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Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men.
Eur J Clin Nutr. 2014 Oct; 68(10):1134-40.EJ

Abstract

BACKGROUND

Medium chain triglycerides (MCT) enhance thermogenesis and may reduce food intake relative to long chain triglycerides (LCT). The goal of this study was to establish the effects of MCT on appetite and food intake and determine whether differences were due to differences in hormone concentrations.

METHODS

Two randomized, crossover studies were conducted in which overweight men consumed 20 g of MCT or corn oil (LCT) at breakfast. Blood samples were obtained over 3 h. In Study 1 (n=10), an ad lib lunch was served after 3 h. In Study 2 (n=7), a preload containing 10 g of test oil was given at 3 h and lunch was served 1 h later. Linear mixed model analyses were performed to determine the effects of MCT and LCT oil on change in hormones and metabolites from fasting, adjusting for body weight. Correlations were computed between differences in hormones just before the test meals and differences in intakes after the two oils for Study 1 only.

RESULTS

Food intake at the lunch test meal after the MCT preload (Study 2) was (mean±s.e.m.) 532±389 kcal vs 804±486 kcal after LCT (P<0.05). MCT consumption resulted in a lower rise in triglycerides (P=0.014) and glucose (P=0.066) and a higher rise in peptide YY (PYY, P=0.017) and leptin (P=0.036) compared with LCT (combined data). Correlations between differences in hormone levels (glucagon-like peptide (GLP-1), PYY) and differences in food intake were in the opposite direction to expectations.

CONCLUSIONS

MCT consumption reduced food intake acutely but this does not seem to be mediated by changes in GLP-1, PYY and insulin.

Authors+Show Affiliations

1] College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.College of Physicians and Surgeons, Columbia University, New York, NY, USA.1] College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.1] College of Physicians and Surgeons, Columbia University, New York, NY, USA [2] New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.New York Obesity Nutrition Research Center, St. Luke's/Roosevelt Hospital, New York, NY, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25074387

Citation

St-Onge, M-P, et al. "Impact of Medium and Long Chain Triglycerides Consumption On Appetite and Food Intake in Overweight Men." European Journal of Clinical Nutrition, vol. 68, no. 10, 2014, pp. 1134-40.
St-Onge MP, Mayrsohn B, O'Keeffe M, et al. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. Eur J Clin Nutr. 2014;68(10):1134-40.
St-Onge, M. P., Mayrsohn, B., O'Keeffe, M., Kissileff, H. R., Choudhury, A. R., & Laferrère, B. (2014). Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. European Journal of Clinical Nutrition, 68(10), 1134-40. https://doi.org/10.1038/ejcn.2014.145
St-Onge MP, et al. Impact of Medium and Long Chain Triglycerides Consumption On Appetite and Food Intake in Overweight Men. Eur J Clin Nutr. 2014;68(10):1134-40. PubMed PMID: 25074387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. AU - St-Onge,M-P, AU - Mayrsohn,B, AU - O'Keeffe,M, AU - Kissileff,H R, AU - Choudhury,A R, AU - Laferrère,B, Y1 - 2014/07/30/ PY - 2013/12/03/received PY - 2014/05/22/revised PY - 2014/05/27/accepted PY - 2014/7/31/entrez PY - 2014/7/31/pubmed PY - 2015/7/23/medline SP - 1134 EP - 40 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 68 IS - 10 N2 - BACKGROUND: Medium chain triglycerides (MCT) enhance thermogenesis and may reduce food intake relative to long chain triglycerides (LCT). The goal of this study was to establish the effects of MCT on appetite and food intake and determine whether differences were due to differences in hormone concentrations. METHODS: Two randomized, crossover studies were conducted in which overweight men consumed 20 g of MCT or corn oil (LCT) at breakfast. Blood samples were obtained over 3 h. In Study 1 (n=10), an ad lib lunch was served after 3 h. In Study 2 (n=7), a preload containing 10 g of test oil was given at 3 h and lunch was served 1 h later. Linear mixed model analyses were performed to determine the effects of MCT and LCT oil on change in hormones and metabolites from fasting, adjusting for body weight. Correlations were computed between differences in hormones just before the test meals and differences in intakes after the two oils for Study 1 only. RESULTS: Food intake at the lunch test meal after the MCT preload (Study 2) was (mean±s.e.m.) 532±389 kcal vs 804±486 kcal after LCT (P<0.05). MCT consumption resulted in a lower rise in triglycerides (P=0.014) and glucose (P=0.066) and a higher rise in peptide YY (PYY, P=0.017) and leptin (P=0.036) compared with LCT (combined data). Correlations between differences in hormone levels (glucagon-like peptide (GLP-1), PYY) and differences in food intake were in the opposite direction to expectations. CONCLUSIONS: MCT consumption reduced food intake acutely but this does not seem to be mediated by changes in GLP-1, PYY and insulin. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/25074387/Impact_of_medium_and_long_chain_triglycerides_consumption_on_appetite_and_food_intake_in_overweight_men_ L2 - https://doi.org/10.1038/ejcn.2014.145 DB - PRIME DP - Unbound Medicine ER -