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Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis.
J Neurol Sci. 2014 Oct 15; 345(1-2):198-201.JN

Abstract

BACKGROUND

A GWAS found that the single-nucleotide polymorphism rs11833579 near the NINJ2 gene on chromosome 12p13 was associated with an increased risk of ischemic stroke in Caucasians in 2009. Several studies have been carried out to explore the association between this SNP and ischemic stroke in Asians, but published results were contradictory. In the present study, we performed a meta-analysis to further evaluate this association in the Asian population.

METHODS

All relevant articles were retrieved from the databases of PubMed, EMBASE, Chinese Biomedical Literature Database, CNKI, CQVIP, and WANFANG Database from the establishment date to February 2014. Statistical analyses were performed by using Stata 11. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to assess the strength of the association. Possible publication bias was checked by funnel plots, Begg's test and Egger's test.

RESULTS

Eleven studies were eligible for meta-analysis including 9358 cases and 8936 controls. Overall, there were no significant associations between rs11833579 and ischemic stroke under the allelic (OR=0.963, 95% CI: 0.850-1.092, p=0.559), dominant (OR=0.946, 95% CI: 0.778-1.150, p=0.580), recessive (OR=0.993, 95% CI: 0.914-1.078, p=0.868), and homozygote (OR=0.968, 95% CI: 0.796-1.177, p=0.744) genetic models in the Asian population. Further, we found no evidence of association of rs11833579 with large artery atherosclerosis (LAA) or small-artery occlusion (SAO) stroke in all genetic models. The results of the subgroup analysis for Chinese population and Japanese population were consistent with that of the overall study.

CONCLUSIONS

Our meta-analysis shows that SNP rs11833579 is not related to ischemic stroke in the Asian population.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China. Electronic address: wangling@bjmu.edu.cn.Military Hospital of Henan Province, Zhengzhou, China.Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, China.Military Hospital of Henan Province, Zhengzhou, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25096477

Citation

Wang, Ling, et al. "Association Between 12p13 SNP Rs11833579 and Ischemic Stroke in Asian Population: an Updated Meta-analysis." Journal of the Neurological Sciences, vol. 345, no. 1-2, 2014, pp. 198-201.
Wang L, Zhao C, Xia QX, et al. Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis. J Neurol Sci. 2014;345(1-2):198-201.
Wang, L., Zhao, C., Xia, Q. X., & Qiao, S. J. (2014). Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis. Journal of the Neurological Sciences, 345(1-2), 198-201. https://doi.org/10.1016/j.jns.2014.07.047
Wang L, et al. Association Between 12p13 SNP Rs11833579 and Ischemic Stroke in Asian Population: an Updated Meta-analysis. J Neurol Sci. 2014 Oct 15;345(1-2):198-201. PubMed PMID: 25096477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis. AU - Wang,Ling, AU - Zhao,Chi, AU - Xia,Qing-Xin, AU - Qiao,Si-Jie, Y1 - 2014/07/28/ PY - 2014/04/23/received PY - 2014/07/01/revised PY - 2014/07/21/accepted PY - 2014/8/7/entrez PY - 2014/8/7/pubmed PY - 2015/5/29/medline KW - Chromosome 12p13 KW - Ischemic stroke KW - Meta-analysis KW - NINJ2 gene KW - Single nucleotide polymorphisms KW - rs11833579 SP - 198 EP - 201 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 345 IS - 1-2 N2 - BACKGROUND: A GWAS found that the single-nucleotide polymorphism rs11833579 near the NINJ2 gene on chromosome 12p13 was associated with an increased risk of ischemic stroke in Caucasians in 2009. Several studies have been carried out to explore the association between this SNP and ischemic stroke in Asians, but published results were contradictory. In the present study, we performed a meta-analysis to further evaluate this association in the Asian population. METHODS: All relevant articles were retrieved from the databases of PubMed, EMBASE, Chinese Biomedical Literature Database, CNKI, CQVIP, and WANFANG Database from the establishment date to February 2014. Statistical analyses were performed by using Stata 11. The pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to assess the strength of the association. Possible publication bias was checked by funnel plots, Begg's test and Egger's test. RESULTS: Eleven studies were eligible for meta-analysis including 9358 cases and 8936 controls. Overall, there were no significant associations between rs11833579 and ischemic stroke under the allelic (OR=0.963, 95% CI: 0.850-1.092, p=0.559), dominant (OR=0.946, 95% CI: 0.778-1.150, p=0.580), recessive (OR=0.993, 95% CI: 0.914-1.078, p=0.868), and homozygote (OR=0.968, 95% CI: 0.796-1.177, p=0.744) genetic models in the Asian population. Further, we found no evidence of association of rs11833579 with large artery atherosclerosis (LAA) or small-artery occlusion (SAO) stroke in all genetic models. The results of the subgroup analysis for Chinese population and Japanese population were consistent with that of the overall study. CONCLUSIONS: Our meta-analysis shows that SNP rs11833579 is not related to ischemic stroke in the Asian population. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/25096477/Association_between_12p13_SNP_rs11833579_and_ischemic_stroke_in_Asian_population:_An_updated_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(14)00493-6 DB - PRIME DP - Unbound Medicine ER -