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Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity--secondary analysis from the ROLO study.

Abstract

BACKGROUND

The in utero environment is known to affect fetal development however many of the mechanisms by which this occurs remain unknown. The aim of this study was to examine the association between maternal dietary macronutrient intake and lifestyle throughout pregnancy and neonatal weight and adiposity.

METHODS

This was an analysis of 542 mother and infant pairs from the ROLO study (Randomised cOntrol trial of LOw glycaemic index diet versus no dietary intervention to prevent recurrence of fetal macrosomia). Food diaries as well as food frequency and lifestyle and physical activity questionnaires were completed during pregnancy. Maternal anthropometry was measured throughout pregnancy and neonatal anthropometry was measured at birth.

RESULTS

Multiple linear regression analysis revealed the main maternal factor associated with increased birth weight was greater gestational weight gain R2adj 23.3% (F = 11.547, p < 0.001). The main maternal factor associated with increased birth length was non-smoking status R2adj 27.8% (F = 6.193, p < 0.001). Neonatal central adiposity (determined using waist:length ratio) was negatively associated with maternal age, and positively associated with the following parameters: smoking status, maternal pre-pregnancy arm circumference, percentage energy from saturated fat in late pregnancy, postprandial glucose at 28 weeks gestation and membership of the control group with a positive trend towards association with trimester 2 glycaemic load R2adj 38.1% (F = 8.000, p < 0.001).

CONCLUSIONS

Several maternal diet and lifestyle factors were associated with neonatal anthropometry . Low glycaemic index dietary intervention in pregnancy was found to have a beneficial effect on neonatal central adiposity. Additionally, central adiposity was positively associated with maternal dietary fat intake and postprandial glucose highlighting the important role of healthy diet in pregnancy in promoting normal neonatal adiposity.

TRIAL REGISTRATION

Current Controlled Trials ISRCTN54392969.

Links

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  • Authors+Show Affiliations

    , , , ,

    UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin 2, Ireland. fionnuala.mcauliffe@ucd.ie.

    Source

    Nutrition journal 13: 2014 Aug 01 pg 78

    MeSH

    Adiposity
    Adult
    Blood Glucose
    Body Height
    Body Mass Index
    Body Weight
    Diet
    Diet Records
    Dietary Carbohydrates
    Dietary Fats
    Dietary Proteins
    Energy Intake
    Fatty Acids
    Fatty Acids, Monounsaturated
    Fatty Acids, Unsaturated
    Feeding Behavior
    Female
    Fetal Macrosomia
    Glucose Tolerance Test
    Glycemic Index
    Humans
    Infant
    Life Style
    Linear Models
    Maternal Nutritional Physiological Phenomena
    Postprandial Period
    Pregnancy
    Surveys and Questionnaires
    Weight Gain

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25084967

    Citation

    Horan, Mary K., et al. "Maternal Low Glycaemic Index Diet, Fat Intake and Postprandial Glucose Influences Neonatal Adiposity--secondary Analysis From the ROLO Study." Nutrition Journal, vol. 13, 2014, p. 78.
    Horan MK, McGowan CA, Gibney ER, et al. Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity--secondary analysis from the ROLO study. Nutr J. 2014;13:78.
    Horan, M. K., McGowan, C. A., Gibney, E. R., Donnelly, J. M., & McAuliffe, F. M. (2014). Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity--secondary analysis from the ROLO study. Nutrition Journal, 13, p. 78. doi:10.1186/1475-2891-13-78.
    Horan MK, et al. Maternal Low Glycaemic Index Diet, Fat Intake and Postprandial Glucose Influences Neonatal Adiposity--secondary Analysis From the ROLO Study. Nutr J. 2014 Aug 1;13:78. PubMed PMID: 25084967.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity--secondary analysis from the ROLO study. AU - Horan,Mary K, AU - McGowan,Ciara A, AU - Gibney,Eileen R, AU - Donnelly,Jean M, AU - McAuliffe,Fionnuala M, Y1 - 2014/08/01/ PY - 2014/04/03/received PY - 2014/07/08/accepted PY - 2014/8/3/entrez PY - 2014/8/3/pubmed PY - 2015/3/31/medline SP - 78 EP - 78 JF - Nutrition journal JO - Nutr J VL - 13 N2 - BACKGROUND: The in utero environment is known to affect fetal development however many of the mechanisms by which this occurs remain unknown. The aim of this study was to examine the association between maternal dietary macronutrient intake and lifestyle throughout pregnancy and neonatal weight and adiposity. METHODS: This was an analysis of 542 mother and infant pairs from the ROLO study (Randomised cOntrol trial of LOw glycaemic index diet versus no dietary intervention to prevent recurrence of fetal macrosomia). Food diaries as well as food frequency and lifestyle and physical activity questionnaires were completed during pregnancy. Maternal anthropometry was measured throughout pregnancy and neonatal anthropometry was measured at birth. RESULTS: Multiple linear regression analysis revealed the main maternal factor associated with increased birth weight was greater gestational weight gain R2adj 23.3% (F = 11.547, p < 0.001). The main maternal factor associated with increased birth length was non-smoking status R2adj 27.8% (F = 6.193, p < 0.001). Neonatal central adiposity (determined using waist:length ratio) was negatively associated with maternal age, and positively associated with the following parameters: smoking status, maternal pre-pregnancy arm circumference, percentage energy from saturated fat in late pregnancy, postprandial glucose at 28 weeks gestation and membership of the control group with a positive trend towards association with trimester 2 glycaemic load R2adj 38.1% (F = 8.000, p < 0.001). CONCLUSIONS: Several maternal diet and lifestyle factors were associated with neonatal anthropometry . Low glycaemic index dietary intervention in pregnancy was found to have a beneficial effect on neonatal central adiposity. Additionally, central adiposity was positively associated with maternal dietary fat intake and postprandial glucose highlighting the important role of healthy diet in pregnancy in promoting normal neonatal adiposity. TRIAL REGISTRATION: Current Controlled Trials ISRCTN54392969. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/25084967/Maternal_low_glycaemic_index_diet_fat_intake_and_postprandial_glucose_influences_neonatal_adiposity__secondary_analysis_from_the_ROLO_study_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-78 DB - PRIME DP - Unbound Medicine ER -