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Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales.
BMC Evol Biol 2014; 14:167BE

Abstract

BACKGROUND

Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens.

RESULTS

Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence.

CONCLUSIONS

Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDepartment of Zoonoses, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping Liuzi 5, Beijing 102206, China. zhangyongzhen@icdc.cn.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25073875

Citation

Kang, Yan-Jun, et al. "Extensive Diversity of Rickettsiales Bacteria in Two Species of Ticks From China and the Evolution of the Rickettsiales." BMC Evolutionary Biology, vol. 14, 2014, p. 167.
Kang YJ, Diao XN, Zhao GY, et al. Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales. BMC Evol Biol. 2014;14:167.
Kang, Y. J., Diao, X. N., Zhao, G. Y., Chen, M. H., Xiong, Y., Shi, M., ... Zhang, Y. Z. (2014). Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales. BMC Evolutionary Biology, 14, p. 167. doi:10.1186/s12862-014-0167-2.
Kang YJ, et al. Extensive Diversity of Rickettsiales Bacteria in Two Species of Ticks From China and the Evolution of the Rickettsiales. BMC Evol Biol. 2014 Jul 30;14:167. PubMed PMID: 25073875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales. AU - Kang,Yan-Jun, AU - Diao,Xiu-Nian, AU - Zhao,Gao-Yu, AU - Chen,Ming-Hui, AU - Xiong,Yanwen, AU - Shi,Mang, AU - Fu,Wei-Ming, AU - Guo,Yu-Jiang, AU - Pan,Bao, AU - Chen,Xiao-Ping, AU - Holmes,Edward C, AU - Gillespie,Joseph J, AU - Dumler,Stephen J, AU - Zhang,Yong-Zhen, Y1 - 2014/07/30/ PY - 2014/05/31/received PY - 2014/07/21/accepted PY - 2014/7/31/entrez PY - 2014/7/31/pubmed PY - 2014/10/16/medline SP - 167 EP - 167 JF - BMC evolutionary biology JO - BMC Evol. Biol. VL - 14 N2 - BACKGROUND: Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic lineage. Several rickettsial genera harbor species that are significant emerging and re-emerging pathogens of humans. As species of Rickettsiales are associated with an extremely diverse host range, a better understanding of the historical associations between these bacteria and their hosts will provide important information on their evolutionary trajectories and, particularly, their potential emergence as pathogens. RESULTS: Nine species of Rickettsiales (two in the genus Rickettsia, three in the genus Anaplasma, and four in the genus Ehrlichia) were identified in two species of hard ticks (Dermacentor nuttalli and Hyalomma asiaticum) from two geographic regions in Xinjiang through genetic analyses of 16S rRNA, gltA, and groEL gene sequences. Notably, two lineages of Ehrlichia and one lineage of Anaplasma were distinct from any known Rickettsiales, suggesting the presence of potentially novel species in ticks in Xinjiang. Our phylogenetic analyses revealed some topological differences between the phylogenies of the bacteria and their vectors, which led us to marginally reject a model of exclusive bacteria-vector co-divergence. CONCLUSIONS: Ticks are an important natural reservoir of many diverse species of Rickettsiales. In this work, we identified a single tick species that harbors multiple species of Rickettsiales, and uncovered extensive genetic diversity of these bacteria in two tick species from Xinjiang. Both bacteria-vector co-divergence and cross-species transmission appear to have played important roles in Rickettsiales evolution. SN - 1471-2148 UR - https://www.unboundmedicine.com/medline/citation/25073875/Extensive_diversity_of_Rickettsiales_bacteria_in_two_species_of_ticks_from_China_and_the_evolution_of_the_Rickettsiales_ L2 - https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-014-0167-2 DB - PRIME DP - Unbound Medicine ER -