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Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes.
J Asian Nat Prod Res. 2014; 16(11):1074-83.JA

Abstract

Adiponectin, an adipokine with insulin-sensitizing effect, is secreted from adipocytes into circulation as high, medium, and low molecular weight (HMW, MMW, and LMW) forms. The HMW adiponectin is more metabolically active and the ratio of HMW adiponectin to total adiponectin directly correlates with insulin sensitivity. Evodiamine is an indole alkaloid found in the traditional Chinese medicinal plant Evodia rutaecarpa. In this study, evodiamine was found to activate AMP-activated protein kinase (AMPK) in both 3T3-L1 adipocytes and 293T cells. Activation of AMPK by evodiamine promoted the assembly of HMW adiponectin and increased the HMW/total ratio of adiponectin in 3T3-L1 adipocytes. The Ca(2+)-dependent PI3K/Akt/CaMKII-signaling pathway was demonstrated to be involved in evodiamine-induced AMPK activation. This study revealed a novel role of this Ca(2+)-mediated signaling pathway in promoting the multimerization of adiponectin.

Authors+Show Affiliations

a MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University , Beijing 100084 , China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25082563

Citation

Liu, Long-Hua, et al. "Evodiamine Activates AMPK and Promotes Adiponectin Multimerization in 3T3-L1 Adipocytes." Journal of Asian Natural Products Research, vol. 16, no. 11, 2014, pp. 1074-83.
Liu LH, Xie JY, Guo WW, et al. Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes. J Asian Nat Prod Res. 2014;16(11):1074-83.
Liu, L. H., Xie, J. Y., Guo, W. W., Wu, G. Y., Chen, Z. F., Yi, J. Y., Zhang, L., Zhang, Z. J., & Li, Z. (2014). Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes. Journal of Asian Natural Products Research, 16(11), 1074-83. https://doi.org/10.1080/10286020.2014.939071
Liu LH, et al. Evodiamine Activates AMPK and Promotes Adiponectin Multimerization in 3T3-L1 Adipocytes. J Asian Nat Prod Res. 2014;16(11):1074-83. PubMed PMID: 25082563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes. AU - Liu,Long-Hua, AU - Xie,Jin-Yan, AU - Guo,Wen-Wen, AU - Wu,Guo-Yu, AU - Chen,Zhi-Fen, AU - Yi,Jun-Yang, AU - Zhang,Lu, AU - Zhang,Zhi-Jie, AU - Li,Zhen, Y1 - 2014/08/01/ PY - 2014/8/2/entrez PY - 2014/8/2/pubmed PY - 2015/1/13/medline KW - AMPK KW - CaMKII KW - adiponectin KW - evodiamine KW - multimerization SP - 1074 EP - 83 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 16 IS - 11 N2 - Adiponectin, an adipokine with insulin-sensitizing effect, is secreted from adipocytes into circulation as high, medium, and low molecular weight (HMW, MMW, and LMW) forms. The HMW adiponectin is more metabolically active and the ratio of HMW adiponectin to total adiponectin directly correlates with insulin sensitivity. Evodiamine is an indole alkaloid found in the traditional Chinese medicinal plant Evodia rutaecarpa. In this study, evodiamine was found to activate AMP-activated protein kinase (AMPK) in both 3T3-L1 adipocytes and 293T cells. Activation of AMPK by evodiamine promoted the assembly of HMW adiponectin and increased the HMW/total ratio of adiponectin in 3T3-L1 adipocytes. The Ca(2+)-dependent PI3K/Akt/CaMKII-signaling pathway was demonstrated to be involved in evodiamine-induced AMPK activation. This study revealed a novel role of this Ca(2+)-mediated signaling pathway in promoting the multimerization of adiponectin. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/25082563/Evodiamine_activates_AMPK_and_promotes_adiponectin_multimerization_in_3T3_L1_adipocytes_ L2 - http://www.tandfonline.com/doi/full/10.1080/10286020.2014.939071 DB - PRIME DP - Unbound Medicine ER -