurus). The animals were presented with progressive weight loss, aggression, cannibalism, purulent conjunctivitis and hind limb paresis. Death occurred within 48 h after the onset of clinical signs. The group comprised of 15 animals was affected and died within a period of three months. Post-mortal examination did not show any macroscopic changes. Microsporidial vacuoles with typical spores were found in brain and kidney tissues and E. cuniculi DNA in all tested organs. The internal transcribed spacer region (ITS) of rRNA gene showed 100% homology with E. cuniculi genotype III previously identified in dogs, tamarin colonies from zoos, swine, birds and humans. Pet lemmings could represent a new potential source of the infection for their breeders. SN - 1873-2550 UR - https://www.unboundmedicine.com/medline/citation/25073415/Lethal_Encephalitozoon_cuniculi_genotype_III_infection_in_Steppe_lemmings__Lagurus_lagurus__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(14)00395-1 DB - PRIME DP - Unbound Medicine ER -