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Smoking, drinking, and pancreatitis: a population-based cohort study in Taiwan.
Pancreas 2014; 43(7):1117-22P

Abstract

OBJECTIVES

In Western population, smoking is a dose-dependent risk factor for pancreatitis, whereas a threshold of 5 drinks per day may exist for alcohol to increase pancreatitis risk. Given ethnic differences in tobacco and alcohol metabolism, we examined the associations between smoking, alcohol, and pancreatitis in Asians.

METHODS

A population-based cohort was assembled using participants of the National Health Interview Survey in Taiwan. Information on drinking and smoking was collected by in-person interview at baseline. Incident cases of pancreatitis were identified through data linkage with National Health Insurance claims database.

RESULTS

During 94,601 person-years of follow-up, 66 incident cases of pancreatitis occurred. Neither current nor ever smoking was associated with the incidence of pancreatitis (adjusted hazard ratio [aHR] 1.13; 95% confidence interval [CI], 0.62-2.06; and aHR, 1.14; 95% CI, 0.63-2.06, respectively). Dose-response analysis also showed no association between smoking and pancreatitis. By contrast, regular (aHR, 3.09; 95% CI, 1.51-6.30) and heavy alcohol drinking (aHR, 6.46; 95% CI, 3.07-13.60) were associated with an increased incidence of pancreatitis compared with abstinence.

CONCLUSIONS

In this Asian population-based cohort, alcohol was associated with pancreatitis in a dose-dependent way, but smoking was not associated with pancreatitis. These results support for ethnic differences in susceptibility to smoking- and alcohol-related pancreatitis.

Authors+Show Affiliations

From the *Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei; †Institute of Population Health, National Health Research Institutes, Miaoli County, Taiwan; ‡Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei; and §School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25083998

Citation

Lin, Hsien-Ho, et al. "Smoking, Drinking, and Pancreatitis: a Population-based Cohort Study in Taiwan." Pancreas, vol. 43, no. 7, 2014, pp. 1117-22.
Lin HH, Chang HY, Chiang YT, et al. Smoking, drinking, and pancreatitis: a population-based cohort study in Taiwan. Pancreas. 2014;43(7):1117-22.
Lin, H. H., Chang, H. Y., Chiang, Y. T., Wu, M. S., Lin, J. T., & Liao, W. C. (2014). Smoking, drinking, and pancreatitis: a population-based cohort study in Taiwan. Pancreas, 43(7), pp. 1117-22. doi:10.1097/MPA.0000000000000209.
Lin HH, et al. Smoking, Drinking, and Pancreatitis: a Population-based Cohort Study in Taiwan. Pancreas. 2014;43(7):1117-22. PubMed PMID: 25083998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking, drinking, and pancreatitis: a population-based cohort study in Taiwan. AU - Lin,Hsien-Ho, AU - Chang,Hsing-Yi, AU - Chiang,Yi-Ting, AU - Wu,Ming-Shiang, AU - Lin,Jaw-Town, AU - Liao,Wei-Chih, PY - 2014/8/2/entrez PY - 2014/8/2/pubmed PY - 2015/5/26/medline SP - 1117 EP - 22 JF - Pancreas JO - Pancreas VL - 43 IS - 7 N2 - OBJECTIVES: In Western population, smoking is a dose-dependent risk factor for pancreatitis, whereas a threshold of 5 drinks per day may exist for alcohol to increase pancreatitis risk. Given ethnic differences in tobacco and alcohol metabolism, we examined the associations between smoking, alcohol, and pancreatitis in Asians. METHODS: A population-based cohort was assembled using participants of the National Health Interview Survey in Taiwan. Information on drinking and smoking was collected by in-person interview at baseline. Incident cases of pancreatitis were identified through data linkage with National Health Insurance claims database. RESULTS: During 94,601 person-years of follow-up, 66 incident cases of pancreatitis occurred. Neither current nor ever smoking was associated with the incidence of pancreatitis (adjusted hazard ratio [aHR] 1.13; 95% confidence interval [CI], 0.62-2.06; and aHR, 1.14; 95% CI, 0.63-2.06, respectively). Dose-response analysis also showed no association between smoking and pancreatitis. By contrast, regular (aHR, 3.09; 95% CI, 1.51-6.30) and heavy alcohol drinking (aHR, 6.46; 95% CI, 3.07-13.60) were associated with an increased incidence of pancreatitis compared with abstinence. CONCLUSIONS: In this Asian population-based cohort, alcohol was associated with pancreatitis in a dose-dependent way, but smoking was not associated with pancreatitis. These results support for ethnic differences in susceptibility to smoking- and alcohol-related pancreatitis. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/25083998/Smoking_drinking_and_pancreatitis:_a_population_based_cohort_study_in_Taiwan_ L2 - http://Insights.ovid.com/pubmed?pmid=25083998 DB - PRIME DP - Unbound Medicine ER -