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Cerebral atrophy in a vitamin B12-deficient infant of a vegetarian mother.
J Health Popul Nutr. 2014 Jun; 32(2):367-71.JH

Abstract

In developed countries, vitamin B12 (cobalamin) deficiency usually occurs in children, exclusively breastfed ones whose mothers are vegetarian, causing low body stores of vitamin B12. The haematologic manifestation of vitamin B12 deficiency is pernicious anaemia. It is a megaloblastic anaemia with high mean corpuscular volume and typical morphological features, such as hyperlobulation of the nuclei of the granulocytes. In advanced cases, neutropaenia and thrombocytopaenia can occur, simulating aplastic anaemia or leukaemia. In addition to haematological symptoms, infants may experience weakness, fatigue, failure to thrive, and irritability. Other common findings include pallor, glossitis, vomiting, diarrhoea, and icterus. Neurological symptoms may affect the central nervous system and, in severe cases, rarely cause brain atrophy. Here, we report an interesting case, a 12-month old infant, who was admitted with neurological symptoms and diagnosed with vitamin B12 deficiency.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25076673

Citation

Kocaoglu, Celebi, et al. "Cerebral Atrophy in a Vitamin B12-deficient Infant of a Vegetarian Mother." Journal of Health, Population, and Nutrition, vol. 32, no. 2, 2014, pp. 367-71.
Kocaoglu C, Akin F, Caksen H, et al. Cerebral atrophy in a vitamin B12-deficient infant of a vegetarian mother. J Health Popul Nutr. 2014;32(2):367-71.
Kocaoglu, C., Akin, F., Caksen, H., Böke, S. B., Arslan, S., & Aygün, S. (2014). Cerebral atrophy in a vitamin B12-deficient infant of a vegetarian mother. Journal of Health, Population, and Nutrition, 32(2), 367-71.
Kocaoglu C, et al. Cerebral Atrophy in a Vitamin B12-deficient Infant of a Vegetarian Mother. J Health Popul Nutr. 2014;32(2):367-71. PubMed PMID: 25076673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral atrophy in a vitamin B12-deficient infant of a vegetarian mother. AU - Kocaoglu,Celebi, AU - Akin,Fatih, AU - Caksen,Hüseyin, AU - Böke,Saltuk Buğra, AU - Arslan,Sükrü, AU - Aygün,Serhat, PY - 2014/8/1/entrez PY - 2014/8/1/pubmed PY - 2014/8/29/medline SP - 367 EP - 71 JF - Journal of health, population, and nutrition JO - J Health Popul Nutr VL - 32 IS - 2 N2 - In developed countries, vitamin B12 (cobalamin) deficiency usually occurs in children, exclusively breastfed ones whose mothers are vegetarian, causing low body stores of vitamin B12. The haematologic manifestation of vitamin B12 deficiency is pernicious anaemia. It is a megaloblastic anaemia with high mean corpuscular volume and typical morphological features, such as hyperlobulation of the nuclei of the granulocytes. In advanced cases, neutropaenia and thrombocytopaenia can occur, simulating aplastic anaemia or leukaemia. In addition to haematological symptoms, infants may experience weakness, fatigue, failure to thrive, and irritability. Other common findings include pallor, glossitis, vomiting, diarrhoea, and icterus. Neurological symptoms may affect the central nervous system and, in severe cases, rarely cause brain atrophy. Here, we report an interesting case, a 12-month old infant, who was admitted with neurological symptoms and diagnosed with vitamin B12 deficiency. SN - 1606-0997 UR - https://www.unboundmedicine.com/medline/citation/25076673/Cerebral_atrophy_in_a_vitamin_B12_deficient_infant_of_a_vegetarian_mother_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25076673/ DB - PRIME DP - Unbound Medicine ER -