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Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials.
Hepatobiliary Pancreat Dis Int. 2014 Aug; 13(4):354-60.HP

Abstract

BACKGROUND

Liver cirrhotic patients with hepatic encephalopathy have poor prognosis. Probiotics alter the intestinal microbiota and reduce the production of ammonia. We conducted a meta-analysis about the role of probiotics on liver cirrhotic patients with hepatic encephalopathy.

DATA SOURCES

We collected the relevant literatures up to February 21, 2014 from databases of PubMed, EMBASE and the Cochrane Central Register of Controlled Trials. A statistical analysis was conducted by RevMan 5.2 and STATA 12.0 software.

RESULTS

Six randomized controlled trials involving 496 liver cirrhotic patients were included. The results showed that probiotic therapy significantly reduced the development of overt hepatic encephalopathy (OR [95% CI]: 0.42 [0.26, 0.70], P=0.0007). However, probiotics did not affect mortality, levels of serum ammonia and constipation (mortality: OR [95% CI]: 0.73 [0.38, 1.41], P=0.35; serum ammonia: WMD [95% CI]: -3.67 [-15.71, 8.37], P=0.55; constipation: OR [95% CI]: 0.67 [0.29, 1.56], P=0.35).

CONCLUSION

Probiotics decrease overt hepatic encephalopathy in patients with liver cirrhosis.

Authors+Show Affiliations

Department of Surgery, Zhejiang University Hospital, Zhejiang University, Hangzhou 310027, China. zrb94276@zju.edu.cn.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25100119

Citation

Xu, Jun, et al. "Effects of Probiotic Therapy On Hepatic Encephalopathy in Patients With Liver Cirrhosis: an Updated Meta-analysis of Six Randomized Controlled Trials." Hepatobiliary & Pancreatic Diseases International : HBPD INT, vol. 13, no. 4, 2014, pp. 354-60.
Xu J, Ma R, Chen LF, et al. Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials. Hepatobiliary Pancreat Dis Int. 2014;13(4):354-60.
Xu, J., Ma, R., Chen, L. F., Zhao, L. J., Chen, K., & Zhang, R. B. (2014). Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials. Hepatobiliary & Pancreatic Diseases International : HBPD INT, 13(4), 354-60.
Xu J, et al. Effects of Probiotic Therapy On Hepatic Encephalopathy in Patients With Liver Cirrhosis: an Updated Meta-analysis of Six Randomized Controlled Trials. Hepatobiliary Pancreat Dis Int. 2014;13(4):354-60. PubMed PMID: 25100119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of probiotic therapy on hepatic encephalopathy in patients with liver cirrhosis: an updated meta-analysis of six randomized controlled trials. AU - Xu,Jun, AU - Ma,Rui, AU - Chen,Li-Feng, AU - Zhao,Li-Jun, AU - Chen,Kan, AU - Zhang,Ren-Bing, PY - 2014/8/8/entrez PY - 2014/8/8/pubmed PY - 2015/4/24/medline SP - 354 EP - 60 JF - Hepatobiliary & pancreatic diseases international : HBPD INT JO - Hepatobiliary Pancreat Dis Int VL - 13 IS - 4 N2 - BACKGROUND: Liver cirrhotic patients with hepatic encephalopathy have poor prognosis. Probiotics alter the intestinal microbiota and reduce the production of ammonia. We conducted a meta-analysis about the role of probiotics on liver cirrhotic patients with hepatic encephalopathy. DATA SOURCES: We collected the relevant literatures up to February 21, 2014 from databases of PubMed, EMBASE and the Cochrane Central Register of Controlled Trials. A statistical analysis was conducted by RevMan 5.2 and STATA 12.0 software. RESULTS: Six randomized controlled trials involving 496 liver cirrhotic patients were included. The results showed that probiotic therapy significantly reduced the development of overt hepatic encephalopathy (OR [95% CI]: 0.42 [0.26, 0.70], P=0.0007). However, probiotics did not affect mortality, levels of serum ammonia and constipation (mortality: OR [95% CI]: 0.73 [0.38, 1.41], P=0.35; serum ammonia: WMD [95% CI]: -3.67 [-15.71, 8.37], P=0.55; constipation: OR [95% CI]: 0.67 [0.29, 1.56], P=0.35). CONCLUSION: Probiotics decrease overt hepatic encephalopathy in patients with liver cirrhosis. SN - 1499-3872 UR - https://www.unboundmedicine.com/medline/citation/25100119/Effects_of_probiotic_therapy_on_hepatic_encephalopathy_in_patients_with_liver_cirrhosis:_an_updated_meta_analysis_of_six_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1499-3872(14)60280-0 DB - PRIME DP - Unbound Medicine ER -