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Evaluation of replication of variants associated with genetic risk of otitis media.
PLoS One. 2014; 9(8):e104212.Plos

Abstract

The first Genome Wide Association Study (GWAS) of otitis media (OM) found evidence of association in the Western Australian Pregnancy Cohort (Raine) study, but lacked replication in an independent OM population. The aim of this study was to investigate association at these loci in our family-based sample of chronic otitis media with effusion and recurrent otitis media (COME/ROM). Autosomal SNPs were selected from the Raine OM GWAS results. SNPs from the Raine cohort GWAS genotyped in our GWAS of COME/ROM had P-values ranging from P = 0.06-0.80. After removal of SNPs previously genotyped in our GWAS of COME/ROM (N = 21) and those that failed Fluidigm assay design (N = 1), 26 SNPs were successfully genotyped in 716 individuals from our COME/ROM family population. None of the SNP associations replicated in our family-based population (unadjusted P = 0.03-0.93). Replication in an independent sample would confirm that these represent novel OM loci, and that further investigation is warranted.

Authors+Show Affiliations

Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America.Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America.Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America.Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America; Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America.Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, United States of America.Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25089819

Citation

Allen, E Kaitlynn, et al. "Evaluation of Replication of Variants Associated With Genetic Risk of Otitis Media." PloS One, vol. 9, no. 8, 2014, pp. e104212.
Allen EK, Manichaikul A, Chen WM, et al. Evaluation of replication of variants associated with genetic risk of otitis media. PLoS One. 2014;9(8):e104212.
Allen, E. K., Manichaikul, A., Chen, W. M., Rich, S. S., Daly, K. A., & Sale, M. M. (2014). Evaluation of replication of variants associated with genetic risk of otitis media. PloS One, 9(8), e104212. https://doi.org/10.1371/journal.pone.0104212
Allen EK, et al. Evaluation of Replication of Variants Associated With Genetic Risk of Otitis Media. PLoS One. 2014;9(8):e104212. PubMed PMID: 25089819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of replication of variants associated with genetic risk of otitis media. AU - Allen,E Kaitlynn, AU - Manichaikul,Ani, AU - Chen,Wei-Min, AU - Rich,Stephen S, AU - Daly,Kathleen A, AU - Sale,Michèle M, Y1 - 2014/08/04/ PY - 2014/01/07/received PY - 2014/07/11/accepted PY - 2014/8/5/entrez PY - 2014/8/5/pubmed PY - 2015/11/17/medline SP - e104212 EP - e104212 JF - PloS one JO - PLoS One VL - 9 IS - 8 N2 - The first Genome Wide Association Study (GWAS) of otitis media (OM) found evidence of association in the Western Australian Pregnancy Cohort (Raine) study, but lacked replication in an independent OM population. The aim of this study was to investigate association at these loci in our family-based sample of chronic otitis media with effusion and recurrent otitis media (COME/ROM). Autosomal SNPs were selected from the Raine OM GWAS results. SNPs from the Raine cohort GWAS genotyped in our GWAS of COME/ROM had P-values ranging from P = 0.06-0.80. After removal of SNPs previously genotyped in our GWAS of COME/ROM (N = 21) and those that failed Fluidigm assay design (N = 1), 26 SNPs were successfully genotyped in 716 individuals from our COME/ROM family population. None of the SNP associations replicated in our family-based population (unadjusted P = 0.03-0.93). Replication in an independent sample would confirm that these represent novel OM loci, and that further investigation is warranted. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25089819/Evaluation_of_replication_of_variants_associated_with_genetic_risk_of_otitis_media_ L2 - https://dx.plos.org/10.1371/journal.pone.0104212 DB - PRIME DP - Unbound Medicine ER -