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Vitamin D in blood and risk of prostate cancer: lessons from the Selenium and Vitamin E Cancer Prevention Trial and the Prostate Cancer Prevention Trial.

Abstract

The effects of blood levels of 25-hydroxyvitamin D (25-OHD) on the risk of total, low-, and high-grade prostate cancer were examined in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and the Prostate Cancer Prevention Trial (PCPT). In the SELECT study, plasma 25-OHD levels were associated with a linear decrease in prostate cancer risk for high-grade cancers in African American men and an apparent "U"-shaped effect in other men. The "U-shaped" curve may reflect detection bias. In the PCPT study, in which detection bias was minimized, serum 25-OHD levels were associated with a linear decrease in the risk of high-grade prostate cancers. The results from these large prevention trials support the hypothesis that circulating levels of 25-OHD decrease the risk of clinically relevant prostate cancers.

Authors+Show Affiliations

Departments of Cancer Biology, Urology, and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina gschwart@wakehealth.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25085835

Citation

Schwartz, Gary G.. "Vitamin D in Blood and Risk of Prostate Cancer: Lessons From the Selenium and Vitamin E Cancer Prevention Trial and the Prostate Cancer Prevention Trial." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 23, no. 8, 2014, pp. 1447-9.
Schwartz GG. Vitamin D in blood and risk of prostate cancer: lessons from the Selenium and Vitamin E Cancer Prevention Trial and the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev. 2014;23(8):1447-9.
Schwartz, G. G. (2014). Vitamin D in blood and risk of prostate cancer: lessons from the Selenium and Vitamin E Cancer Prevention Trial and the Prostate Cancer Prevention Trial. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 23(8), pp. 1447-9. doi:10.1158/1055-9965.EPI-14-0520.
Schwartz GG. Vitamin D in Blood and Risk of Prostate Cancer: Lessons From the Selenium and Vitamin E Cancer Prevention Trial and the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev. 2014;23(8):1447-9. PubMed PMID: 25085835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D in blood and risk of prostate cancer: lessons from the Selenium and Vitamin E Cancer Prevention Trial and the Prostate Cancer Prevention Trial. A1 - Schwartz,Gary G, PY - 2014/8/3/entrez PY - 2014/8/3/pubmed PY - 2015/6/19/medline SP - 1447 EP - 9 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 23 IS - 8 N2 - The effects of blood levels of 25-hydroxyvitamin D (25-OHD) on the risk of total, low-, and high-grade prostate cancer were examined in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and the Prostate Cancer Prevention Trial (PCPT). In the SELECT study, plasma 25-OHD levels were associated with a linear decrease in prostate cancer risk for high-grade cancers in African American men and an apparent "U"-shaped effect in other men. The "U-shaped" curve may reflect detection bias. In the PCPT study, in which detection bias was minimized, serum 25-OHD levels were associated with a linear decrease in the risk of high-grade prostate cancers. The results from these large prevention trials support the hypothesis that circulating levels of 25-OHD decrease the risk of clinically relevant prostate cancers. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/25085835/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=25085835 DB - PRIME DP - Unbound Medicine ER -