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Serum lipid profiles, lipid ratios and Chronic Kidney Disease in a Chinese population.
Int J Environ Res Public Health. 2014 Jul 29; 11(8):7622-35.IJ

Abstract

AIM

To examine the association of serum lipids, lipid ratios with Chronic Kidney Disease (CKD) in a Chinese population.

METHODS

Data were drawn from a cross-sectional survey in China. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m(2) or albuminuria-to-creatinine ratio (ACR) > 30 mg/g. Multivariable logistic regressions and multivariate regression models were used. Serum lipids and lipid ratios included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio.

RESULTS

In men, only logarithm-transformed (log) TG was associated with CKD. The odds ratio (every SD increment) was 1.39 (95% CI 1.03-1.87, P = 0.03). In women, none of the serum lipids and lipid ratios was associated with CKD. Using multivariate regression models, it was shown that log TG and log TG/HDL-C were negatively correlated with eGFR (P < 0.05) in men and LDL-C and log LDL-C/HDL-C ratio were correlated with ACR in men. In female subjects, serum TC, log TG, log TG/HDL-C and log TC/HDL-C were negatively correlated with eGFR (P < 0.05). All of serum lipid profiles and lipid related ratio were not correlated with ACR in women.

CONCLUSION

Serum TG is the only suitable predictor for CKD in men. However, in women, none of serum lipids and lipid ratio can be used as a predictor for CKD. Log TG and log TG/HDL-C are negatively correlated with eGFR in both genders.

Authors+Show Affiliations

Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. zhangliying926@126.com.Wanzai Hospital of Xiangzhou district, Zhuhai 519000, China. wzyyyzy@sina.com.Qianjin health service center of Tianhe district, Guangzhou 510000, China. dragonchw@sina.com.Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. dqydqy386@sina.com.Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. pepsi84@163.com.Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. lsky2008@yeah.net.Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. shaoxfei@126.com.Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China. hequnzou@hotmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25075881

Citation

Zhang, Liying, et al. "Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population." International Journal of Environmental Research and Public Health, vol. 11, no. 8, 2014, pp. 7622-35.
Zhang L, Yuan Z, Chen W, et al. Serum lipid profiles, lipid ratios and Chronic Kidney Disease in a Chinese population. Int J Environ Res Public Health. 2014;11(8):7622-35.
Zhang, L., Yuan, Z., Chen, W., Chen, S., Liu, X., Liang, Y., Shao, X., & Zou, H. (2014). Serum lipid profiles, lipid ratios and Chronic Kidney Disease in a Chinese population. International Journal of Environmental Research and Public Health, 11(8), 7622-35. https://doi.org/10.3390/ijerph110807622
Zhang L, et al. Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population. Int J Environ Res Public Health. 2014 Jul 29;11(8):7622-35. PubMed PMID: 25075881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum lipid profiles, lipid ratios and Chronic Kidney Disease in a Chinese population. AU - Zhang,Liying, AU - Yuan,Zhiyong, AU - Chen,Wu, AU - Chen,Shanying, AU - Liu,Xinyu, AU - Liang,Yan, AU - Shao,Xiaofei, AU - Zou,Hequn, Y1 - 2014/07/29/ PY - 2014/05/12/received PY - 2014/07/08/revised PY - 2014/07/10/accepted PY - 2014/7/31/entrez PY - 2014/7/31/pubmed PY - 2015/4/1/medline SP - 7622 EP - 35 JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 11 IS - 8 N2 - AIM: To examine the association of serum lipids, lipid ratios with Chronic Kidney Disease (CKD) in a Chinese population. METHODS: Data were drawn from a cross-sectional survey in China. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m(2) or albuminuria-to-creatinine ratio (ACR) > 30 mg/g. Multivariable logistic regressions and multivariate regression models were used. Serum lipids and lipid ratios included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio. RESULTS: In men, only logarithm-transformed (log) TG was associated with CKD. The odds ratio (every SD increment) was 1.39 (95% CI 1.03-1.87, P = 0.03). In women, none of the serum lipids and lipid ratios was associated with CKD. Using multivariate regression models, it was shown that log TG and log TG/HDL-C were negatively correlated with eGFR (P < 0.05) in men and LDL-C and log LDL-C/HDL-C ratio were correlated with ACR in men. In female subjects, serum TC, log TG, log TG/HDL-C and log TC/HDL-C were negatively correlated with eGFR (P < 0.05). All of serum lipid profiles and lipid related ratio were not correlated with ACR in women. CONCLUSION: Serum TG is the only suitable predictor for CKD in men. However, in women, none of serum lipids and lipid ratio can be used as a predictor for CKD. Log TG and log TG/HDL-C are negatively correlated with eGFR in both genders. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/25075881/Serum_lipid_profiles_lipid_ratios_and_Chronic_Kidney_Disease_in_a_Chinese_population_ L2 - https://www.mdpi.com/resolver?pii=ijerph110807622 DB - PRIME DP - Unbound Medicine ER -