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Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach.
Magn Reson Imaging. 2014 Dec; 32(10):1301-6.MR

Abstract

Quantitative MRI of neuromelanin (NM) containing structures (referred to as NM-MRI) in the brainstem, namely the locus coeruleus (LC) and substantia nigra (SN), may assist with the early detection of Parkinson's disease (PD) and Alzheimer's disease (AD) as well as differential diagnosis in the early disease stages. In this study, two gradient echo (GRE) sequences with magnetization transfer contrast (MTC) preparation pulses were developed to simultaneously image the LC and SN. This has been a challenge with NM-MRI techniques used in previous studies due to the relatively high specific absorption rate (SAR) induced by these techniques. In addition, a semi-automated quantitative analysis scheme was applied to estimate volumes and contrast-to-noise ratios (CNR) of the LC and SN based on segmentation of both structures. Compared to a T1-weighted turbo spin echo (TSE) sequence typically used for simultaneous imaging of the LC and SN, the two GRE-MTC sequences exhibited improved performance in terms of higher sensitivity (in CNR) in imaging the SN and lower SAR during the scans. A multiple-measurement protocol was adopted as well so that motion degraded measurements could be removed and artifacts associated with motion could be corrected. The present approach has demonstrated advantages in image acquisition (lower SAR and higher sensitivity), image pre-processing (with motion correction) and quantitative image analysis (segmentation-based estimation of volume and CNR) when compared with existing NM-MRI approaches. This approach has potential for detection and monitoring of neurodegeneration in LC and SN in disease states including AD and PD.

Authors+Show Affiliations

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.Department of Neurology, Emory University, Atlanta, GA; Center for Health Research Southeast, Kaiser Permanente, Atlanta, GA.Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.Department of Physiology, Emory University, Atlanta, GA.Department of Neurology, Emory University, Atlanta, GA.Department of Neurology, Emory University, Atlanta, GA.Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA. Electronic address: xhu3@emory.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25086330

Citation

Chen, Xiangchuan, et al. "Simultaneous Imaging of Locus Coeruleus and Substantia Nigra With a Quantitative Neuromelanin MRI Approach." Magnetic Resonance Imaging, vol. 32, no. 10, 2014, pp. 1301-6.
Chen X, Huddleston DE, Langley J, et al. Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach. Magn Reson Imaging. 2014;32(10):1301-6.
Chen, X., Huddleston, D. E., Langley, J., Ahn, S., Barnum, C. J., Factor, S. A., Levey, A. I., & Hu, X. (2014). Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach. Magnetic Resonance Imaging, 32(10), 1301-6. https://doi.org/10.1016/j.mri.2014.07.003
Chen X, et al. Simultaneous Imaging of Locus Coeruleus and Substantia Nigra With a Quantitative Neuromelanin MRI Approach. Magn Reson Imaging. 2014;32(10):1301-6. PubMed PMID: 25086330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous imaging of locus coeruleus and substantia nigra with a quantitative neuromelanin MRI approach. AU - Chen,Xiangchuan, AU - Huddleston,Daniel E, AU - Langley,Jason, AU - Ahn,Sinyeob, AU - Barnum,Christopher J, AU - Factor,Stewart A, AU - Levey,Allan I, AU - Hu,Xiaoping, Y1 - 2014/07/31/ PY - 2014/02/27/received PY - 2014/06/17/revised PY - 2014/07/24/accepted PY - 2014/8/3/entrez PY - 2014/8/3/pubmed PY - 2015/8/1/medline KW - Locus coeruleus KW - Neuromelanin MRI KW - Quantitative measurement KW - Substantia nigra SP - 1301 EP - 6 JF - Magnetic resonance imaging JO - Magn Reson Imaging VL - 32 IS - 10 N2 - Quantitative MRI of neuromelanin (NM) containing structures (referred to as NM-MRI) in the brainstem, namely the locus coeruleus (LC) and substantia nigra (SN), may assist with the early detection of Parkinson's disease (PD) and Alzheimer's disease (AD) as well as differential diagnosis in the early disease stages. In this study, two gradient echo (GRE) sequences with magnetization transfer contrast (MTC) preparation pulses were developed to simultaneously image the LC and SN. This has been a challenge with NM-MRI techniques used in previous studies due to the relatively high specific absorption rate (SAR) induced by these techniques. In addition, a semi-automated quantitative analysis scheme was applied to estimate volumes and contrast-to-noise ratios (CNR) of the LC and SN based on segmentation of both structures. Compared to a T1-weighted turbo spin echo (TSE) sequence typically used for simultaneous imaging of the LC and SN, the two GRE-MTC sequences exhibited improved performance in terms of higher sensitivity (in CNR) in imaging the SN and lower SAR during the scans. A multiple-measurement protocol was adopted as well so that motion degraded measurements could be removed and artifacts associated with motion could be corrected. The present approach has demonstrated advantages in image acquisition (lower SAR and higher sensitivity), image pre-processing (with motion correction) and quantitative image analysis (segmentation-based estimation of volume and CNR) when compared with existing NM-MRI approaches. This approach has potential for detection and monitoring of neurodegeneration in LC and SN in disease states including AD and PD. SN - 1873-5894 UR - https://www.unboundmedicine.com/medline/citation/25086330/Simultaneous_imaging_of_locus_coeruleus_and_substantia_nigra_with_a_quantitative_neuromelanin_MRI_approach_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0730-725X(14)00206-9 DB - PRIME DP - Unbound Medicine ER -