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Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase.
Food Funct. 2014 Oct; 5(10):2420-9.FF

Abstract

It is well known that tea has a variety of beneficial impacts on human health, including anti-obesity effects. It is well documented that green tea and its constituent catechins suppress obesity, but the effects of other types of tea on obesity and the potential mechanisms involved are not yet fully understood. In this study, we investigated the suppression of adiposity by oolong, black and pu-erh tea and characterized the underlying molecular mechanism in vivo. We found that the consumption of oolong, black or pu-erh tea for a period of one week significantly decreased visceral fat without affecting body weight in male ICR mice. On a mechanistic level, the consumption of tea enhanced the phosphorylation of AMP-activated protein kinase (AMPK) in white adipose tissue (WAT). This was accompanied by the induction of WAT protein levels of uncoupling protein 1 and insulin-like growth factor binding protein 1. Our results indicate that oolong, black and pu-erh tea, and in particular, black tea, suppresses adiposity via phosphorylation of the key metabolic regulator AMPK and increases browning of WAT.

Authors+Show Affiliations

Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Nada-ku, Kobe 657-8501, Japan. ashida@kobe-u.ac.jp.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25098399

Citation

Yamashita, Yoko, et al. "Oolong, Black and Pu-erh Tea Suppresses Adiposity in Mice Via Activation of AMP-activated Protein Kinase." Food & Function, vol. 5, no. 10, 2014, pp. 2420-9.
Yamashita Y, Wang L, Wang L, et al. Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase. Food Funct. 2014;5(10):2420-9.
Yamashita, Y., Wang, L., Wang, L., Tanaka, Y., Zhang, T., & Ashida, H. (2014). Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase. Food & Function, 5(10), 2420-9. https://doi.org/10.1039/c4fo00095a
Yamashita Y, et al. Oolong, Black and Pu-erh Tea Suppresses Adiposity in Mice Via Activation of AMP-activated Protein Kinase. Food Funct. 2014;5(10):2420-9. PubMed PMID: 25098399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase. AU - Yamashita,Yoko, AU - Wang,Liuqing, AU - Wang,Lihua, AU - Tanaka,Yuki, AU - Zhang,Tianshun, AU - Ashida,Hitoshi, Y1 - 2014/08/07/ PY - 2014/8/8/entrez PY - 2014/8/8/pubmed PY - 2015/6/3/medline SP - 2420 EP - 9 JF - Food & function JO - Food Funct VL - 5 IS - 10 N2 - It is well known that tea has a variety of beneficial impacts on human health, including anti-obesity effects. It is well documented that green tea and its constituent catechins suppress obesity, but the effects of other types of tea on obesity and the potential mechanisms involved are not yet fully understood. In this study, we investigated the suppression of adiposity by oolong, black and pu-erh tea and characterized the underlying molecular mechanism in vivo. We found that the consumption of oolong, black or pu-erh tea for a period of one week significantly decreased visceral fat without affecting body weight in male ICR mice. On a mechanistic level, the consumption of tea enhanced the phosphorylation of AMP-activated protein kinase (AMPK) in white adipose tissue (WAT). This was accompanied by the induction of WAT protein levels of uncoupling protein 1 and insulin-like growth factor binding protein 1. Our results indicate that oolong, black and pu-erh tea, and in particular, black tea, suppresses adiposity via phosphorylation of the key metabolic regulator AMPK and increases browning of WAT. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/25098399/Oolong_black_and_pu_erh_tea_suppresses_adiposity_in_mice_via_activation_of_AMP_activated_protein_kinase_ L2 - https://doi.org/10.1039/c4fo00095a DB - PRIME DP - Unbound Medicine ER -