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Numerical simulation of red blood cell behavior in a stenosed arteriole using the immersed boundary-lattice Boltzmann method.
Int J Numer Method Biomed Eng 2012; 28(2):239-56IJ

Abstract

Because of their deformability and tendency to form aggregates, red blood cells (RBCs) immensely affect the hydrodynamic properties of blood flow in microcirculation. In this paper, RBCs' two-dimensional deformation and motion in Poiseuille flow and in a stenosed arteriole is numerically investigated by the immersed boundary-lattice Boltzmann method. The RBCs are modeled as suspended capsules of fluid in plasma flow. A neo-Hookean elastic model with bending resistance is utilized for the RBC membrane. Also, the suspending plasma is modeled as an incompressible Newtonian fluid. To take the effects of aggregation and dissociation of RBCs into account, intercellular interaction is modeled by the Morse potential. The effects of essential parameters namely, mechanical resistance of the RBC membrane, plasma viscous forces, and cell membrane adhesion strength on RBC behavior are presented. Motions and deformations of RBCs in a stenosis and the effects of the stenosed zone on the behavior of cell aggregates were also simulated and analyzed in this study.

Authors+Show Affiliations

Biological Fluid Mechanics Research Laboratory, Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Haafez Avenue, Tehran, 15914, Iran.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25099328

Citation

Vahidkhah, Koohyar, and Nasser Fatouraee. "Numerical Simulation of Red Blood Cell Behavior in a Stenosed Arteriole Using the Immersed Boundary-lattice Boltzmann Method." International Journal for Numerical Methods in Biomedical Engineering, vol. 28, no. 2, 2012, pp. 239-56.
Vahidkhah K, Fatouraee N. Numerical simulation of red blood cell behavior in a stenosed arteriole using the immersed boundary-lattice Boltzmann method. Int J Numer Method Biomed Eng. 2012;28(2):239-56.
Vahidkhah, K., & Fatouraee, N. (2012). Numerical simulation of red blood cell behavior in a stenosed arteriole using the immersed boundary-lattice Boltzmann method. International Journal for Numerical Methods in Biomedical Engineering, 28(2), pp. 239-56. doi:10.1002/cnm.1463.
Vahidkhah K, Fatouraee N. Numerical Simulation of Red Blood Cell Behavior in a Stenosed Arteriole Using the Immersed Boundary-lattice Boltzmann Method. Int J Numer Method Biomed Eng. 2012;28(2):239-56. PubMed PMID: 25099328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Numerical simulation of red blood cell behavior in a stenosed arteriole using the immersed boundary-lattice Boltzmann method. AU - Vahidkhah,Koohyar, AU - Fatouraee,Nasser, Y1 - 2011/08/23/ PY - 2010/12/20/received PY - 2011/05/13/revised PY - 2011/06/16/accepted PY - 2014/8/8/entrez PY - 2012/2/1/pubmed PY - 2015/3/10/medline KW - IB-LBM KW - intercellular interaction KW - microcirculation KW - neo-Hookean elastic KW - red blood cell SP - 239 EP - 56 JF - International journal for numerical methods in biomedical engineering JO - Int J Numer Method Biomed Eng VL - 28 IS - 2 N2 - Because of their deformability and tendency to form aggregates, red blood cells (RBCs) immensely affect the hydrodynamic properties of blood flow in microcirculation. In this paper, RBCs' two-dimensional deformation and motion in Poiseuille flow and in a stenosed arteriole is numerically investigated by the immersed boundary-lattice Boltzmann method. The RBCs are modeled as suspended capsules of fluid in plasma flow. A neo-Hookean elastic model with bending resistance is utilized for the RBC membrane. Also, the suspending plasma is modeled as an incompressible Newtonian fluid. To take the effects of aggregation and dissociation of RBCs into account, intercellular interaction is modeled by the Morse potential. The effects of essential parameters namely, mechanical resistance of the RBC membrane, plasma viscous forces, and cell membrane adhesion strength on RBC behavior are presented. Motions and deformations of RBCs in a stenosis and the effects of the stenosed zone on the behavior of cell aggregates were also simulated and analyzed in this study. SN - 2040-7947 UR - https://www.unboundmedicine.com/medline/citation/25099328/Numerical_simulation_of_red_blood_cell_behavior_in_a_stenosed_arteriole_using_the_immersed_boundary_lattice_Boltzmann_method_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=2040-7939&date=2012&volume=28&issue=2&spage=239 DB - PRIME DP - Unbound Medicine ER -