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A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study.
Lipids Health Dis. 2014 Jul 31; 13:121.LH

Abstract

BACKGROUND

Supplementation with a phosphatidylserine and phosphatidylserine/ phosphatidic acid complex (PAS) has been observed to normalize stress induced dysregulations of the hypothalamus-pituitary-adrenal axis (HPAA). Prolonged stress first induces a hyper-activation of the HPAA, which then can be followed by a state of hypo-activation.The aim of this study was to examine effects of an oral supplementation with 400 mg PS & 400 mg PA (PAS 400) per day on the endocrine stress response (ACTH, saliva and serum cortisol) to a psychosocial stressor. A special focus was to analyze subgroups of low versus high chronically stressed subjects as well as to test efficacy of 200 mg PS & 200 mg PA (PAS 200).

METHODS

75 healthy male volunteers were enrolled for this double-blind, placebo-controlled study, stratified by chronic stress level, and randomly allocated to one of three study arms (placebo, PAS 200 and PAS 400 per day, respectively). Study supplementation was administered for 42 days for each participant. Chronic stress was measured with the Trier Inventory for Chronic Stress (TICS), and subgroups of high and low chronic stress were differentiated by median values as provided by the TICS authors. A six week period of supplementation was followed by an acute stress test (Trier Social Stress Test - TSST).

RESULTS

Chronic stress levels and other baseline measures did not differ between treatment groups (all p>0.05). Acute stress was successfully induced by the TSST and resulted in a hyper-responsivity of the HPAA in chronically stressed subjects. Compared to placebo, a supplementation with a daily dose of PAS 400 was effective in normalizing the ACTH (p=0.010), salivary (p=0.043) and serum cortisol responses (p=0.035) to the TSST in chronically high but not in low stressed subjects (all p>0.05). Compared to placebo, supplementation with PAS 200 did not result in any significant differences in these variables (all p>0.05). There were no significant effects of supplementation with PAS on heart rate, pulse transit time, or psychological stress response (all p>0.05).

CONCLUSION

In chronically stressed subjects, a supplementation with PAS 400 (MemreePlus™) can normalize the hyper-responsivity of the HPAA to an acute stressor.

TRIAL REGISTRATION

TRIAL REGISTRATION

DRKS-ID: DRKS00005125.

Authors+Show Affiliations

Diagnostic Assessment and Clinical Research Organization (Daacro) GmbH & Co, KG, Science Park Trier, Max-Planck-Str, 22, 54296 Trier, Germany. hellhammer@daacro.de.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25081826

Citation

Hellhammer, Juliane, et al. "A Soy-based Phosphatidylserine/ Phosphatidic Acid Complex (PAS) Normalizes the Stress Reactivity of Hypothalamus-pituitary-adrenal-axis in Chronically Stressed Male Subjects: a Randomized, Placebo-controlled Study." Lipids in Health and Disease, vol. 13, 2014, p. 121.
Hellhammer J, Vogt D, Franz N, et al. A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids Health Dis. 2014;13:121.
Hellhammer, J., Vogt, D., Franz, N., Freitas, U., & Rutenberg, D. (2014). A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. Lipids in Health and Disease, 13, 121. https://doi.org/10.1186/1476-511X-13-121
Hellhammer J, et al. A Soy-based Phosphatidylserine/ Phosphatidic Acid Complex (PAS) Normalizes the Stress Reactivity of Hypothalamus-pituitary-adrenal-axis in Chronically Stressed Male Subjects: a Randomized, Placebo-controlled Study. Lipids Health Dis. 2014 Jul 31;13:121. PubMed PMID: 25081826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A soy-based phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study. AU - Hellhammer,Juliane, AU - Vogt,Dominic, AU - Franz,Nadin, AU - Freitas,Ulla, AU - Rutenberg,David, Y1 - 2014/07/31/ PY - 2014/05/16/received PY - 2014/07/21/accepted PY - 2014/8/2/entrez PY - 2014/8/2/pubmed PY - 2015/3/31/medline SP - 121 EP - 121 JF - Lipids in health and disease JO - Lipids Health Dis VL - 13 N2 - BACKGROUND: Supplementation with a phosphatidylserine and phosphatidylserine/ phosphatidic acid complex (PAS) has been observed to normalize stress induced dysregulations of the hypothalamus-pituitary-adrenal axis (HPAA). Prolonged stress first induces a hyper-activation of the HPAA, which then can be followed by a state of hypo-activation.The aim of this study was to examine effects of an oral supplementation with 400 mg PS & 400 mg PA (PAS 400) per day on the endocrine stress response (ACTH, saliva and serum cortisol) to a psychosocial stressor. A special focus was to analyze subgroups of low versus high chronically stressed subjects as well as to test efficacy of 200 mg PS & 200 mg PA (PAS 200). METHODS: 75 healthy male volunteers were enrolled for this double-blind, placebo-controlled study, stratified by chronic stress level, and randomly allocated to one of three study arms (placebo, PAS 200 and PAS 400 per day, respectively). Study supplementation was administered for 42 days for each participant. Chronic stress was measured with the Trier Inventory for Chronic Stress (TICS), and subgroups of high and low chronic stress were differentiated by median values as provided by the TICS authors. A six week period of supplementation was followed by an acute stress test (Trier Social Stress Test - TSST). RESULTS: Chronic stress levels and other baseline measures did not differ between treatment groups (all p>0.05). Acute stress was successfully induced by the TSST and resulted in a hyper-responsivity of the HPAA in chronically stressed subjects. Compared to placebo, a supplementation with a daily dose of PAS 400 was effective in normalizing the ACTH (p=0.010), salivary (p=0.043) and serum cortisol responses (p=0.035) to the TSST in chronically high but not in low stressed subjects (all p>0.05). Compared to placebo, supplementation with PAS 200 did not result in any significant differences in these variables (all p>0.05). There were no significant effects of supplementation with PAS on heart rate, pulse transit time, or psychological stress response (all p>0.05). CONCLUSION: In chronically stressed subjects, a supplementation with PAS 400 (MemreePlus™) can normalize the hyper-responsivity of the HPAA to an acute stressor. TRIAL REGISTRATION: TRIAL REGISTRATION: DRKS-ID: DRKS00005125. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/25081826/A_soy_based_phosphatidylserine/_phosphatidic_acid_complex__PAS__normalizes_the_stress_reactivity_of_hypothalamus_pituitary_adrenal_axis_in_chronically_stressed_male_subjects:_a_randomized_placebo_controlled_study_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-121 DB - PRIME DP - Unbound Medicine ER -