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Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults.

Abstract

The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake (n=116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α (p<0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α (p=0.001); higher quartiles of arachidonic acid were associated with higher TNF-α (p=0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation.

Authors+Show Affiliations

Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, United States.Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, United States. Electronic address: aus164@psu.edu.Health Diagnostic Laboratory, Inc., Richmond, VA, United States; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States.Department of Mathematics, Lafayette College, Easton, PA 18042, United States.Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, United States.Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, United States.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25091379

Citation

Flock, Michael R., et al. "Effects of Supplemental Long-chain Omega-3 Fatty Acids and Erythrocyte Membrane Fatty Acid Content On Circulating Inflammatory Markers in a Randomized Controlled Trial of Healthy Adults." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 91, no. 4, 2014, pp. 161-8.
Flock MR, Skulas-Ray AC, Harris WS, et al. Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults. Prostaglandins Leukot Essent Fatty Acids. 2014;91(4):161-8.
Flock, M. R., Skulas-Ray, A. C., Harris, W. S., Gaugler, T. L., Fleming, J. A., & Kris-Etherton, P. M. (2014). Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 91(4), 161-8. https://doi.org/10.1016/j.plefa.2014.07.006
Flock MR, et al. Effects of Supplemental Long-chain Omega-3 Fatty Acids and Erythrocyte Membrane Fatty Acid Content On Circulating Inflammatory Markers in a Randomized Controlled Trial of Healthy Adults. Prostaglandins Leukot Essent Fatty Acids. 2014;91(4):161-8. PubMed PMID: 25091379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults. AU - Flock,Michael R, AU - Skulas-Ray,Ann C, AU - Harris,William S, AU - Gaugler,Trent L, AU - Fleming,Jennifer A, AU - Kris-Etherton,Penny M, Y1 - 2014/07/17/ PY - 2014/05/02/received PY - 2014/07/04/revised PY - 2014/07/07/accepted PY - 2014/8/6/entrez PY - 2014/8/6/pubmed PY - 2015/7/16/medline KW - C-reactive protein (CRP) KW - Docosahexaenoic acid (DHA) KW - Docosapentaenoic acid (DPA) KW - Eicosapentaenoic acid (EPA) KW - Inflammation KW - Omega-3 SP - 161 EP - 8 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 91 IS - 4 N2 - The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake (n=116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α (p<0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α (p=0.001); higher quartiles of arachidonic acid were associated with higher TNF-α (p=0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/25091379/Effects_of_supplemental_long_chain_omega_3_fatty_acids_and_erythrocyte_membrane_fatty_acid_content_on_circulating_inflammatory_markers_in_a_randomized_controlled_trial_of_healthy_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(14)00104-5 DB - PRIME DP - Unbound Medicine ER -