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Prevalence, risk factors, and predictors of nonalcoholic fatty liver disease among schoolchildren: a hospital-based study in Alexandria, Egypt.
Arab J Gastroenterol. 2014 Jun; 15(2):76-81.AJ

Abstract

BACKGROUND AND STUDY AIMS

Nonalcoholic fatty liver disease (NAFLD) is an emerging problem in children and adolescents worldwide. This study was done to investigate the prevalence of NAFLD in children and adolescents as well as to determine the associated risk factors of fatty liver and to explore the ability of some obesity indices to predict and consequently be used as a screening method of fatty liver disease at certain cutoff points in schoolchildren.

PATIENTS AND METHODS

A cross-sectional, nested case-control study was carried out. Cases and controls were randomly selected from outpatient schoolchildren aged 6-18years attending the radiology clinic at Sporting Health Insurance Paediatric Hospital in Alexandria. They were subjected to ultrasonic examination as well as complete anthropometric and laboratory measurements including fasting plasma glucose (FPG) level, fasting insulin, alanine aminotransferase (ALT) level, and lipid profile.

RESULTS

Fatty liver was prevalent in schoolchildren (15.8%) and increased significantly with age (p=0.004). Positive family history of diabetes mellitus (DM), hypertension (HTN), obesity, and liver disease were all statistically significant risk factors for fatty liver. Waist circumference (WC), body mass index (BMI) and its Z-score were significantly sensitive predictors. BMI was considered the best predictor of paediatric NAFLD at a cutoff=22.9. NAFLD was significantly associated with high triglycerides (TGs), low high-density lipoprotein cholesterol (HDL), homoeostatic model assessment (HOMA) percentile, and the number of metabolic syndrome (MS) components.

CONCLUSION

Paediatric NAFLD is a substantial problem in schoolchildren and has a close relationship with obesity, dyslipidaemia, insulin resistance (IR), and consequently MS. BMI and WC can be used as useful predictors and screening tools for NAFLD in schoolchildren.

Authors+Show Affiliations

Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt.Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt.Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt. Electronic address: ingy.elghitany@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25097051

Citation

Alkassabany, Yasmine M., et al. "Prevalence, Risk Factors, and Predictors of Nonalcoholic Fatty Liver Disease Among Schoolchildren: a Hospital-based Study in Alexandria, Egypt." Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology, vol. 15, no. 2, 2014, pp. 76-81.
Alkassabany YM, Farghaly AG, El-Ghitany EM. Prevalence, risk factors, and predictors of nonalcoholic fatty liver disease among schoolchildren: a hospital-based study in Alexandria, Egypt. Arab J Gastroenterol. 2014;15(2):76-81.
Alkassabany, Y. M., Farghaly, A. G., & El-Ghitany, E. M. (2014). Prevalence, risk factors, and predictors of nonalcoholic fatty liver disease among schoolchildren: a hospital-based study in Alexandria, Egypt. Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology, 15(2), 76-81. https://doi.org/10.1016/j.ajg.2014.05.002
Alkassabany YM, Farghaly AG, El-Ghitany EM. Prevalence, Risk Factors, and Predictors of Nonalcoholic Fatty Liver Disease Among Schoolchildren: a Hospital-based Study in Alexandria, Egypt. Arab J Gastroenterol. 2014;15(2):76-81. PubMed PMID: 25097051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence, risk factors, and predictors of nonalcoholic fatty liver disease among schoolchildren: a hospital-based study in Alexandria, Egypt. AU - Alkassabany,Yasmine M, AU - Farghaly,Azza G, AU - El-Ghitany,Engy M, Y1 - 2014/07/10/ PY - 2013/07/10/received PY - 2014/02/03/revised PY - 2014/05/22/accepted PY - 2014/8/7/entrez PY - 2014/8/7/pubmed PY - 2015/4/24/medline KW - Children KW - Fatty liver KW - Metabolic syndrome KW - Obesity KW - Predictor KW - Risk factors SP - 76 EP - 81 JF - Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology JO - Arab J Gastroenterol VL - 15 IS - 2 N2 - BACKGROUND AND STUDY AIMS: Nonalcoholic fatty liver disease (NAFLD) is an emerging problem in children and adolescents worldwide. This study was done to investigate the prevalence of NAFLD in children and adolescents as well as to determine the associated risk factors of fatty liver and to explore the ability of some obesity indices to predict and consequently be used as a screening method of fatty liver disease at certain cutoff points in schoolchildren. PATIENTS AND METHODS: A cross-sectional, nested case-control study was carried out. Cases and controls were randomly selected from outpatient schoolchildren aged 6-18years attending the radiology clinic at Sporting Health Insurance Paediatric Hospital in Alexandria. They were subjected to ultrasonic examination as well as complete anthropometric and laboratory measurements including fasting plasma glucose (FPG) level, fasting insulin, alanine aminotransferase (ALT) level, and lipid profile. RESULTS: Fatty liver was prevalent in schoolchildren (15.8%) and increased significantly with age (p=0.004). Positive family history of diabetes mellitus (DM), hypertension (HTN), obesity, and liver disease were all statistically significant risk factors for fatty liver. Waist circumference (WC), body mass index (BMI) and its Z-score were significantly sensitive predictors. BMI was considered the best predictor of paediatric NAFLD at a cutoff=22.9. NAFLD was significantly associated with high triglycerides (TGs), low high-density lipoprotein cholesterol (HDL), homoeostatic model assessment (HOMA) percentile, and the number of metabolic syndrome (MS) components. CONCLUSION: Paediatric NAFLD is a substantial problem in schoolchildren and has a close relationship with obesity, dyslipidaemia, insulin resistance (IR), and consequently MS. BMI and WC can be used as useful predictors and screening tools for NAFLD in schoolchildren. SN - 2090-2387 UR - https://www.unboundmedicine.com/medline/citation/25097051/Prevalence_risk_factors_and_predictors_of_nonalcoholic_fatty_liver_disease_among_schoolchildren:_a_hospital_based_study_in_Alexandria_Egypt_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1687-1979(14)00045-8 DB - PRIME DP - Unbound Medicine ER -