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[Use of prostacyclin in the treatment of patients with chronic occlusion of the peripheral arteries (stage IV)].
Srp Arh Celok Lek. 1989 Jan-Feb; 117(1-2):17-25.SA

Abstract

Preliminary results of the use of prostacyclin in 6 patients with peripheral arterial occlusive disease (IV stage) are presented. Diagnosis was supported by clinical signs, Doppler ultrasound and arteriography. There were 4 diabetics, one with Mb Bürger and the other with obliterant atherosclerosis. All patients were unsuccessful by treated with antiaggregants, vasodilators and haemorheological medicaments. The reconstructive vascular surgery was also impossible. However amputation was necessary. The patients treated by intra-venous and intra-arterial prostacyclin administration in the dose of 5 ng/kg b.w./min during different periods of time (24, 48, 72 h). During intrahospital treatment complete relief of pain and gangrene demarcation in all patients. One month later two patients manifested necrotic progression and amputation of a limb was necessary. The long-term clinical success was registered in 4 patients (1-16) months). Indications, doses, side effects of prostacyclin action are discussed.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

srp

PubMed ID

2508243

Citation

Maksimović, Z, et al. "[Use of Prostacyclin in the Treatment of Patients With Chronic Occlusion of the Peripheral Arteries (stage IV)]." Srpski Arhiv Za Celokupno Lekarstvo, vol. 117, no. 1-2, 1989, pp. 17-25.
Maksimović Z, Djukić V, Lotina S, et al. [Use of prostacyclin in the treatment of patients with chronic occlusion of the peripheral arteries (stage IV)]. Srp Arh Celok Lek. 1989;117(1-2):17-25.
Maksimović, Z., Djukić, V., Lotina, S., Mujović, V., & Radak, D. j. (1989). [Use of prostacyclin in the treatment of patients with chronic occlusion of the peripheral arteries (stage IV)]. Srpski Arhiv Za Celokupno Lekarstvo, 117(1-2), 17-25.
Maksimović Z, et al. [Use of Prostacyclin in the Treatment of Patients With Chronic Occlusion of the Peripheral Arteries (stage IV)]. Srp Arh Celok Lek. 1989 Jan-Feb;117(1-2):17-25. PubMed PMID: 2508243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Use of prostacyclin in the treatment of patients with chronic occlusion of the peripheral arteries (stage IV)]. AU - Maksimović,Z, AU - Djukić,V, AU - Lotina,S, AU - Mujović,V, AU - Radak,Dj, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 17 EP - 25 JF - Srpski arhiv za celokupno lekarstvo JO - Srp Arh Celok Lek VL - 117 IS - 1-2 N2 - Preliminary results of the use of prostacyclin in 6 patients with peripheral arterial occlusive disease (IV stage) are presented. Diagnosis was supported by clinical signs, Doppler ultrasound and arteriography. There were 4 diabetics, one with Mb Bürger and the other with obliterant atherosclerosis. All patients were unsuccessful by treated with antiaggregants, vasodilators and haemorheological medicaments. The reconstructive vascular surgery was also impossible. However amputation was necessary. The patients treated by intra-venous and intra-arterial prostacyclin administration in the dose of 5 ng/kg b.w./min during different periods of time (24, 48, 72 h). During intrahospital treatment complete relief of pain and gangrene demarcation in all patients. One month later two patients manifested necrotic progression and amputation of a limb was necessary. The long-term clinical success was registered in 4 patients (1-16) months). Indications, doses, side effects of prostacyclin action are discussed. SN - 0370-8179 UR - https://www.unboundmedicine.com/medline/citation/2508243/[Use_of_prostacyclin_in_the_treatment_of_patients_with_chronic_occlusion_of_the_peripheral_arteries__stage_IV_]_ DB - PRIME DP - Unbound Medicine ER -