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A comparison of multiphasic oral contraceptives containing norgestimate or desogestrel in acne treatment: a randomized trial.
Contraception. 2014 Nov; 90(5):535-41.C

Abstract

OBJECTIVE

This study aimed to compare the effectiveness and safety of triphasic combined oral contraceptives (OCs) containing ethinyl estradiol (EE) and norgestimate (NGM) and biphasic combined OCs containing EE and desogestrel (DSG) in the treatment of mild to moderate acne.

STUDY DESIGN

This was an investigator-blinded, randomized, parallel group trial conducted at 3 centers in Thailand. Female subjects 18-45 years old were assigned to one or the other OCs and evaluated for efficacy and safety parameters at the baseline visit and after 1, 3 and 6 months of treatment.

RESULTS

Among 201 randomized subjects, data from 93 subjects in the EE/NGM group and 95 subjects in the EE/DSG group were analyzed. After 6 months of treatment with EE/NGM and EE/DSG, no differences between formulations were found for the decrease in total acne lesion counts (74.4% vs. 65.1%, respectively, p=.070) or facial improvement score. More women using EE/NGM showed a decrease in severity of facial seborrhea than those using EE/DSG (p=.005). No changes in weight were noted in either group as compared to baseline.

CONCLUSION

Multiphasic OCs containing EE/NGM and EE/DSG provided comparable efficacy and tolerability in the treatment of acne. However, EE/NGM had a more beneficial effect on facial seborrhea reduction than EE/DSG.

IMPLICATIONS

EE/NGM and EE/DSG are multiphasic OCs, which were shown to be clinically equally effective for mild to moderate facial acne, and the multiphasic combined OC with NGM was more effective for women with facial seborrhea. Clinicians may apply the results of this study when considering treatment options for facial acne and seborrhea.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address: Unnop.J@Chula.ac.th.Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.Medical Affairs, Janssen-Cilag, Bangkok, Thailand.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25074072

Citation

Jaisamrarn, Unnop, et al. "A Comparison of Multiphasic Oral Contraceptives Containing Norgestimate or Desogestrel in Acne Treatment: a Randomized Trial." Contraception, vol. 90, no. 5, 2014, pp. 535-41.
Jaisamrarn U, Chaovisitsaree S, Angsuwathana S, et al. A comparison of multiphasic oral contraceptives containing norgestimate or desogestrel in acne treatment: a randomized trial. Contraception. 2014;90(5):535-41.
Jaisamrarn, U., Chaovisitsaree, S., Angsuwathana, S., & Nerapusee, O. (2014). A comparison of multiphasic oral contraceptives containing norgestimate or desogestrel in acne treatment: a randomized trial. Contraception, 90(5), 535-41. https://doi.org/10.1016/j.contraception.2014.06.002
Jaisamrarn U, et al. A Comparison of Multiphasic Oral Contraceptives Containing Norgestimate or Desogestrel in Acne Treatment: a Randomized Trial. Contraception. 2014;90(5):535-41. PubMed PMID: 25074072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of multiphasic oral contraceptives containing norgestimate or desogestrel in acne treatment: a randomized trial. AU - Jaisamrarn,Unnop, AU - Chaovisitsaree,Somsak, AU - Angsuwathana,Surasak, AU - Nerapusee,Osot, Y1 - 2014/06/12/ PY - 2013/12/31/received PY - 2014/05/28/revised PY - 2014/06/05/accepted PY - 2014/7/31/entrez PY - 2014/7/31/pubmed PY - 2015/6/13/medline KW - Acne lesion KW - Biphasic oral contraceptive KW - Facial seborrhea KW - Triphasic oral contraceptive SP - 535 EP - 41 JF - Contraception JO - Contraception VL - 90 IS - 5 N2 - OBJECTIVE: This study aimed to compare the effectiveness and safety of triphasic combined oral contraceptives (OCs) containing ethinyl estradiol (EE) and norgestimate (NGM) and biphasic combined OCs containing EE and desogestrel (DSG) in the treatment of mild to moderate acne. STUDY DESIGN: This was an investigator-blinded, randomized, parallel group trial conducted at 3 centers in Thailand. Female subjects 18-45 years old were assigned to one or the other OCs and evaluated for efficacy and safety parameters at the baseline visit and after 1, 3 and 6 months of treatment. RESULTS: Among 201 randomized subjects, data from 93 subjects in the EE/NGM group and 95 subjects in the EE/DSG group were analyzed. After 6 months of treatment with EE/NGM and EE/DSG, no differences between formulations were found for the decrease in total acne lesion counts (74.4% vs. 65.1%, respectively, p=.070) or facial improvement score. More women using EE/NGM showed a decrease in severity of facial seborrhea than those using EE/DSG (p=.005). No changes in weight were noted in either group as compared to baseline. CONCLUSION: Multiphasic OCs containing EE/NGM and EE/DSG provided comparable efficacy and tolerability in the treatment of acne. However, EE/NGM had a more beneficial effect on facial seborrhea reduction than EE/DSG. IMPLICATIONS: EE/NGM and EE/DSG are multiphasic OCs, which were shown to be clinically equally effective for mild to moderate facial acne, and the multiphasic combined OC with NGM was more effective for women with facial seborrhea. Clinicians may apply the results of this study when considering treatment options for facial acne and seborrhea. SN - 1879-0518 UR - https://www.unboundmedicine.com/medline/citation/25074072/A_comparison_of_multiphasic_oral_contraceptives_containing_norgestimate_or_desogestrel_in_acne_treatment:_a_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(14)00302-3 DB - PRIME DP - Unbound Medicine ER -